the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Aug 16, 202634dODE-259InrebicfedratinibBristol-Myers Squibb Co
- Aug 18, 202636dI-925VALBENAZINE TOSYLATEVALBENAZINE TOSYLATE$NBIXNEUROCRINE BIOSCIENCES INC
- Aug 18, 202636dpatentFarxigadapagliflozin propanediol$AZNASTRAZENECA PLC
- Aug 18, 202636dpatentOrserduelacestrant hydrochlorideA. Menarini Industrie Farmaceutiche Riunite Srl
- Aug 22, 202640dODE-260Tybostcobicistat$GILDGILEAD SCIENCES, INC.
- Aug 22, 202640dpatentIvabradine Hydrochlorideivabradine hydrochlorideIngenus Pharmaceuticals LLC
- Aug 23, 202641dNCEKorsuvadifelikefalinVifor Pharma Inc
- Aug 23, 202641dpatentIsturisaosilodrostat phosphateRecordati Rare Diseases Inc
- Aug 23, 202641dM-232Trintellixvortioxetine hydrobromideTakeda Pharmaceuticals USA Inc
- Aug 24, 202642dpatentDymista(azelastine hydrochloride + fluticasone propionate)Mylan Pharmaceuticals Inc
- Aug 24, 202642dpatentXtandienzalutamideAlessa Therapeutics Inc
- Aug 24, 202642dpatentNuplazidpimavanserin tartrate$ACADACADIA PHARMACEUTICALS INC
- Aug 26, 202644dpatentFluticasone Propionatefluticasone propionateGlenmark Pharmaceuticals Ltd
- Aug 27, 202645dpatentGenvoya(cobicistat + elvitegravir + emtricitabine + tenofovir alafenamide fumarate)$GILDGILEAD SCIENCES, INC.
- Aug 27, 202645dpatentStribild(cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Aug 28, 202646dODE*Harvoni(ledipasvir + sofosbuvir)$GILDGILEAD SCIENCES, INC.
- Aug 28, 202646dpatentNexplanonetonogestrel$DAREDare Bioscience, Inc.
- Aug 28, 202646dODE*Sovaldisofosbuvir$GILDGILEAD SCIENCES, INC.
- Aug 29, 202647dpatentNebivolol Hydrochloridenebivolol hydrochlorideBeximco Pharmaceuticals USA Inc
- Aug 30, 202648dODE-296POMALIDOMIDEPOMALIDOMIDECelgene Corp
- Aug 30, 202648dpatentLinzesslinaclotide$ABBVAbbVie Inc.
- Sep 1, 202650dpatentTOLVAPTANTOLVAPTANOtsuka America Pharmaceutical Inc
- Sep 6, 202655dODE-261Ofevnintedanib esylateBoehringer Ingelheim Corp
- Sep 9, 202658dpatentRyteloimetelstat sodium$GERNGERON CORP
- Sep 11, 202660dpatentOpsynvi(macitentan + tadalafil)Janssen Biotech Inc
- Sep 11, 202660dpatentMACITENTANMACITENTAN$JNJJOHNSON & JOHNSON
- Sep 12, 202661dpatentRezdiffraresmetirom$MDGLMADRIGAL PHARMACEUTICALS, INC.
- Sep 12, 202661dpatentTeriflunomideteriflunomideSOLA Pharmaceuticals Inc
- Sep 15, 202664dpatentAdapaleneadapalenePL Developments Copiague LLC
- Sep 15, 202664dpatentLynkuetelinzanetantBayer USA LLC
- Sep 16, 202665dCGTCITALOPRAM HYDROBROMIDECITALOPRAM HYDROBROMIDEInvaGen Pharmaceuticals Inc
- Sep 16, 202665dODE-428Mekinisttrametinib dimethyl sulfoxide$NVSNOVARTIS AG
- Sep 16, 202665dODE-428Tafinlardabrafenib mesylate$NVSNOVARTIS AG
- Sep 19, 202668dpatentLenvimalenvatinib mesylateEisai Co Ltd
- Sep 21, 202670dI-922SYNJARDYEMPAGLIFLOZINBoehringer Ingelheim Corp
- Sep 22, 202671dpatentCINACALCET HYDROCHLORIDECINACALCET HYDROCHLORIDESlate Run Pharmaceuticals LLC
- Sep 22, 202671dpatentPIRFENIDONEPIRFENIDONEAizant Drug Research Solutions Pvt Ltd
- Sep 25, 202674dNPRyzumviphentolamine mesylate$IRDOpus Genetics, Inc.
- Sep 26, 202675dI-923BosutinibbosutinibAlembic Pharmaceuticals Inc
- Sep 26, 202675dpatentRisperidonerisperidoneSenores Pharmaceuticals Inc
- Sep 28, 202677dpatentDASATINIBDASATINIBXspray Pharma AB
- Sep 28, 202677dNCEQuliptaatogepant$ABBVAbbVie Inc.
- Sep 28, 202677dNPOpfoldamiglustatBiocodex
- Sep 29, 202678dI-938Livmarlimaralixibat chloride$MIRMMirum Pharmaceuticals, Inc.
- Oct 2, 202681dNPPVeltassapatiromer sorbitex calciumVifor Pharma Inc
- Oct 2, 202681dpatentVeregensinecatechins$ANIPANI PHARMACEUTICALS INC
- Oct 3, 202682dM-270EVRYSDIRISDIPLAMGenentech Inc
- Oct 3, 202682dODE-271Hemadydexamethasone [INN]Fera Pharmaceuticals LLC
- Oct 4, 202683dpatentAriceptdonepezil hydrochlorideEisai Co Ltd
- Oct 4, 202683dpatentMethotrexate Sodiummethotrexate$PFEPFIZER INC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)