the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Mar 15, 2027135dpatentMETADATE ERMETHYLPHENIDATE HYDROCHLORIDELannett Co Inc
- Mar 15, 2027135dpatentTUZISTRA XRCHLORPHENIRAMINE POLISTIREX$TRAWTraws Pharma, Inc.
- Mar 15, 2027135dpatentDyanavel XRamfetamine [INN]Tris Pharma Inc
- Mar 15, 2027135dNPEdurant PEDrilpivirine hydrochloride$JNJJOHNSON & JOHNSON
- Mar 16, 2027136dpatentVanflytaquizartinib dihydrochlorideDaiichi Sankyo Co Ltd
- Mar 19, 2027139dpatentAlcaftadinealcaftadineFosun Pharma USA Inc
- Mar 19, 2027139dpatentLenvimalenvatinib mesylateEisai Co Ltd
- Mar 19, 2027139dODE*Sovaldisofosbuvir$GILDGILEAD SCIENCES, INC.
- Mar 20, 2027140dpatentSpravatoesketamine hydrochlorideJohnson & Johnson Innovative Medicine
- Mar 22, 2027142dI-943Nexlizet(bempedoic acid + ezetimibe)$ESPREsperion Therapeutics, Inc.
- Mar 22, 2027142dpatentDICLOFENAC SODIUMDICLOFENAC SODIUMAltaire Pharmaceuticals Inc
- Mar 22, 2027142dI-943Nexletolbempedoic acid$ESPREsperion Therapeutics, Inc.
- Mar 23, 2027143dpatentACYCLOVIRACYCLOVIRYiling Pharmaceutical Ltd
- Mar 23, 2027143dI-965Pluvictolutetium Lu 177 vipivotide tetraxetan$NVSNOVARTIS AG
- Mar 27, 2027147dpatentTRAZODONE HYDROCHLORIDETRAZODONE HYDROCHLORIDEAurolife Pharma LLC
- Mar 27, 2027147dpatentErleadaapalutamide [INN]$JNJJOHNSON & JOHNSON
- Apr 2, 2027153dI-939Fanaptiloperidone$VNDAVanda Pharmaceuticals Inc.
- Apr 4, 2027155dNPXromihydroxyureaNova Laboratories Ltd
- Apr 4, 2027155dpatentVarubirolapitant hydrochlorideTerSera Therapeutics LLC
- Apr 5, 2027156dNPPDovato(dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Apr 5, 2027156dpatentCotelliccobimetinib fumarateGenentech Inc
- Apr 6, 2027157dpatentEdluarzolpidem tartrateMylan Specialty LP
- Apr 7, 2027158dpatentSyfovrepegcetacoplan$APLSApellis Pharmaceuticals, Inc.
- Apr 7, 2027158dM-200Quviviqdaridorexant hydrochlorideIdorsia Pharmaceutical Ltd
- Apr 10, 2027161dpatentSpiriva Handihalertiotropium bromideBoehringer Ingelheim Corp
- Apr 13, 2027164dpatentOXCARBAZEPINEOXCARBAZEPINEAucta Pharmaceuticals Inc
- Apr 15, 2027166dpatentTrijardy XR(empagliflozin + linagliptin + metformin hydrochloride)Boehringer Ingelheim Corp
- Apr 15, 2027166dpatentGlyxambi(empagliflozin + linagliptin)Boehringer Ingelheim Corp
- Apr 15, 2027166dNPJelmytomitomycin$URGNUroGen Pharma Ltd.
- Apr 17, 2027168dpatentClonidineclonidineDr. Reddy's Laboratories Ltd
- Apr 17, 2027168dODE-292Pemazyrepemigatinib$INCYINCYTE CORP
- Apr 17, 2027168dODE-309TukysatucatinibSeagen Inc
- Apr 18, 2027169dpatentNICARDIPINE HYDROCHLORIDENICARDIPINE HYDROCHLORIDE$AMRXAmneal Pharmaceuticals, Inc.
- Apr 18, 2027169dI-947AlecensaalectinibF. Hoffmann-La Roche Ltd
- Apr 18, 2027169dpatentSavaysaedoxaban tosylateDaiichi Sankyo Co Ltd
- Apr 21, 2027172dpatentNoxiventnitric oxide$LINLINDE PLC
- Apr 23, 2027174dNPPLutatheralutetium Lu 177 dotatateAdvanced Accelerator Applications SA
- Apr 25, 2027176dpatentFOAMING HAND WASHCHLORHEXIDINE GLUCONATEXTTRIUM
- Apr 26, 2027177dGAINVivjoaoteseconazoleMycovia Pharmaceuticals Inc
- Apr 26, 2027177dpatentSimvastatinsimvastatinYiling Pharmaceutical Ltd
- Apr 26, 2027177dNPRinvoq LQupadacitinib$ABBVAbbVie Inc.
- Apr 26, 2027177dI-946Rinvoqupadacitinib tartrate$ABBVAbbVie Inc.
- Apr 27, 2027178dpatentLENALIDOMIDELENALIDOMIDEBristol-Myers Squibb Co
- Apr 28, 2027179dNCECamzyosmavacamtenBristol-Myers Squibb Co
- Apr 29, 2027180dODE-295Zejulaniraparib$JNJJOHNSON & JOHNSON
- May 2, 2027183dpatentTriamcinolone Acetonidetriamcinolone acetonideRising Pharma Holdings Inc
- May 3, 2027184dGAINVoquezna Triple Pakamoxicillin + clarithromycin + vonoprazan [INN]$PHATPhathom Pharmaceuticals, Inc.
- May 3, 2027184dGAINVoquezna Dual Pakamoxicillin + vonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- May 6, 2027187dODE-291Tabrectacapmatinib hydrochloride$NVSNOVARTIS AG
- May 8, 2027189dM-311RetevmoselpercatinibEli Lilly and Co
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)