drug · small molecule

PIFELTRO

updated 5mo ago

by $MRK Merck & Co., Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 1 investigational indication.

targets

Human immunodeficiency virus type 1 reverse transcriptase

all catalysts(0)

nothing on the calendar yet

Trials studying PIFELTRO

phase4Efficacy and Safety of Doravirine in the Rapid Initiationrecruitingn=100
phase1Single Dose Pharmacokinetics of Doravirine in HIV-infected Pregnant Womencompletedn=7
phase4Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteerscompletedn=20
phase2Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)recruitingn=84
EP1Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIVcompletedn=26
phase3DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infectionrecruitingn=610
—Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartumcompletedn=205
phase2DOR/TDF/3TC Switch With M184V/I in People With Controlled HIV (Drive Off-Road)recruitingn=32

News(1)

Merck adds to pharma’s AI push; Roche details MS drug results
Merck is making a $1 billion investment in a deal with Google Cloud. Elsewhere, Roche pitched its case for a closely watched multiple sclerosis pill and Arcus and Gilead are ending a yearslong alli…
biopharma_dive · 5mo ago

brand

PIFELTRO

trade names

Doravirine component of delstrigo, Pifeltro

generic

DORAVIRINE

MOA

12.1 Mechanism of Action Doravirine is an antiretroviral drug [see Microbiology (12.4) ].

indication

1 INDICATIONS AND USAGE PIFELTRO ® is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg: with no prior antiretroviral treatment history; OR to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine [see Clinical Studies (14) ] . PIFELTRO, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg: with no prior antiretroviral treatment history, OR to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine. ( 1 )

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 2h ago

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drug · small molecule

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PIFELTRO

updated 5mo ago

by $MRK Merck & Co., Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 8

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 1 investigational indication.

targets

Human immunodeficiency virus type 1 reverse transcriptase

all catalysts(0)

nothing on the calendar yet

Trials studying PIFELTRO

phase4Efficacy and Safety of Doravirine in the Rapid Initiationrecruitingn=100
phase1Single Dose Pharmacokinetics of Doravirine in HIV-infected Pregnant Womencompletedn=7
phase4Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteerscompletedn=20
phase2Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)recruitingn=84
EP1Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIVcompletedn=26
phase3DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infectionrecruitingn=610
—Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartumcompletedn=205
phase2DOR/TDF/3TC Switch With M184V/I in People With Controlled HIV (Drive Off-Road)recruitingn=32

News(1)

Merck adds to pharma’s AI push; Roche details MS drug results
Merck is making a $1 billion investment in a deal with Google Cloud. Elsewhere, Roche pitched its case for a closely watched multiple sclerosis pill and Arcus and Gilead are ending a yearslong alli…
biopharma_dive · 5mo ago

brand

PIFELTRO

trade names

Doravirine component of delstrigo, Pifeltro

generic

DORAVIRINE

MOA

12.1 Mechanism of Action Doravirine is an antiretroviral drug [see Microbiology (12.4) ].

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 2h ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

PIFELTRO

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying PIFELTRO

News(1)

Report a data issue

comments(0)

PIFELTRO

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying PIFELTRO

News(1)

Report a data issue

comments(0)