the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Oct 5, 2027339dpatentJuluca(dolutegravir sodium + rilpivirine hydrochloride)ViiV Healthcare Company
- Oct 5, 2027339dpatentTivicaydolutegravir sodiumViiV Healthcare Company
- Oct 13, 2027347dpatentImcivreesetmelanotide$RYTMRHYTHM PHARMACEUTICALS, INC.
- Oct 16, 2027350dNPVyalev(foscarbidopa + foslevodopa)$ABBVAbbVie Inc.
- Oct 16, 2027350dpatentLEVOCETIRIZINE DIHYDROCHLORIDELEVOCETIRIZINE DIHYDROCHLORIDEChattem Inc
- Oct 17, 2027351dpatentLupkynisvoclosporin$AUPHAurinia Pharmaceuticals Inc.
- Oct 27, 2027361dpatentBeleodaqbelinostatAcrotech Biopharma Inc
- Oct 29, 2027363dI-953Scemblixasciminib hydrochloride$NVSNOVARTIS AG
- Oct 30, 2027364dODE-327BronchitolmannitolArna Pharma Pty Ltd
- Nov 1, 20271.0yGAINTalicia(amoxicillin + omeprazole magnesium + rifabutin)$RDHLRedHill Biopharma Ltd.
- Nov 3, 20271.0ypatentRestasiscyclosporine$ABBVAbbVie Inc.
- Nov 8, 20271.0ypatentVALBENAZINE TOSYLATEVALBENAZINE TOSYLATE$NBIXNEUROCRINE BIOSCIENCES INC
- Nov 12, 20271.0ypatentKorsuvadifelikefalinVifor Pharma Inc
- Nov 16, 20271.0ypatentTopiramatetopiramateLP Pharmaceutical (Xiamen) Co Ltd
- Nov 19, 20271.1ypatentRukobiafostemsavir tromethamineViiV Healthcare Company
- Nov 19, 20271.1ypatentVarithenapolidocanolBTG International Inc
- Nov 20, 20271.1ypatentZykadiaceritinib$NVSNOVARTIS AG
- Nov 20, 20271.1yODE-324ZokinvylonafarnibSentynl Therapeutics Inc
- Nov 21, 20271.1ypatentTuraliopexidartinib hydrochlorideDaiichi Sankyo Co Ltd
- Nov 23, 20271.1yODE-339Oxlumolumasiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Nov 26, 20271.1yD-196ACETYLCYSTEINEACETYLCYSTEINEXellia Pharmaceuticals USA LLC
- Dec 1, 20271.1yNCERezlidhiaolutasidenib$RIGLRIGEL PHARMACEUTICALS INC
- Dec 1, 20271.1yODE-329Hetlioztasimelteon$VNDAVanda Pharmaceuticals Inc.
- Dec 3, 20271.1yNPOrladeyoberotralstat hydrochloride$BCRXBIOCRYST PHARMACEUTICALS INC
- Dec 3, 20271.1ypatentCefepime Hydrochloridecefepime hydrochlorideSamson Medical Technologies LLC
- Dec 10, 20271.1ypatentDeoxycholic Aciddeoxycholic acidSlayback Pharma LLC
- Dec 11, 20271.1ypatentAMBRISENTANAMBRISENTANSigmapharm Laboratories LLC
- Dec 11, 20271.1ypatentVALGANCICLOVIR HYDROCHLORIDEVALGANCICLOVIR HYDROCHLORIDENovadoz Pharmaceuticals LLC
- Dec 11, 20271.1ypatentXermelotelotristat ethylTerSera Therapeutics LLC
- Dec 12, 20271.1yNCEKrazatiadagrasibBristol-Myers Squibb Co
- Dec 12, 20271.1ypatentLodonalnaltrexone hydrochlorideBiostax Corp
- Dec 12, 20271.1yNPPSugammadex Sodiumsugammadex sodiumB. Braun Medical Inc
- Dec 18, 20271.1ypatentPIRFENIDONEPIRFENIDONEAizant Drug Research Solutions Pvt Ltd
- Dec 18, 20271.1ypatentTrelegy Ellipta(fluticasone furoate + umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Dec 18, 20271.1ypatentIncruse Elliptaumeclidinium bromideGlaxoSmithKline LLC
- Dec 18, 20271.1yI-955GemtesavibegronSumitomo Pharma America Inc
- Dec 19, 20271.1ypatentTobradex ST(dexamethasone + tobramycin)$HROWHARROW, INC.
- Dec 19, 20271.1yM-187Xofluzabaloxavir marboxil$SGIOFSHIONOGI & CO LTD
- Dec 19, 20271.1ypatentDoxycycline PrascodoxycyclinePrasco LLC
- Dec 20, 20271.1yI-957BraftoviencorafenibArray BioPharma Inc
- Dec 20, 20271.1yM-270SkyclarysomaveloxoloneReata Pharmaceuticals Inc
- Dec 22, 20271.1yNCESunlencalenacapavir sodium$GILDGILEAD SCIENCES, INC.
- Dec 24, 20271.1ypatentNexavarsorafenib tosylateBayer HealthCare Pharmaceuticals Inc
- Dec 25, 20271.2ypatentFINGOLIMOD HYDROCHLORIDEFINGOLIMOD HYDROCHLORIDEEzra Ventures LLC
- Dec 28, 20271.2ypatentBOSENTANBOSENTAN$NSRXNasus Pharma Ltd
- Jan 3, 20281.2ypatentEFINACONAZOLEEFINACONAZOLEOrtho Dermatologics Inc
- Jan 7, 20281.2ypatentTrabectedintrabectedin$JNJJOHNSON & JOHNSON
- Jan 9, 20281.2ypatentActonelrisedronate sodiumAllergan Finance LLC
- Jan 15, 20281.2ypatentNextstellis(drospirenone + estetrol)Mayne Pharma USA Inc
- Jan 16, 20281.2yI-962Lumakrassotorasib$AMGNAMGEN INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)