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  1. pharmadog
  2. ›drugs
  3. ›Spravato
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save

esketamine hydrochloride

Marketedupdated 3mo ago
by Johnson & Johnson Innovative Medicine
Approved
annual revenue · 2024–2024peak $1.0B
2024: $1.0B2024$1.0B
community read0 votes

🐶 often sniffed alongside

top 5
  • tagApproval68 co-mentions · 17 sources
  • drugesketamine35 co-mentions · 18 sources
  • drugSRX-2535 co-mentions · 18 sources
  • companyChiral Biotech Pharma Pty Ltd1 co-mentions · 1 sources
  • tagMajor Depression1 co-mentions · 1 sources

indications

investigational
Major Depression

all catalysts(1)

phase 1 initiation · 1
Apr 30, 2026
phase 1 initiation
4mo ago
Chiral Biotech Pharma Pty Ltd — esketamine hydrochloride (Phase I Trial Initiation)
esketamine hydrochloride
→

Trials studying esketamine hydrochloride

  • phase4Positioning of Esketamine Treatment in the Real-world Management of Depressionrecruitingn=162

Patent cliff

source: FDA Orange Book
first barrier falls
Mar 20, 2027
211 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (7)

  • Feb 18, 2040method-of-use (U-3813)US 11883526
  • Sep 10, 2035method-of-use (U-3036)US 10869844
  • Sep 10, 2035method-of-use (U-3257)US 11173134
  • Sep 10, 2035method-of-use (U-3035)US 11311500
  • Mar 14, 2034method-of-use (U-3446)US 11446260
  • Mar 5, 2033method-of-use (U-4112)US 8785500
  • Mar 20, 2027method-of-use (U-4112)US 9592207211d

FDA exclusivities (1)

  • Jan 17, 2028I-959Indication (3y)1.4y

News(9)

  • Psychedelics on the cusp of market breakthrough as clinical, policy support grow
    While there are several FDA-approved psychiatric medicines on the market, many patients still struggle to achieve lasting symptom relief. Psychedelics could help fill this gap.
    biospace · 11d ago
  • Lilly’s $3.8B psychedelics bet won’t open the M&A floodgates
    Eli Lilly’s $3.8 billion play for AtaiBeckley has fueled speculation that Big Pharma is ready to embrace psychedelics. But while the acquisition does validate the drug class, analysts say it is unl…
    biospace · 27d ago
  • Lilly’s AtaiBeckley buy validates space as Big Pharma takes note of psychedelics
    Eli Lilly’s proposed acquisition of AtaiBeckley is “the clearest strategic validation to date” of psychedelics as an emerging pharmaceutical category, according to H.C. Wainwright. The analyst caut…
    biospace · 1mo ago
  • ‘A rising tide scenario’: Why other Big Pharmas could follow Lilly into psychedelics
    After Eli Lilly dived into the psychedelics space with a $2.8 billion upfront acquisition of AtaiBeckley last week, industry experts told Fierce that the deal would give the space added momentum.
    fiercebiotech · 1mo ago
  • Lilly to buy AtaiBeckley for $2.8B, further validating psychedelics
    The latest in a prolific streak of buyouts by Lilly is the strongest sign yet that large pharmaceutical companies may finally be embracing a long-dismissed field of research.
    biopharma_dive · 1mo ago
  • Lilly makes up to $3.8B psychedelics play in AtaiBeckley takeover
    With the AtaiBeckley acquisition, Eli Lilly is jumping into psychedelics, a drug class that Jefferies analysts say could herald the “biggest change” for the field of psychiatry.
    biospace · 1mo ago
  • J&J sees Spravato sales surge as psychedelic competitors loom
    Psychedelics, chiefly Compass Pathways' COMP360, are unlikely to make an immediate dent in the sales of Johnson & Johnson’s depression drug Spravato, H.C. Wainwright’s Patrick Trucchio told BioSpace.
    biospace · 1mo ago
  • J&J dips despite upbeat outlook; AstraZeneca, Spero cut China deals
    J&J’s shares ticked down as oncology sales missed expectations. Elsewhere, AstraZeneca bet $600 million on a lung cancer drug and a pair of biotechs snagged two of the year’s top venture rounds.
    biopharma_dive · 1mo ago
  • Another big premium hike on the horizon
    FDA's crackdown on online ketamine retailers, unprecedented health care premium hikes, and more health news from Morning Rounds
    stat · 1mo ago
brand
Spravato
generic
esketamine hydrochloride
indication
Major Depressive Disorder
phase
marketed
approved
2019-03-05
Data sources
openFDA · ClinicalTrials.gov
last refreshed 8m ago
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