drug · small molecule

PIFELTRO

updated 2mo ago

by $MRK Merck & Co., Inc.🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 1 investigational indication.

targets

Human immunodeficiency virus type 1 reverse transcriptase

all catalysts(0)

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brand

PIFELTRO

trade names

Doravirine component of delstrigo, Pifeltro

generic

DORAVIRINE

MOA

12.1 Mechanism of Action Doravirine is an antiretroviral drug [see Microbiology (12.4) ].

indication

1 INDICATIONS AND USAGE PIFELTRO ® is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg: with no prior antiretroviral treatment history; OR to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine [see Clinical Studies (14) ] . PIFELTRO, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg: with no prior antiretroviral treatment history, OR to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine. ( 1 )

PIFELTRO

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Trials studying PIFELTRO