<![CDATA[Expanding ctDNA Applications to RCC and Germ Cell Tumors]]>

Advertisement Opinion|Videos|May 11, 2026 Expanding ctDNA Applications to RCC and Germ Cell Tumors Author(s)Pooja Ghatalia, M.D. , Steven Seyedin, M.D. , Arnab Basu, M.D. Experts explain how ctDNA tracking in metastatic cancer guides therapy tweaks, flags relapse early, and where it fails in brain/peritoneal disease. Advertisement Episodes in this seriesEP. 1 Early Adoption of ctDNA in Muscle-Invasive Bladder CancerEP. 2 Integrating ctDNA Into Clinical Decision-MakingEP. 3 ctDNA in the Perioperative SettingEP. 4 Practical Considerations for ctDNA TestingEP. 5 ctDNA in Chemoradiotherapy and Bladder PreservationEP. 6 Emerging Role of Urinary Tumor DNA (utDNA)EP. 7 ctDNA in Metastatic Urothelial CarcinomaNow PlayingEP. 8 Expanding ctDNA Applications to RCC and Germ Cell Tumors The discussion expands beyond bladder cancer to explore the role of ctDNA in renal cell carcinoma (RCC) and germ cell tumors. In RCC, ctDNA adoption has been limited due to lower tumor shedding, but emerging assays and complementary biomarkers such as KIM-1 are showing promise for risk stratification and recurrence prediction. In germ cell tumors, ctDNA and microRNA-based assays demonstrate strong prognostic potential, particularly in the adjuvant setting and for evaluating residual disease. However, these approaches remain investigational, and clinicians emphasize the need for larger prospective studies. This segment highlights the biological diversity across GU malignancies and the importance of tailoring molecular monitoring strategies to each disease type, as ctDNA technologies continue to evolve. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementRAPNO Criteria and MRI Assessment in PLGG: Recommendations vs. Real-World PracticeByMohamed Abdelbaki, MD,Susan N. 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