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  1. pharmadog
  2. ›drugs
  3. ›Lodonal
drug · small molecule
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naltrexone hydrochloride

Marketedupdated 3mo ago
by Biostax Corp🔗 ChEMBL
Approved
community read0 votes

Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for pain and 7 investigational indications.

targets

Opioid receptors; mu/kappa/delta

all catalysts(0)

nothing on the calendar yet

Trials studying naltrexone hydrochloride

  • phase1Study of PF614 Compared to OxyContin® in Healthy Volunteers (PF614-101)completedn=64
  • phase1Evaluation of Oral PF614 Relative to OxyContin (PF614-102)completedn=84
  • phase1Pharmacokinetics of Oxycodone and PF614 Co-Administered with Nafamostat (PF614-MPAR-101)completedn=111

Patent cliff

source: FDA Orange Book
first barrier falls
Dec 12, 2027
~1.3 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (6)

  • Dec 12, 2027formulationUS 78159341.3y
  • Dec 12, 2027formulationUS 78159341.3y
  • Dec 12, 2027formulationUS 78159341.3y
  • Dec 12, 2027formulationUS 78159341.3y
  • Dec 12, 2027formulationUS 78159341.3y
  • Dec 12, 2027formulationUS 78159341.3y

News(0)

no news has mentioned this drug yet

brand
Lodonal
trade names
Adepend, Depade, Nalorex, Naltrexone hydrochloride, Naltrexone hydrochloride component of contrave, Naltrexone hydrochloride component of embeda
generic
naltrexone hydrochloride
MOA
Opioid receptors; mu/kappa/delta antagonist
indication
Autoimmune Hepatitis
phase
marketed
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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