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drugs
ALENDRONATE SODIUM

drug

ALENDRONATE SODIUM

Marketedupdated 3mo ago

by Ipca Pharmaceuticals Inc

Approved

community read0 votes

🐶 often sniffed alongside

top 7

tagApproval220 co-mentions · 110 sources
drugFOSAMAX195 co-mentions · 110 sources
drugFOSAMAX PLUS D195 co-mentions · 110 sources
tagSmall Molecule110 co-mentions · 110 sources
drug(alendronate sodium + cholecalciferol)18 co-mentions · 18 sources
companyAurobindo Pharma Ltd15 co-mentions · 15 sources
companyNovitium Pharma LLC2 co-mentions · 2 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 2 investigational indications.

all catalysts(77)

approval · 77

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

FOSAMAX (ALENDRONATE SODIUM) — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

ALENDRONATE SODIUM — FDA approval

ALENDRONATE SODIUM

view all 77 catalysts →

Trials studying ALENDRONATE SODIUM

phase3A Study to Evaluate the Safety and Tolerability of MK0217 in Women (0217-219)completedn=454
phase3A Study and 12 Month Extension to Evaluate Two Investigational Drugs in Postmenopausal Women With Osteoporosis (MK-0217-907)completedn=936
phase3A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)completedn=717
phase3A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262)completedn=515
phase4Efficacy and Safety Study of Fosamax Plus D in Postmenopausal Women With Osteoporosis (0217A-263)completedn=343
phase3Study of MK-217A/Alendronate Sodium 70-mg/Vitamin D3 5600 IU Combination Tablet (MK-0217A-329)completedn=200

Patent cliff

source: FDA Orange Book

first barrier falls

Dec 5, 2031

~5.3 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (1)

Dec 5, 2031formulationUS 9592195

News(0)

no news has mentioned this drug yet

brand

ALENDRONATE SODIUM

generic

ALENDRONATE SODIUM

MOA

12.1 Mechanism of Action Alendronate Sodium Animal studies have indicated the following mode of action. At the cellular level, alendronate shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. Studies in mice on the localization of radioactive [ 3 H]alendronate in bone showed about 10-fold higher uptake on osteoclast surfaces than on osteoblast surfaces. Bones examined 6 and 49 days after [ 3 H]alendronate administration in rats and mice, respectively, showed that normal bone was formed on top of the alendronate, which was incorporated inside the matrix. While incorporated in bone matrix, alendronate is not pharmacologically active. Thus, alendronate must be continuously administered to suppress osteoclasts on newly formed resorption surfaces. Histomorphometry in baboons and rats showed that alendronate treatment reduces bone turnover (i.e., the number of sites at which bone is remodeled). In addition, bone formation exceeds bone resorption at these remodeling sites, leading to progressive gains in bone mass. Cholecalciferol Vitamin D 3 is produced in the skin by photochemical conversion of 7-dehydrocholesterol to previtamin D 3 by ultraviolet light. This is followed by non-enzymatic isomerization to vitamin D 3 . In the absence of adequate sunlight exposure, vitamin D 3 is an essential dietary nutrient. Vitamin D 3 in skin and dietary vitamin D 3 (absorbed into chylomicrons) is converted to 25-hydroxyvitamin D 3 in the liver. Conversion to the active calcium-mobilizing hormone 1,25-dihydroxyvitamin D 3 (calcitriol) in the kidney is stimulated by both parathyroid hormone and hypophosphatemia. The principal action of 1,25-dihydroxyvitamin D 3 is to increase intestinal absorption of both calcium an

indication

Glucocorticoid-Induced Osteoporosis

phase

marketed

Data sources

openFDA · ClinicalTrials.gov

last refreshed 25m ago

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