the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Nov 21, 2026134dI-960CALQUENCEACALABRUTINIB$AZNASTRAZENECA PLC
- Nov 21, 2026134dpatentEliquisapixabanBristol-Myers Squibb Co
- Nov 23, 2026136dNCELivtencitymaribavirTakeda Pharmaceuticals USA Inc
- Nov 24, 2026137dpatentSteglujan(ertugliflozin + sitagliptin phosphate)Merck Sharp & Dohme (IA) LLC
- Nov 24, 2026137dpatentJanumet XR(metformin hydrochloride + sitagliptin phosphate)Merck Sharp & Dohme LLC
- Nov 24, 2026137dNPPOpzeluraruxolitinib phosphate$INCYINCYTE CORP
- Nov 24, 2026137dpatentSITAGLIPTIN PHOSPHATESITAGLIPTIN PHOSPHATEMerck Sharp & Dohme LLC
- Nov 26, 2026139dpatentLURASIDONE HYDROCHLORIDELURASIDONE HYDROCHLORIDESumitomo Pharma America Inc
- Nov 28, 2026141dpatentZtalmyganaxoloneMarinus Pharmaceuticals Inc
- Nov 28, 2026141dpatentRopivacaine Hydrochlorideropivacaine [INN]$PRFXPRF Technologies Ltd.
- Nov 29, 2026142dpatentNasonex 24 HR Allergymometasone furoateL. Perrigo Company
- Dec 1, 2026144dpatentZunveylbenzgalantamineAlphaCognition Inc
- Dec 2, 2026145dpatentCLEOCINCLINDAMYCIN PHOSPHATE$PFEPFIZER INC
- Dec 4, 2026147dpatentAdempasriociguatBayer HealthCare Pharmaceuticals Inc
- Dec 5, 2026148dpatentArikayceamikacin sulfate$INSMINSMED Inc
- Dec 5, 2026148dpatentRasagiline Mesylaterasagiline mesylateCarnegie Pharmaceuticals LLC
- Dec 7, 2026150dpatentPANTOPRAZOLE SODIUMPANTOPRAZOLE SODIUMKnack Pharmaceuticals Inc
- Dec 8, 2026151dpatentLarotidamoxicillinNeoPharma Inc
- Dec 8, 2026151dGAINCresembaisavuconazonium sulfateAstellas Pharma US Inc
- Dec 12, 2026155dpatentEpinephrineepinephrineInternational Medication Systems Ltd
- Dec 12, 2026155dODE-280Vyondys 53golodirsen$SRPTSarepta Therapeutics, Inc.
- Dec 12, 2026155dpatentNarcannaloxone hydrochlorideEmergent Devices Inc
- Dec 12, 2026155dpatentKoselugoselumetinib sulfateAstraZeneca Pharmaceuticals LP
- Dec 13, 2026156dNPTRAVOPROSTTRAVOPROSTSandoz Inc
- Dec 13, 2026156dNPIwilfineflornithine hydrochlorideUS WorldMeds LLC
- Dec 14, 2026157dpatentSigniforpasireotideRecordati Corp
- Dec 15, 2026158dPEDTriumeq(abacavir sulfate + dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Dec 19, 2026162dpatentLatissebimatoprost$ABBVAbbVie Inc.
- Dec 19, 2026162dpatentVyndamaxtafamidis$PFEPFIZER INC
- Dec 20, 2026163dPEDSynjardy XR(empagliflozin + metformin hydrochloride)Boehringer Ingelheim Corp
- Dec 20, 2026163dPEDLinagliptin + Metformin Hydrochloride(linagliptin + metformin hydrochloride)MSN Pharmaceuticals Inc
- Dec 20, 2026163dPEDLINAGLIPTINLINAGLIPTINBoehringer Ingelheim Corp
- Dec 20, 2026163dpatentVykat XRdiazoxide choline$SLNOSOLENO THERAPEUTICS INC
- Dec 22, 2026165dI-985Leqvioinclisiran$NVSNOVARTIS AG
- Dec 22, 2026165dpatentIclusigponatinib hydrochloride$TAKTAKEDA PHARMACEUTICAL CO LTD
- Dec 26, 2026169dpatentSymtuza(cobicistat + darunavir + emtricitabine + tenofovir alafenamide)$JNJJOHNSON & JOHNSON
- Dec 26, 2026169dpatentPrezcobix(cobicistat + darunavir)$JNJJOHNSON & JOHNSON
- Dec 26, 2026169dpatentPrezistadarunavirJanssen Therapeutics
- Dec 27, 2026170dODE-283LynparzaolaparibAstraZeneca Pharmaceuticals LP
- Dec 28, 2026171dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Dec 28, 2026171dpatentImbruvicaibrutinib$ABBVAbbVie Inc.
- Dec 30, 2026173dNCE*Recorlevlevoketoconazole$XERSXeris Biopharma Holdings, Inc.
- Jan 1, 2027175dpatentVibativtelavancin hydrochloride$CPIXCUMBERLAND PHARMACEUTICALS INC
- Jan 3, 2027177dPEDNucynta ERtapentadol hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Jan 5, 2027179dpatentZalvisosufentanil citrate$TLPHTALPHERA, INC.
- Jan 6, 2027180dpatentCamptosaririnotecan hydrochloride$PFEPFIZER INC
- Jan 6, 2027180dpatentJatenzotestosterone undecanoate$LPCNLipocine Inc.
- Jan 8, 2027182dM-303METHYLENE BLUEMETHYLENE BLUENexus Pharmaceuticals Inc
- Jan 8, 2027182dpatentHalaveneribulin mesylateEisai Co Ltd
- Jan 8, 2027182dpatentInjectaferferric carboxymaltoseAmerican Regent Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)