the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Nov 21, 2026137dI-960CALQUENCEACALABRUTINIB$AZNASTRAZENECA PLC
- Nov 21, 2026137dpatentEliquisapixabanBristol-Myers Squibb Co
- Nov 23, 2026139dNCELivtencitymaribavirTakeda Pharmaceuticals USA Inc
- Nov 24, 2026140dpatentSteglujan(ertugliflozin + sitagliptin phosphate)Merck Sharp & Dohme (IA) LLC
- Nov 24, 2026140dpatentJanumet XR(metformin hydrochloride + sitagliptin phosphate)Merck Sharp & Dohme LLC
- Nov 24, 2026140dNPPOpzeluraruxolitinib phosphate$INCYINCYTE CORP
- Nov 24, 2026140dpatentSITAGLIPTIN PHOSPHATESITAGLIPTIN PHOSPHATEMerck Sharp & Dohme LLC
- Nov 26, 2026142dpatentLURASIDONE HYDROCHLORIDELURASIDONE HYDROCHLORIDESumitomo Pharma America Inc
- Nov 28, 2026144dpatentZtalmyganaxoloneMarinus Pharmaceuticals Inc
- Nov 28, 2026144dpatentRopivacaine Hydrochlorideropivacaine [INN]$PRFXPRF Technologies Ltd.
- Nov 29, 2026145dpatentNasonex 24 HR Allergymometasone furoateL. Perrigo Company
- Dec 1, 2026147dpatentZunveylbenzgalantamineAlphaCognition Inc
- Dec 2, 2026148dpatentCLEOCINCLINDAMYCIN PHOSPHATE$PFEPFIZER INC
- Dec 4, 2026150dpatentAdempasriociguatBayer HealthCare Pharmaceuticals Inc
- Dec 5, 2026151dpatentArikayceamikacin sulfate$INSMINSMED Inc
- Dec 5, 2026151dpatentRasagiline Mesylaterasagiline mesylateCarnegie Pharmaceuticals LLC
- Dec 7, 2026153dpatentPANTOPRAZOLE SODIUMPANTOPRAZOLE SODIUMKnack Pharmaceuticals Inc
- Dec 8, 2026154dpatentLarotidamoxicillinNeoPharma Inc
- Dec 8, 2026154dGAINCresembaisavuconazonium sulfateAstellas Pharma US Inc
- Dec 12, 2026158dpatentEpinephrineepinephrineInternational Medication Systems Ltd
- Dec 12, 2026158dODE-280Vyondys 53golodirsen$SRPTSarepta Therapeutics, Inc.
- Dec 12, 2026158dpatentNarcannaloxone hydrochlorideEmergent Devices Inc
- Dec 12, 2026158dpatentKoselugoselumetinib sulfateAstraZeneca Pharmaceuticals LP
- Dec 13, 2026159dNPTRAVOPROSTTRAVOPROSTSandoz Inc
- Dec 13, 2026159dNPIwilfineflornithine hydrochlorideUS WorldMeds LLC
- Dec 14, 2026160dpatentSigniforpasireotideRecordati Corp
- Dec 15, 2026161dPEDTriumeq(abacavir sulfate + dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Dec 19, 2026165dpatentLatissebimatoprost$ABBVAbbVie Inc.
- Dec 19, 2026165dpatentVyndamaxtafamidis$PFEPFIZER INC
- Dec 20, 2026166dPEDSynjardy XR(empagliflozin + metformin hydrochloride)Boehringer Ingelheim Corp
- Dec 20, 2026166dPEDLinagliptin + Metformin Hydrochloride(linagliptin + metformin hydrochloride)MSN Pharmaceuticals Inc
- Dec 20, 2026166dPEDLINAGLIPTINLINAGLIPTINBoehringer Ingelheim Corp
- Dec 20, 2026166dpatentVykat XRdiazoxide choline$SLNOSOLENO THERAPEUTICS INC
- Dec 22, 2026168dI-985Leqvioinclisiran$NVSNOVARTIS AG
- Dec 22, 2026168dpatentIclusigponatinib hydrochloride$TAKTAKEDA PHARMACEUTICAL CO LTD
- Dec 26, 2026172dpatentSymtuza(cobicistat + darunavir + emtricitabine + tenofovir alafenamide)$JNJJOHNSON & JOHNSON
- Dec 26, 2026172dpatentPrezcobix(cobicistat + darunavir)$JNJJOHNSON & JOHNSON
- Dec 26, 2026172dpatentPrezistadarunavirJanssen Therapeutics
- Dec 27, 2026173dODE-283LynparzaolaparibAstraZeneca Pharmaceuticals LP
- Dec 28, 2026174dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Dec 28, 2026174dpatentImbruvicaibrutinib$ABBVAbbVie Inc.
- Dec 30, 2026176dNCE*Recorlevlevoketoconazole$XERSXeris Biopharma Holdings, Inc.
- Jan 1, 2027178dpatentVibativtelavancin hydrochloride$CPIXCUMBERLAND PHARMACEUTICALS INC
- Jan 3, 2027180dPEDNucynta ERtapentadol hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Jan 5, 2027182dpatentZalvisosufentanil citrate$TLPHTALPHERA, INC.
- Jan 6, 2027183dpatentCamptosaririnotecan hydrochloride$PFEPFIZER INC
- Jan 6, 2027183dpatentJatenzotestosterone undecanoate$LPCNLipocine Inc.
- Jan 8, 2027185dM-303METHYLENE BLUEMETHYLENE BLUENexus Pharmaceuticals Inc
- Jan 8, 2027185dpatentHalaveneribulin mesylateEisai Co Ltd
- Jan 8, 2027185dpatentInjectaferferric carboxymaltoseAmerican Regent Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)