the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 19, 20314.2ypatentZypitamagpitavastatin [INN]$MCUJFMEDICURE INC
- Jan 20, 20314.2ypatentPradaxadabigatran etexilate mesylateBoehringer Ingelheim Corp
- Jan 26, 20314.2ypatentInvega Sustennapaliperidone palmitateJohnson & Johnson Innovative Medicine
- Feb 4, 20314.3ypatentVocabriacabotegravir sodiumViiV Healthcare Company
- Feb 24, 20314.3ypatentSymproicnaldemedine tosylateBioDelivery Sciences International Inc
- Mar 2, 20314.3ypatentLevomilnacipran Hydrochloridelevomilnacipran hydrochloridePrinston Pharmaceutical Inc
- Mar 10, 20314.4ypatentBarhemsysamisulpride [INN]Acacia Pharma Group Ltd
- Apr 3, 20314.4ypatentAustedo XRdeutetrabenazineTeva Neuroscience Inc
- Apr 30, 20314.5ypatentYuviwelnavepegritideAscendis Pharma AS
- May 18, 20314.5ypatentSolifenacin Succinatesolifenacin succinateNovadoz Pharmaceuticals LLC
- Jun 11, 20314.6ypatentSunosisolriamfetol hydrochloride$AXSMAxsome Therapeutics, Inc.
- Jul 15, 20314.7ypatentPHENYLEPHRINE HYDROCHLORIDEPHENYLEPHRINE HYDROCHLORIDECaplin Steriles Ltd
- Jul 17, 20314.7ypatentQvar Redihalerbeclomethasone dipropionateTeva Respiratory LLC
- Jul 19, 20314.7ypatentAklieftrifaroteneGalderma Laboratories LP
- Aug 6, 20314.8ypatentEuthyroxlevothyroxine sodiumEMD Serono Inc
- Aug 7, 20314.8ypatentDocivyxdocetaxelMeridian Laboratories Inc
- Aug 8, 20314.8ypatentEcozaeconazole nitrateResilia Pharmaceuticals Inc
- Aug 23, 20314.8ypatentLybalvi(olanzapine + samidorphan l-malate)$ALKSAlkermes plc.
- Sep 6, 20314.9ypatentLynavoylinerixibatGlaxoSmithKline LLC
- Sep 8, 20314.9ypatentFebuxostatfebuxostatNovadoz Pharmaceuticals LLC
- Sep 20, 20314.9ypatentDayvigolemborexantEisai Co Ltd
- Sep 28, 20314.9ypatentVerzenioabemaciclibEli Lilly and Co
- Oct 10, 20314.9ypatentCleviprexclevidipineChiesi USA Inc
- Oct 22, 20315.0ypatentAngeliq(drospirenone + estradiol)Bayer HealthCare Pharmaceuticals Inc
- Oct 25, 20315.0ypatentCoselatrilaciclibPharmacosmos AS
- Oct 31, 20315.0ypatentMytesicrofelemerNapo Pharmaceuticals Inc
- Nov 2, 20315.0ypatentDuobrii(halobetasol propionate + tazarotene)Ortho Dermatologics Inc
- Nov 2, 20315.0ypatentHalobetasol Propionatehalobetasol propionateG&W Laboratories Inc
- Nov 10, 20315.0ypatentQuliptaatogepant$ABBVAbbVie Inc.
- Nov 10, 20315.0ypatentUbrelvyubrogepant$ABBVAbbVie Inc.
- Dec 5, 20315.1ypatentALENDRONATE SODIUMALENDRONATE SODIUMIpca Pharmaceuticals Inc
- Dec 19, 20315.1yODE-515Tryngolzaolezarsen sodium$IONSIONIS PHARMACEUTICALS INC
- Jan 3, 20325.2ypatentTuxarin ER(chlorpheniramine maleate + codeine [INN])MainPointe Pharmaceuticals LLC
- Jan 4, 20325.2ypatentDEXMEDETOMIDINE HYDROCHLORIDEDEXMEDETOMIDINE HYDROCHLORIDEHQ Speciality Pharma
- Feb 10, 20325.3ypatentLokelmasodium zirconium cyclosilicateAstraZeneca Pharmaceuticals LP
- Mar 2, 20325.3ypatentNeoprofenibuprofen lysineRecordati Rare Diseases Inc
- Mar 9, 20325.4ypatentAscorascorbic acid [INN]Renovion Inc
- Mar 23, 20325.4ypatentOLINVYKOLICERIDINETrevena Inc
- Mar 23, 20325.4ypatentJornay PMmethylphenidate hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Apr 23, 20325.5ypatentHYDROMORPHONE HYDROCHLORIDEHYDROMORPHONE HYDROCHLORIDEFresenius Kabi USA LLC
- May 10, 20325.5ypatentTemsirolimustemsirolimusAccord Healthcare Inc
- May 19, 20325.6ypatentPatadayolopatadine hydrochlorideAlcon Laboratories Inc
- Jun 22, 20325.6ypatentDefiteliodefibrotide sodium$JAZZJazz Pharmaceuticals plc
- Jun 28, 20325.7ypatentCotempla XR-ODTmethylphenidate hydrochloride$AYTUAYTU BIOPHARMA, INC
- Jun 29, 20325.7ypatentFirdapseamifampridine phosphate$CPRXCATALYST PHARMACEUTICALS, INC.
- Jul 27, 20325.7ypatentAzstarys(dexmethylphenidate hydrochloride + serdexmethylphenidate chloride)Corium LLC
- Aug 15, 20325.8ypatentOdefsey(emtricitabine + rilpivirine hydrochloride + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Aug 30, 20325.8ypatentDelstrigo(doravirine + lamivudine + tenofovir disoproxil fumarate)Merck Sharp & Dohme Corp (Inactive)
- Aug 30, 20325.8ypatentPifeltrodoravirineMerck Sharp & Dohme Corp (Inactive)
- Sep 27, 20325.9ypatentVizimprodacomitinib$PFEPFIZER INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)