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  1. pharmadog
  2. ›drugs
  3. ›Lokelma
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sodium zirconium cyclosilicate

Marketedupdated 4mo ago
by AstraZeneca Pharmaceuticals LP
Approved
community read0 votes

all catalysts(0)

nothing on the calendar yet

Trials studying sodium zirconium cyclosilicate

  • phase3An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemiarecruitingn=140
  • phase3A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemiaterminatedn=1,112
  • —A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in Greececompletedn=125
  • phase4Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Studycompletedn=186
  • phase4Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactonecompletedn=366
  • phase2OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failureactive not recruitingn=110
  • phase3Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)terminatedn=2,690
  • phase3A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia.completedn=270
more trials →

Patent cliff

source: FDA Orange Book
first barrier falls
Feb 10, 2032
~5.5 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (27)

  • Oct 14, 2035compositionUS 10300087
  • Oct 14, 2035compositionUS 10300087
  • Oct 14, 2035method-of-use (U-2312)US 11738044
  • Oct 14, 2035method-of-use (U-2312)US 11738044
  • Oct 14, 2035compositionUS 9592253
  • Oct 14, 2035compositionUS 9592253
  • Oct 22, 2033compositionUS 10695365
  • Oct 22, 2033compositionUS 10695365
  • Oct 22, 2033compositionUS 8877255
  • Oct 22, 2033compositionUS 8877255
  • Oct 22, 2033compositionUS 9913860
  • Oct 22, 2033compositionUS 9913860
  • Apr 19, 2032compositionUS 8802152
  • Apr 19, 2032compositionUS 8802152
  • Feb 10, 2032method-of-use (U-2312)US 10335432
  • Feb 10, 2032method-of-use (U-2312)US 10398730
  • Feb 10, 2032method-of-use (U-2312)US 10398730
  • Feb 10, 2032compositionUS 10413569
  • Feb 10, 2032compositionUS 10413569
  • Feb 10, 2032compositionUS 11406662
  • Feb 10, 2032compositionUS 11406662
  • Feb 10, 2032method-of-use (U-2312)US 8808750
  • Feb 10, 2032method-of-use (U-2312)US 8808750
  • Feb 10, 2032method-of-use (U-2312)US 9844567
  • Feb 10, 2032method-of-use (U-2312)US 9844567
  • Feb 10, 2032method-of-use (U-2312)US 9861658
  • Feb 10, 2032method-of-use (U-2312)US 9861658

News(0)

no news has mentioned this drug yet

brand
Lokelma
generic
sodium zirconium cyclosilicate
indication
Hyperkalemia
phase
marketed
Data sources
ClinicalTrials.gov
last refreshed 28m ago
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