<![CDATA[ctDNA in Metastatic Urothelial Carcinoma]]>

Advertisement Opinion|Videos|May 11, 2026 ctDNA in Metastatic Urothelial Carcinoma Author(s)Pooja Ghatalia, M.D. , Steven Seyedin, M.D. , Arnab Basu, M.D. Experts explain how ctDNA tracking in metastatic cancer helps tailor immunotherapy, spot relapse early, and guide dose breaks—plus key limitations. Advertisement Episodes in this seriesEP. 1 Early Adoption of ctDNA in Muscle-Invasive Bladder CancerEP. 2 Integrating ctDNA Into Clinical Decision-MakingEP. 3 ctDNA in the Perioperative SettingEP. 4 Practical Considerations for ctDNA TestingEP. 5 ctDNA in Chemoradiotherapy and Bladder PreservationEP. 6 Emerging Role of Urinary Tumor DNA (utDNA)Now PlayingEP. 7 ctDNA in Metastatic Urothelial CarcinomaEP. 8 Expanding ctDNA Applications to RCC and Germ Cell Tumors This segment examines the use of ctDNA in metastatic urothelial carcinoma, particularly for monitoring treatment response and guiding therapeutic decisions. Panelists describe how ctDNA dynamics often correlate with clinical and radiographic outcomes, with rapid declines indicating favorable response and persistent positivity suggesting resistance. ctDNA is also used to support decisions around treatment de-escalation, especially in patients experiencing toxicity from regimens such as enfortumab vedotin plus pembrolizumab. Additionally, ctDNA may detect molecular recurrence earlier than imaging, allowing for more timely intervention. However, clinicians caution that ctDNA has limitations, including reduced sensitivity in certain metastatic sites. Overall, this segment highlights ctDNA as a promising real-time biomarker in advanced disease, with growing clinical utility in personalized treatment management. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! 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