the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Nov 24, 2026134dpatentJanumet XR(metformin hydrochloride + sitagliptin phosphate)Merck Sharp & Dohme LLC
- Nov 24, 2026134dNPPOpzeluraruxolitinib phosphate$INCYINCYTE CORP
- Nov 24, 2026134dpatentSITAGLIPTIN PHOSPHATESITAGLIPTIN PHOSPHATEMerck Sharp & Dohme LLC
- Nov 26, 2026136dpatentLURASIDONE HYDROCHLORIDELURASIDONE HYDROCHLORIDESumitomo Pharma America Inc
- Nov 28, 2026138dpatentZtalmyganaxoloneMarinus Pharmaceuticals Inc
- Nov 28, 2026138dpatentRopivacaine Hydrochlorideropivacaine [INN]$PRFXPRF Technologies Ltd.
- Nov 29, 2026139dpatentNasonex 24 HR Allergymometasone furoateL. Perrigo Company
- Dec 1, 2026141dpatentZunveylbenzgalantamineAlphaCognition Inc
- Dec 2, 2026142dpatentCLEOCINCLINDAMYCIN PHOSPHATE$PFEPFIZER INC
- Dec 4, 2026144dpatentAdempasriociguatBayer HealthCare Pharmaceuticals Inc
- Dec 5, 2026145dpatentArikayceamikacin sulfate$INSMINSMED Inc
- Dec 5, 2026145dpatentRasagiline Mesylaterasagiline mesylateCarnegie Pharmaceuticals LLC
- Dec 7, 2026147dpatentPANTOPRAZOLE SODIUMPANTOPRAZOLE SODIUMKnack Pharmaceuticals Inc
- Dec 8, 2026148dpatentLarotidamoxicillinNeoPharma Inc
- Dec 8, 2026148dGAINCresembaisavuconazonium sulfateAstellas Pharma US Inc
- Dec 12, 2026152dpatentEpinephrineepinephrineInternational Medication Systems Ltd
- Dec 12, 2026152dODE-280Vyondys 53golodirsen$SRPTSarepta Therapeutics, Inc.
- Dec 12, 2026152dpatentNarcannaloxone hydrochlorideEmergent Devices Inc
- Dec 12, 2026152dpatentKoselugoselumetinib sulfateAstraZeneca Pharmaceuticals LP
- Dec 13, 2026153dNPTRAVOPROSTTRAVOPROSTSandoz Inc
- Dec 13, 2026153dNPIwilfineflornithine hydrochlorideUS WorldMeds LLC
- Dec 14, 2026154dpatentSigniforpasireotideRecordati Corp
- Dec 15, 2026155dPEDTriumeq(abacavir sulfate + dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Dec 19, 2026159dpatentLatissebimatoprost$ABBVAbbVie Inc.
- Dec 19, 2026159dpatentVyndamaxtafamidis$PFEPFIZER INC
- Dec 20, 2026160dPEDSynjardy XR(empagliflozin + metformin hydrochloride)Boehringer Ingelheim Corp
- Dec 20, 2026160dPEDLinagliptin + Metformin Hydrochloride(linagliptin + metformin hydrochloride)MSN Pharmaceuticals Inc
- Dec 20, 2026160dPEDLINAGLIPTINLINAGLIPTINBoehringer Ingelheim Corp
- Dec 20, 2026160dpatentVykat XRdiazoxide choline$SLNOSOLENO THERAPEUTICS INC
- Dec 22, 2026162dI-985Leqvioinclisiran$NVSNOVARTIS AG
- Dec 22, 2026162dpatentIclusigponatinib hydrochloride$TAKTAKEDA PHARMACEUTICAL CO LTD
- Dec 26, 2026166dpatentSymtuza(cobicistat + darunavir + emtricitabine + tenofovir alafenamide)$JNJJOHNSON & JOHNSON
- Dec 26, 2026166dpatentPrezcobix(cobicistat + darunavir)$JNJJOHNSON & JOHNSON
- Dec 26, 2026166dpatentPrezistadarunavirJanssen Therapeutics
- Dec 27, 2026167dODE-283LynparzaolaparibAstraZeneca Pharmaceuticals LP
- Dec 28, 2026168dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Dec 28, 2026168dpatentImbruvicaibrutinib$ABBVAbbVie Inc.
- Dec 30, 2026170dNCE*Recorlevlevoketoconazole$XERSXeris Biopharma Holdings, Inc.
- Jan 1, 2027172dpatentVibativtelavancin hydrochloride$CPIXCUMBERLAND PHARMACEUTICALS INC
- Jan 3, 2027174dPEDNucynta ERtapentadol hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Jan 5, 2027176dpatentZalvisosufentanil citrate$TLPHTALPHERA, INC.
- Jan 6, 2027177dpatentCamptosaririnotecan hydrochloride$PFEPFIZER INC
- Jan 6, 2027177dpatentJatenzotestosterone undecanoate$LPCNLipocine Inc.
- Jan 8, 2027179dM-303METHYLENE BLUEMETHYLENE BLUENexus Pharmaceuticals Inc
- Jan 8, 2027179dpatentHalaveneribulin mesylateEisai Co Ltd
- Jan 8, 2027179dpatentInjectaferferric carboxymaltoseAmerican Regent Inc
- Jan 9, 2027180dODE-356AyvakitavapritinibBlueprint Medicines Corp
- Jan 10, 2027181dNPPDIAZEPAMDIAZEPAMMylan Institutional Inc
- Jan 12, 2027183dpatentWinleviclascoteroneSun Pharmaceutical Industries Ltd
- Jan 14, 2027185dNCECibinqoabrocitinib$PFEPFIZER INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)