the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jul 6, 2026-1dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Jul 6, 2026-1dpatentTRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR$VERXVertex, Inc.
- Jul 6, 2026-1dpatentKalydecoivacaftor$VERXVertex, Inc.
- Jul 8, 20261dpatentOfevnintedanib esylateBoehringer Ingelheim Corp
- Jul 9, 20262dI-970KerendiafinerenoneBayer AG
- Jul 11, 20264dpatentRocklatan(latanoprost + netarsudil mesylate)$ALCALCON INC
- Jul 11, 20264dpatentRhopressanetarsudil mesylate$ALCALCON INC
- Jul 12, 20265dpatentBelrapzobendamustine hydrochlorideEagle Pharmaceuticals Inc
- Jul 13, 20266dpatentGilotrifafatinib dimaleateBoehringer Ingelheim Corp
- Jul 13, 20266dRTOOpillnorgestrelHRA Pharma LLC
- Jul 13, 20266dM-301Vekluryremdesivir$GILDGILEAD SCIENCES, INC.
- Jul 14, 20267dCGTInveltysloteprednol etabonate$ALCALCON INC
- Jul 16, 20269dNCERezurockbelumosudil mesylateKadmon Pharmaceuticals LLC
- Jul 16, 20269dNCEFexinidazolefexinidazoleSanofi-Aventis US LLC
- Jul 17, 202610dpatentDexlansoprazoledexlansoprazoleTWi Pharmaceuticals USA Inc
- Jul 18, 202611dpatentNILOTINIB HYDROCHLORIDENILOTINIB HYDROCHLORIDEHetero Labs Ltd
- Jul 18, 202611dpatentPepcidfamotidine$KVUEKenvue Inc.
- Jul 19, 202612dpatentJelmytomitomycin$URGNUroGen Pharma Ltd.
- Jul 19, 202612dpatentSpiriva Handihalertiotropium bromideBoehringer Ingelheim Corp
- Jul 19, 202612dM-299ApremilastapremilastAnnora Pharma Pvt Ltd
- Jul 20, 202613dpatentKyproliscarfilzomib$AMGNAMGEN INC
- Jul 20, 202613dNCEBylvayodevixibatIpsen SA
- Jul 20, 202613dpatentTemsirolimustemsirolimusAccord Healthcare Inc
- Jul 21, 202614dD-190WegovysemaglutideNovo Nordisk Inc
- Jul 24, 202617dpatentLidocaine Hydrochloridelidocaine hydrochlorideInternational Medication Systems Ltd
- Jul 26, 202619dCGTIOHEXOLIOHEXOL$AMRXAmneal Pharmaceuticals, Inc.
- Jul 26, 202619dpatentOngentysopicapone [INN]$AMRXAmneal Pharmaceuticals, Inc.
- Jul 27, 202620dM-300Kazano(alogliptin benzoate + metformin hydrochloride)Takeda Pharmaceuticals USA Inc
- Jul 27, 202620dM-300Alogliptin Benzoate Perrigoalogliptin benzoatePerrigo New York Inc
- Jul 27, 202620dCGTMycapssaoctreotide acetateChiasma Inc
- Jul 27, 202620dpatentSugammadex Sodiumsugammadex sodiumB. Braun Medical Inc
- Jul 28, 202621dpatentAbilify MaintenaaripiprazoleOtsuka America Pharmaceutical Inc
- Jul 30, 202623dpatentOrenitramtreprostinil diolamine$UTHRUNITED THERAPEUTICS Corp
- Jul 31, 202624dpatentSUMATRIPTAN SUCCINATESUMATRIPTAN SUCCINATEAllergan USA Inc
- Jul 31, 202624dpatentSublocadebuprenorphine [INN]$INDVIndivior Pharmaceuticals, Inc.
- Jul 31, 202624dpatentMetformin Hydrochloridemetformin hydrochlorideIntellipharmaceutics Ltd
- Aug 2, 202626dpatentBalsalazide Disodiumbalsalazide disodiumCarnegie Pharmaceuticals LLC
- Aug 2, 202626dD-189PrevymisletermovirMerck Sharp & Dohme Corp (Inactive)
- Aug 2, 202626dODE*Turaliopexidartinib hydrochlorideDaiichi Sankyo Co Ltd
- Aug 2, 202626dpatentLivdelziseladelpar lysineCymaBay Therapeutics Inc
- Aug 2, 202626dpatentZelborafvemurafenibF. Hoffmann-La Roche Ltd
- Aug 4, 202628dpatentBrisdelleparoxetine mesylateLegacy Pharma Solutions
- Aug 6, 202630dpatentBaxdeladelafloxacin meglumineMelinta Therapeutics LLC
- Aug 9, 202633dM-306Sirturobedaquiline fumarateJanssen Therapeutics
- Aug 10, 202634dpatentBeleodaqbelinostatAcrotech Biopharma Inc
- Aug 11, 202635dI-980Akeega(abiraterone acetate + niraparib)$JNJJOHNSON & JOHNSON
- Aug 11, 202635dpatentOsphenaospemifeneDuchesnay USA Inc
- Aug 13, 202637dpatentNuedexta(dextromethorphan [INN] + quinidine sulfate)Otsuka America Pharmaceutical Inc
- Aug 13, 202637dI-931Weliregbelzutifan$MRKMerck & Co., Inc.
- Aug 13, 202637dpatentAbraxanepaclitaxelCelgene Corp
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)