the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 19, 2027126dI-930Balversaerdafitinib$JNJJOHNSON & JOHNSON
- Jan 19, 2027126dpatentStriverdi Respimatolodaterol hydrochlorideBoehringer Ingelheim Corp
- Jan 20, 2027127dpatentKyproliscarfilzomib$AMGNAMGEN INC
- Jan 20, 2027127dpatentBendaviaelamipretide hydrochlorideStealth BioTherapeutics Inc
- Jan 22, 2027129dpatentActoplus Met(metformin hydrochloride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 23, 2027130dpatentVyxeos(cytarabine hydrochloride + daunorubicin hydrochloride)$JAZZJazz Pharmaceuticals plc
- Jan 23, 2027130dpatentAmitizalubiprostoneMallinckrodt LLC
- Jan 24, 2027131dODE-367DificidfidaxomicinCubist Pharmaceuticals LLC
- Jan 25, 2027132dpatentFentanylfentanylActavis Elizabeth LLC
- Jan 26, 2027133dpatentProcysbicysteamineHorizon Therapeutics USA Inc
- Jan 30, 2027137dpatentDuetact(glimepiride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 31, 2027138dpatentIlevronepafenac$HROWHARROW, INC.
- Feb 1, 2027139dpatentMalathionSuven Life Sciences Ltd
- Feb 2, 2027140dpatentEPOPROSTENOL SODIUMEPOPROSTENOL SODIUMJanssen-Cilag Holdings Inc (Inactive)
- Feb 2, 2027140dpatentREGADENOSONREGADENOSONAPOTEX
- Feb 2, 2027140dpatentRayaldeecalcifediolOPKO Pharmaceuticals LLC
- Feb 7, 2027145dpatentPlan B One-SteplevonorgestrelFoundation Consumer Healthcare LLC
- Feb 9, 2027147dpatentavutometinib potassium$VSTMVerastem, Inc.
- Feb 12, 2027150dpatentRapivabperamivir$BCRXBIOCRYST PHARMACEUTICALS INC
- Feb 13, 2027151dNPAurlumyniloprostBTG International Inc
- Feb 13, 2027151dpatentAbraxanepaclitaxelCelgene Corp
- Feb 16, 2027154dpatentEucrisacrisaborole$PFEPFIZER INC
- Feb 16, 2027154dI-941Tagrissoosimertinib mesylate$AZNASTRAZENECA PLC
- Feb 17, 2027155dNCEPyrukyndmitapivat sulfate$AGIOAGIOS PHARMACEUTICALS, INC.
- Feb 23, 2027161dI-942Biktarvy(bictegravir sodium + emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Feb 24, 2027162dpatentBalsalazide Disodiumbalsalazide disodiumCarnegie Pharmaceuticals LLC
- Feb 28, 2027166dpatentAdvil Allergy Sinus(chlorpheniramine maleate + ibuprofen + pseudoephedrine hydrochloride)$HLNHaleon plc
- Feb 28, 2027166dpatentLinzesslinaclotide$ABBVAbbVie Inc.
- Feb 28, 2027166dNCEVonjopacritinibSobi Inc
- Mar 2, 2027168dpatentAbilify MaintenaaripiprazoleOtsuka America Pharmaceutical Inc
- Mar 4, 2027170dNPClobetasol Propionateclobetasol propionateTeva Pharmaceuticals USA Inc
- Mar 5, 2027171dpatentIbrancepalbociclib$OTLCOncotelic Therapeutics, Inc.
- Mar 6, 2027172dPEDOfevnintedanib esylateBoehringer Ingelheim Corp
- Mar 6, 2027172dODE-286Isturisaosilodrostat phosphateRecordati Rare Diseases Inc
- Mar 7, 2027173dpatentMINOCYCLINE HYDROCHLORIDEMINOCYCLINE HYDROCHLORIDEThe Medicines Co
- Mar 8, 2027174dI-935WegovysemaglutideNovo Nordisk Inc
- Mar 10, 2027176dpatentDuavee(bazedoxifene acetate + conjugated estrogens)$PFEPFIZER INC
- Mar 11, 2027177dpatentOpsynvi(macitentan + tadalafil)Janssen Biotech Inc
- Mar 11, 2027177dpatentMACITENTANMACITENTAN$JNJJOHNSON & JOHNSON
- Mar 11, 2027177dpatentZolinzavorinostat$MRKMerck & Co., Inc.
- Mar 12, 2027178dpatentTeriflunomideteriflunomideSOLA Pharmaceuticals Inc
- Mar 15, 2027181dpatentDYANAVEL XR 20AMPHETAMINE$TRAWTraws Pharma, Inc.
- Mar 15, 2027181dpatentMETADATE ERMETHYLPHENIDATE HYDROCHLORIDELannett Co Inc
- Mar 15, 2027181dpatentTUZISTRA XRCHLORPHENIRAMINE POLISTIREX$TRAWTraws Pharma, Inc.
- Mar 15, 2027181dpatentDyanavel XRamfetamine [INN]Tris Pharma Inc
- Mar 15, 2027181dNPEdurant PEDrilpivirine hydrochloride$JNJJOHNSON & JOHNSON
- Mar 16, 2027182dpatentVanflytaquizartinib dihydrochlorideDaiichi Sankyo Co Ltd
- Mar 19, 2027185dpatentAlcaftadinealcaftadineFosun Pharma USA Inc
- Mar 19, 2027185dODE*Sovaldisofosbuvir$GILDGILEAD SCIENCES, INC.
- Mar 20, 2027186dpatentSpravatoesketamine hydrochlorideJohnson & Johnson Innovative Medicine
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)