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  1. pharmadog
  2. ›drugs
  3. ›Pifeltro
drug
save

doravirine

Marketedupdated 3mo ago
by Merck Sharp & Dohme Corp (Inactive)
Approved
community read0 votes

🐶 often sniffed alongside

top 8
  • drugDELSTRIGO39 co-mentions · 14 sources
  • tagApproval38 co-mentions · 13 sources
  • drugPIFELTRO32 co-mentions · 14 sources
  • tagSmall Molecule19 co-mentions · 13 sources
  • drug(doravirine + lamivudine + tenofovir disoproxil fumarate)7 co-mentions · 7 sources
  • tagInfectious Disease1 co-mentions · 1 sources
  • tagPDUFA1 co-mentions · 1 sources
  • drug(doravirine + islatravir hydrate)1 co-mentions · 1 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 1 investigational indication.

all catalysts(6)

approval · 6
Aug 30, 2018
approval
$MRK130.42-0.38%
8y ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→
Sep 19, 2019
approval
$MRK130.42-0.38%
7y ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→
Oct 10, 2019
approval
$MRK130.42-0.38%
7y ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→
Jan 27, 2022
approval
$MRK130.42-0.38%
5y ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→
Nov 7, 2024
approval
$MRK130.42-0.38%
2y ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→
Oct 29, 2025
approval
$MRK130.42-0.38%
10mo ago
PIFELTRO (DORAVIRINE) — FDA approval
doravirine
→

Trials studying doravirine

  • phase1Single Dose Pharmacokinetics of Doravirine in HIV-infected Pregnant Womencompletedn=7
  • phase4Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteerscompletedn=20
  • phase2Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)recruitingn=84
  • EP1Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIVcompletedn=26
  • phase4Efficacy and Safety of Doravirine in the Rapid Initiationnot yet recruitingn=100
  • phase3DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infectionrecruitingn=610
  • —Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartumcompletedn=205
  • phase2DOR/TDF/3TC Switch With M184V/I in People With Controlled HIV (Drive Off-Road)recruitingn=32
more trials →

Patent cliff

source: FDA Orange Book
first barrier falls
Aug 30, 2032
~6.1 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (1)

  • Aug 30, 2032compositionUS 8486975

News(1)

  • Merck adds to pharma’s AI push; Roche details MS drug results
    Merck is making a $1 billion investment in a deal with Google Cloud. Elsewhere, Roche pitched its case for a closely watched multiple sclerosis pill and Arcus and Gilead are ending a yearslong alli…
    biopharma_dive · 3mo ago
brand
Pifeltro
generic
doravirine
MOA
12.1 Mechanism of Action Doravirine is an antiretroviral drug [see Microbiology (12.4) ].
indication
Human Immunodeficiency Virus (HIV) Infections (AIDS)
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 26m ago
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