the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jun 22, 2027347dODE*Xpovioselinexor$KPTIKaryopharm Therapeutics Inc.
- Jun 25, 2027350dODE-312Finteplafenfluramine hydrochlorideUCB SA
- Jun 26, 2027351dpatentVafseovadadustat$AKBAAkebia Therapeutics, Inc.
- Jun 30, 2027355dpatentApretudecabotegravirViiV Healthcare Company
- Jun 30, 2027355dpatentFomepizolefomepizoleNavinta LLC
- Jun 30, 2027355dODE-311Dojolvitriheptanoin$RAREUltragenyx Pharmaceutical Inc.
- Jul 5, 2027360dpatentDesvenlafaxine Succinatedesvenlafaxine succinateIntellipharmaceutics Ltd
- Jul 7, 2027362dODE-316Inqovi(cedazuridine + decitabine)Otsuka Pharmaceutical Co Ltd
- Jul 10, 2027365dpatentByfavoremimazolam besylateAcacia Pharma Group Ltd
- Jul 11, 20271.0ypatentSpinrazanusinersen$BIIBBIOGEN INC.
- Jul 14, 20271.0ypatentInvokamet XR(canagliflozin + metformin hydrochloride)Johnson & Johnson Innovative Medicine
- Jul 14, 20271.0ypatentCANAGLIFLOZINCANAGLIFLOZINJohnson & Johnson Innovative Medicine
- Jul 20, 20271.0ypatentCalcium Acetatecalcium acetateNostrum Pharmaceuticals LLC
- Jul 21, 20271.0yODE-361Xywavsodium oxybate$JAZZJazz Pharmaceuticals plc
- Jul 22, 20271.0yNPMerzee(ethinylestradiol + norethindrone acetate)Wilshire Pharmaceuticals Inc
- Jul 23, 20271.0ypatentBUPRENORPHINE HYDROCHLORIDEBUPRENORPHINE HYDROCHLORIDEBioDelivery Sciences International Inc
- Jul 23, 20271.0ypatentFentorafentanyl citrateTeva Pharmaceuticals USA Inc
- Jul 23, 20271.0ypatentTpoxxtecovirimat$NNVCNANOVIRICIDES, INC.
- Jul 23, 20271.0ypatentVardenafil Hydrochloridevardenafil hydrochlorideMacleods Pharma USA Inc
- Jul 24, 20271.0ypatentLialdamesalamineTakeda Pharmaceuticals USA Inc
- Jul 28, 20271.0ypatentDopteletavatrombopag maleateSwedish Orphan Biovitrum AB
- Aug 1, 20271.1ypatentSalonpasmethyl salicylate [INN]Hisamitsu America Inc
- Aug 1, 20271.1ypatentELTROMBOPAG OLAMINEELTROMBOPAG OLAMINE$AMRXAmneal Pharmaceuticals, Inc.
- Aug 3, 20271.1ypatentRelistormethylnaltrexone bromideSalix Pharmaceuticals Ltd
- Aug 3, 20271.1ypatentPrednisoneprednisone [INN]Vintage Pharmaceuticals Inc (Inactive)
- Aug 5, 20271.1yODE-315MAGNESIUM SULFATEMAGNESIUM SULFATEMilla Pharmaceuticals Inc
- Aug 6, 20271.1ypatentNinlaroixazomib citrateMillennium Pharmaceuticals Inc
- Aug 6, 20271.1yODE-319Lampitnifurtimox [INN]Bayer HealthCare Pharmaceuticals Inc
- Aug 7, 20271.1yNPDhivy(carbidopa + levodopa)Avion Pharmaceuticals LLC
- Aug 7, 20271.1yI-949Fabhaltaiptacopan hydrochloride$NVSNOVARTIS AG
- Aug 12, 20271.1ypatentIluvienfluocinolone acetonideAlimera Sciences Inc
- Aug 12, 20271.1ypatentRubracarucaparib camsylatepharmaand GmbH
- Aug 12, 20271.1yODE-280ViltepsoviltolarsenNS Pharma Inc
- Aug 13, 20271.1ypatentDesonide ActavisdesonideTeva Pharmaceuticals USA Inc
- Aug 17, 20271.1ypatentXuridenuridine triacetateBTG International Inc
- Aug 19, 20271.1ypatentJuxtapidlomitapideChiesi USA Inc
- Aug 20, 20271.1ypatentFibricorcholine fenofibrateAthena Bioscience LLC
- Aug 24, 20271.1ypatentOXYCODONE HYDROCHLORIDEOXYCODONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Aug 24, 20271.1ypatentHysingla ERhydrocodone bitartratePurdue Pharma LP
- Aug 29, 20271.1yGAINVabomere(meropenem + vaborbactam)A. Menarini Industrie Farmaceutiche Riunite Srl
- Aug 30, 20271.1yM-309Zeposiaozanimod hydrochlorideCelgene Corp
- Sep 1, 20271.1yODE-320OnuregazacitidineBristol-Myers Squibb Co
- Sep 1, 20271.1ypatentNeuprorotigotineUCB SA
- Sep 2, 20271.1ypatentXifaxanrifaximinSalix Pharmaceuticals Ltd
- Sep 3, 20271.2ypatentLEVETIRACETAMLEVETIRACETAMUCB SA
- Sep 4, 20271.2yODE-318Gavretopralsetinib [INN]Blueprint Medicines Corp
- Sep 5, 20271.2ypatentNourianzistradefyllineKyowa Hakko USA Inc
- Sep 9, 20271.2yNCESotyktudeucravacitinibBristol-Myers Squibb Co
- Sep 13, 20271.2yM-308Qsymia(phentermine hydrochloride + topiramate)Vivus LLC
- Sep 14, 20271.2yNCETerlivazterlipressin$BIVIBIOVIE INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)