the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Aug 20, 2027339dpatentFibricorcholine fenofibrateAthena Bioscience LLC
- Aug 24, 2027343dpatentOXYCODONE HYDROCHLORIDEOXYCODONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Aug 24, 2027343dpatentHysingla ERhydrocodone bitartratePurdue Pharma LP
- Aug 29, 2027348dGAINVabomere(meropenem + vaborbactam)A. Menarini Industrie Farmaceutiche Riunite Srl
- Aug 30, 2027349dNPPrevymisletermovirMerck Sharp & Dohme Corp (Inactive)
- Aug 30, 2027349dM-309Zeposiaozanimod hydrochlorideCelgene Corp
- Sep 1, 2027351dODE-320OnuregazacitidineBristol-Myers Squibb Co
- Sep 1, 2027351dpatentNeuprorotigotineUCB SA
- Sep 2, 2027352dpatentXifaxanrifaximinSalix Pharmaceuticals Ltd
- Sep 3, 2027353dpatentLEVETIRACETAMLEVETIRACETAMUCB SA
- Sep 4, 2027354dODE-318Gavretopralsetinib [INN]Blueprint Medicines Corp
- Sep 5, 2027355dpatentNourianzistradefyllineKyowa Hakko USA Inc
- Sep 9, 2027359dNCESotyktudeucravacitinibBristol-Myers Squibb Co
- Sep 13, 2027363dM-308Qsymia(phentermine hydrochloride + topiramate)Vivus LLC
- Sep 14, 2027364dNCETerlivazterlipressin$BIVIBIOVIE INC.
- Sep 15, 2027365dGAINSolosecsecnidazole$EVFMEvofem Biosciences, Inc.
- Sep 17, 20271.0yI-951LETROZOLELETROZOLEYiling Pharmaceutical Ltd
- Sep 17, 20271.0yI-950Kisqaliribociclib succinate$NVSNOVARTIS AG
- Sep 18, 20271.0ypatentAzelexazelaic acidAlmirall SA
- Sep 22, 20271.0yNCEOmlontiomidenepag isopropylOcuvex Therapeutics Inc
- Sep 26, 20271.0ypatentAPREPITANTAPREPITANT$HOTHHoth Therapeutics, Inc.
- Sep 26, 20271.0ypatentArgatrobanargatrobanMylan Institutional Inc
- Sep 27, 20271.0ypatentBetamethasone Dipropionate + Calcipotriene Perrigo(betamethasone dipropionate + calcipotriene)Perrigo New York Inc
- Sep 29, 20271.0yNCESODIUM PHENYLBUTYRATESODIUM PHENYLBUTYRATEHorizon Therapeutics USA Inc
- Sep 30, 20271.0yNCELytgobifutibatinibTaiho Oncology Inc
- Oct 3, 20271.0ypatentTymlosabaloparatideRadius Health Inc
- Oct 3, 20271.0ypatentOnpattropatisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Oct 4, 20271.1yD-194Ameluzaminolevulinic acid hydrochloride$BFRIBiofrontera Inc.
- Oct 4, 20271.1ypatentNebivolol Hydrochloridenebivolol hydrochlorideBeximco Pharmaceuticals USA Inc
- Oct 5, 20271.1ypatentJuluca(dolutegravir sodium + rilpivirine hydrochloride)ViiV Healthcare Company
- Oct 5, 20271.1ypatentTivicaydolutegravir sodiumViiV Healthcare Company
- Oct 13, 20271.1ypatentImcivreesetmelanotide$RYTMRHYTHM PHARMACEUTICALS, INC.
- Oct 16, 20271.1yNPVyalev(foscarbidopa + foslevodopa)$ABBVAbbVie Inc.
- Oct 16, 20271.1ypatentLEVOCETIRIZINE DIHYDROCHLORIDELEVOCETIRIZINE DIHYDROCHLORIDEChattem Inc
- Oct 17, 20271.1ypatentLupkynisvoclosporin$AUPHAurinia Pharmaceuticals Inc.
- Oct 27, 20271.1ypatentBeleodaqbelinostatAcrotech Biopharma Inc
- Oct 30, 20271.1yODE-327BronchitolmannitolArna Pharma Pty Ltd
- Nov 1, 20271.1yGAINTalicia(amoxicillin + omeprazole magnesium + rifabutin)$RDHLRedHill Biopharma Ltd.
- Nov 3, 20271.1ypatentRestasiscyclosporine$ABBVAbbVie Inc.
- Nov 8, 20271.1ypatentVALBENAZINE TOSYLATEVALBENAZINE TOSYLATE$NBIXNEUROCRINE BIOSCIENCES INC
- Nov 12, 20271.2ypatentKorsuvadifelikefalinVifor Pharma Inc
- Nov 16, 20271.2ypatentTopiramatetopiramateLP Pharmaceutical (Xiamen) Co Ltd
- Nov 19, 20271.2ypatentRukobiafostemsavir tromethamineViiV Healthcare Company
- Nov 19, 20271.2ypatentVarithenapolidocanolBTG International Inc
- Nov 20, 20271.2ypatentZykadiaceritinib$NVSNOVARTIS AG
- Nov 20, 20271.2yODE-324ZokinvylonafarnibSentynl Therapeutics Inc
- Nov 21, 20271.2ypatentTuraliopexidartinib hydrochlorideDaiichi Sankyo Co Ltd
- Nov 23, 20271.2yODE-339Oxlumolumasiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Nov 26, 20271.2yD-196ACETYLCYSTEINEACETYLCYSTEINEXellia Pharmaceuticals USA LLC
- Dec 1, 20271.2yNCERezlidhiaolutasidenib$RIGLRIGEL PHARMACEUTICALS INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)