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846 stories matching this filter · ← front page

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  • New home for Novo's Parkinson's cell therapy; GSK's deal to sell drug in China
    Plus, label expansions for two drugs targeting rare diseases, and Genmab scraps a Phase 1 cancer trial: 🧠 Novo's Parkinson's cell therapy finds a biotech home: Novo Nordisk has found a home for…
    Endpoints · 2mo ago↗ source
  • Inhibrx says combo therapy shrank more tumors than Merck's Keytruda alone
    San Diego-based biotech Inhibrx is claiming that it outperformed Merck’s Keytruda in a difficult-to-treat cancer. The combination of Keytruda and Inhibrx’s experimental drug INBRX-106 shrank more…
    Endpoints · 2mo ago↗ source
  • <![CDATA[Treatment Intensification Gains Momentum in mCSPC Management]]>
    <![CDATA[During a recent OncLive Peer Exchange, prostate cancer experts discussed the evolving role of treatment intensification in mCSPC.]]>
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onclive · 2mo ago
↗ source
  • <![CDATA[FDA Approval of Brexu-Cel for R/R MCL Calls for Raised Awareness of CAR T-Cell Therapy Safety Considerations]]>
    <![CDATA[Luhua (Michael) Wang, MD, discusses the FDA approval of brexu-cel in mantle cell lymphoma and what to know about CAR T-cell therapy in clinical practice.]]>
    onclive · 2mo ago↗ source
  • Braveheart Bio's Hengrui-licensed cardiac drug scores second clinical win
    Braveheart Bio said Monday that the heart muscle therapy it licensed from China’s Jiangsu Hengrui Pharmaceuticals has succeeded in a mid-stage trial for the same condition in which Cytokinetics rec…
    Endpoints · 2mo ago↗ source
  • <![CDATA[Dr Randall on the Rationale for Investigating CSF-1R Inhibition in TGCT]]>
    <![CDATA[R. Lor Randall, MD, FACS discusses safety and efficacy data from the MANEUVER trial, which evaluated pimicotinib in TGCT.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Renal Cell Carcinoma: Real-World Factors in First-Line Treatment Selection]]>
    <![CDATA[In this segment, Dr. Elizabeth Plimack and Dr. Yasser Ged discuss how real-world patient factors influence first-line treatment decisions in renal cell carcinoma. ]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Expanding ctDNA Applications to RCC and Germ Cell Tumors]]>
    <![CDATA[Experts explain how ctDNA tracking in metastatic cancer guides therapy tweaks, flags relapse early, and where it fails in brain/peritoneal disease.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[RAPNO Criteria and MRI Assessment in PLGG: Recommendations vs. Real-World Practice]]>
    <![CDATA[Learn how clinicians weigh symptoms, MRI changes and family goals to decide when a child’s tumor needs treatment—beyond simple size cutoffs.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[ctDNA in Metastatic Urothelial Carcinoma]]>
    <![CDATA[Experts explain how ctDNA tracking in metastatic cancer helps tailor immunotherapy, spot relapse early, and guide dose breaks—plus key limitations.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Institutional Perspectives on Treatment Thresholds in PLGG]]>
    <![CDATA[Experts weigh PLGG treatment choices, balancing chemo and MEK inhibitors, guided by vision decline, symptoms, tumor growth, and family logistics.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Renal Cell Carcinoma: Practical Treatment Selection Across Risk Groups]]>
    <![CDATA[In this segment, Dr. Elizabeth Plimack leads a discussion with Dr. Sundhar Ramalingam and Dr. Yasser Ged on how clinicians approach treatment selection in renal cell carcinoma across diffe…
    onclive · 2mo ago↗ source
  • European regulators greenlight Fractyl Health's clinical test of GLP-1 gene therapy
    Drug developers are racing to make gene therapies that could replace chronic GLP-1 injections and pills with a one-and-done treatment. Now, a company based just outside of Boston is poised to becom…
    Endpoints · 2mo ago↗ source
  • CSL sinks to nine-year low on revenue warning, $5B write-down
    CSL's stock hit its lowest price since early 2017 on Monday after it lowered its full-year revenue guidance by about 4% and said it would have to take a new $5 billion impairment charge. The ...
    Endpoints · 2mo ago↗ source
  • <![CDATA[Nivolumab Plus SOC Therapy Shows Encouraging Disease Control in Grade Group 5 Prostate Cancer]]>
    <![CDATA[The regimen produced a 2-year freedom from biochemical recurrence rate of 90.3% in grade group 5 prostate cancer.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Five Under 5: Top Oncology Videos for the Week of 5/3]]>
    <![CDATA[The top 5 OncLive TV videos of the week cover insights in ovarian cancer, classical Hodgkin lymphoma, pancreatic cancer, melanoma, and myelofibrosis.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[ADCs Reshape the Future of Lung Cancer Care: From Second-Line Therapy to Earlier Intervention]]>
    <![CDATA[Judy Wang, MD, discusses how ADCs are transforming NSCLC treatment with improved responses, biomarker-driven care, and CNS activity.]]>
    onclive · 2mo ago↗ source
  • Biotech’s new company model; The super poop behind a startup launch; and more
    Welcome back to another edition of Endpoints Weekly! Earnings season is in full swing, but we had plenty of original reporting and exclusives you won’t find anywhere else this week. Chief among the…
    Endpoints · 2mo ago↗ source
  • <![CDATA[The OncFive: Top Oncology Articles for the Week of 5/3]]>
    <![CDATA[The FDA clears zenocutuzumab in NRG1 fusion+ cholangiocarcinoma, accepts a taletrectinib NDA in ROS1+ NSCLC for review, and more.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Dr Randall on Long-Term Responses and Functional Benefits With Pimicotinib in TGCT]]>
    <![CDATA[R. Lor Randall, MD, FACS discusses safety and efficacy data from the MANEUVER trial, which evaluated pimicotinib in TGCT.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Post–T-DXd Sacituzumab Govitecan Plus Trastuzumab Yields Low ORR in HER2+ Metastatic Breast Cancer]]>
    <![CDATA[Sacituzumab govitecan plus trastuzumab following T-DXd did not meet the primary end point of the SATEEN trial in HER2+ metastatic breast cancer.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Dr Sznol on the Nuances of Recommending Neoadjuvant Therapy in Metastatic Melanoma]]>
    <![CDATA[Mario Sznol, MD, discusses current guidance around the use of neoadjuvant therapy in advanced melanoma. ]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Biomarker-Directed Therapies Move the GI Oncology Paradigm Beyond a One-Size-Fits-All Approach: With Michael J. Pishvaian, MD, PhD]]>
    <![CDATA[Michael J. Pishvaian, MD, PhD discusses how biomarker-directed strategies, including HER2, CLDN18.2, and KRAS inhibition, are transforming GI cancer care.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[Capivasertib/Fulvestrant Yields Numerical OS Advantage in PIK3CA/AKT1/PTEN–Altered Breast Cancer]]>
    <![CDATA[Capivasertib plus fulvestrant generated a numerical OS benefit vs placebo plus fulvestrant in PIK3CA/AKT1/PTEN-altered advanced breast cancer.]]>
    onclive · 2mo ago↗ source
  • <![CDATA[FDA Approves Zenocutuzumab for NRG1 Fusion+ Cholangiocarcinoma ]]>
    <![CDATA[]]>
    onclive · 2mo ago↗ source