the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Oct 30, 2026-1dI-967Mavyret(glecaprevir + pibrentasvir)$ABBVAbbVie Inc.
- Oct 31, 20260dpatentSELEXIPAGSELEXIPAG$JNJJOHNSON & JOHNSON
- Nov 1, 20261dGAINVoqueznavonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- Nov 2, 20262dpatentPREGABALINPREGABALINRK Pharma Inc
- Nov 3, 20263dM-14Kalydecoivacaftor$VERXVertex, Inc.
- Nov 5, 20265dpatentRisperidonerisperidoneSenores Pharmaceuticals Inc
- Nov 8, 20268dpatentOrkambi(ivacaftor + lumacaftor)$VERXVertex, Inc.
- Nov 8, 20268dpatentSacubitril + Valsartan(sacubitril + valsartan)Novugen Pharma (Malaysia) Sdn Bhd
- Nov 8, 20268dpatentSACUBITRIL AND VALSARTANSACUBITRILSomerset Therapeutics LLC
- Nov 8, 20268dI-958ZEPBOUNDTIRZEPATIDE$LLYELI LILLY & Co
- Nov 8, 20268dNPPFarxigadapagliflozin propanediol$AZNASTRAZENECA PLC
- Nov 9, 20269dpatentGilotrifafatinib dimaleateBoehringer Ingelheim Corp
- Nov 9, 20269dpatentTarpeyobudesonideCalliditas Therapeutics AB
- Nov 9, 20269dI-929ExparelbupivacaineAllay Therapeutics Inc
- Nov 10, 202610dM-14BREXPIPRAZOLEBREXPIPRAZOLE$AMRXAmneal Pharmaceuticals, Inc.
- Nov 10, 202610dpatentHorizantgabapentin enacarbilAzurity Pharmaceuticals Inc
- Nov 11, 202611dpatentIzervayavacincaptad pegol sodiumAstellas Pharma US Inc
- Nov 12, 202612dpatentEmblaveo(avibactam sodium + aztreonam)$ABBVAbbVie Inc.
- Nov 12, 202612dpatentAvycaz(avibactam sodium + ceftazidime)$ABBVAbbVie Inc.
- Nov 13, 202613dPEDBreo Ellipta(fluticasone furoate + vilanterol trifenatate)GlaxoSmithKline LLC
- Nov 13, 202613dpatentSofdrasofpironium bromideBotanix Pharmaceuticals Ltd
- Nov 14, 202614dI-936Brukinsazanubrutinib$ONCBeOne Medicines Ltd.
- Nov 15, 202615dpatentHernexeoszongertinibBoehringer Ingelheim Corp
- Nov 17, 202617dI-926XtandienzalutamideAlessa Therapeutics Inc
- Nov 19, 202619dNCEVoxzogovosoritide$BMRNBIOMARIN PHARMACEUTICAL INC
- Nov 20, 202620dODE-273Givlaarigivosiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Nov 21, 202621dI-960CALQUENCEACALABRUTINIB$AZNASTRAZENECA PLC
- Nov 21, 202621dpatentEliquisapixabanBristol-Myers Squibb Co
- Nov 22, 202622dpatentSUMATRIPTAN SUCCINATESUMATRIPTAN SUCCINATEAllergan USA Inc
- Nov 23, 202623dpatentBosutinibbosutinibAlembic Pharmaceuticals Inc
- Nov 23, 202623dNCELivtencitymaribavirTakeda Pharmaceuticals USA Inc
- Nov 24, 202624dpatentSteglujan(ertugliflozin + sitagliptin phosphate)Merck Sharp & Dohme (IA) LLC
- Nov 24, 202624dpatentJanumet XR(metformin hydrochloride + sitagliptin phosphate)Merck Sharp & Dohme LLC
- Nov 24, 202624dNPPOpzeluraruxolitinib phosphate$INCYINCYTE CORP
- Nov 24, 202624dpatentSITAGLIPTIN PHOSPHATESITAGLIPTIN PHOSPHATEMerck Sharp & Dohme LLC
- Nov 24, 202624dpatentMetformin Hydrochloridemetformin hydrochlorideIntellipharmaceutics Ltd
- Nov 26, 202626dpatentLURASIDONE HYDROCHLORIDELURASIDONE HYDROCHLORIDESumitomo Pharma America Inc
- Nov 28, 202628dpatentZtalmyganaxoloneMarinus Pharmaceuticals Inc
- Nov 28, 202628dpatentRopivacaine Hydrochlorideropivacaine [INN]$PRFXPRF Technologies Ltd.
- Nov 29, 202629dpatentNasonex 24 HR Allergymometasone furoateL. Perrigo Company
- Dec 1, 202631dpatentSirturobedaquiline fumarateJanssen Therapeutics
- Dec 1, 202631dpatentZunveylbenzgalantamineAlphaCognition Inc
- Dec 2, 202632dpatentCLEOCINCLINDAMYCIN PHOSPHATE$PFEPFIZER INC
- Dec 4, 202634dpatentAdempasriociguatBayer HealthCare Pharmaceuticals Inc
- Dec 5, 202635dM-307DASATINIBDASATINIBXspray Pharma AB
- Dec 5, 202635dpatentArikayceamikacin sulfate$INSMINSMED Inc
- Dec 5, 202635dpatentRasagiline Mesylaterasagiline mesylateCarnegie Pharmaceuticals LLC
- Dec 7, 202637dpatentPANTOPRAZOLE SODIUMPANTOPRAZOLE SODIUMKnack Pharmaceuticals Inc
- Dec 8, 202638dpatentLarotidamoxicillinNeoPharma Inc
- Dec 8, 202638dGAINCresembaisavuconazonium sulfateAstellas Pharma US Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)