the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Dec 12, 202642dpatentEpinephrineepinephrineInternational Medication Systems Ltd
- Dec 12, 202642dODE-280Vyondys 53golodirsen$SRPTSarepta Therapeutics, Inc.
- Dec 12, 202642dpatentIvabradine Hydrochlorideivabradine hydrochlorideIngenus Pharmaceuticals LLC
- Dec 12, 202642dpatentNarcannaloxone hydrochlorideEmergent Devices Inc
- Dec 12, 202642dpatentKoselugoselumetinib sulfateAstraZeneca Pharmaceuticals LP
- Dec 13, 202643dNPTRAVOPROSTTRAVOPROSTSandoz Inc
- Dec 13, 202643dNPIwilfineflornithine hydrochlorideUS WorldMeds LLC
- Dec 14, 202644dI-931Weliregbelzutifan$MRKMerck & Co., Inc.
- Dec 14, 202644dpatentSigniforpasireotideRecordati Corp
- Dec 15, 202645dPEDTriumeq(abacavir sulfate + dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Dec 15, 202645dI-969Zoryveroflumilast$ARQTArcutis Biotherapeutics, Inc.
- Dec 16, 202646dpatentInrebicfedratinibBristol-Myers Squibb Co
- Dec 17, 202647dpatentTrintellixvortioxetine hydrobromideTakeda Pharmaceuticals USA Inc
- Dec 19, 202649dpatentLatissebimatoprost$ABBVAbbVie Inc.
- Dec 19, 202649dpatentVyndamaxtafamidis$PFEPFIZER INC
- Dec 20, 202650dPEDSynjardy XR(empagliflozin + metformin hydrochloride)Boehringer Ingelheim Corp
- Dec 20, 202650dPEDLinagliptin + Metformin Hydrochloride(linagliptin + metformin hydrochloride)MSN Pharmaceuticals Inc
- Dec 20, 202650dPEDLINAGLIPTINLINAGLIPTINBoehringer Ingelheim Corp
- Dec 20, 202650dPEDSYNJARDYEMPAGLIFLOZINBoehringer Ingelheim Corp
- Dec 20, 202650dpatentVykat XRdiazoxide choline$SLNOSOLENO THERAPEUTICS INC
- Dec 22, 202652dI-985Leqvioinclisiran$NVSNOVARTIS AG
- Dec 22, 202652dpatentIclusigponatinib hydrochloride$TAKTAKEDA PHARMACEUTICAL CO LTD
- Dec 26, 202656dpatentSymtuza(cobicistat + darunavir + emtricitabine + tenofovir alafenamide)$JNJJOHNSON & JOHNSON
- Dec 26, 202656dpatentPrezcobix(cobicistat + darunavir)$JNJJOHNSON & JOHNSON
- Dec 26, 202656dpatentPrezistadarunavirJanssen Therapeutics
- Dec 27, 202657dpatentRyteloimetelstat sodium$GERNGERON CORP
- Dec 27, 202657dODE-283LynparzaolaparibAstraZeneca Pharmaceuticals LP
- Dec 28, 202658dpatentAlyftrek(deutivacaftor + tezacaftor + vanzacaftor calcium)$VERXVertex, Inc.
- Dec 28, 202658dpatentTRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR$VERXVertex, Inc.
- Dec 28, 202658dpatentImbruvicaibrutinib$ABBVAbbVie Inc.
- Dec 30, 202660dNCE*Recorlevlevoketoconazole$XERSXeris Biopharma Holdings, Inc.
- Jan 1, 202762dpatentVibativtelavancin hydrochloride$CPIXCUMBERLAND PHARMACEUTICALS INC
- Jan 3, 202764dPEDNucynta ERtapentadol hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Jan 5, 202766dpatentZalvisosufentanil citrate$TLPHTALPHERA, INC.
- Jan 6, 202767dpatentCamptosaririnotecan hydrochloride$PFEPFIZER INC
- Jan 6, 202767dpatentJatenzotestosterone undecanoate$LPCNLipocine Inc.
- Jan 8, 202769dM-303METHYLENE BLUEMETHYLENE BLUENexus Pharmaceuticals Inc
- Jan 8, 202769dpatentHalaveneribulin mesylateEisai Co Ltd
- Jan 8, 202769dpatentInjectaferferric carboxymaltoseAmerican Regent Inc
- Jan 9, 202770dODE-356AyvakitavapritinibBlueprint Medicines Corp
- Jan 10, 202771dNPPDIAZEPAMDIAZEPAMMylan Institutional Inc
- Jan 10, 202771dpatentSublocadebuprenorphine [INN]$INDVIndivior Pharmaceuticals, Inc.
- Jan 12, 202773dpatentWinleviclascoteroneSun Pharmaceutical Industries Ltd
- Jan 13, 202774dPEDVekluryremdesivir$GILDGILEAD SCIENCES, INC.
- Jan 14, 202775dNCECibinqoabrocitinib$PFEPFIZER INC
- Jan 15, 202776dpatentDuvyzatgivinostat hydrochlorideItalfarmaco SpA
- Jan 16, 202777dpatentCamcevileuprolide mesylateForesee Pharmaceuticals Co Ltd
- Jan 18, 202779dpatentNILOTINIB HYDROCHLORIDENILOTINIB HYDROCHLORIDEHetero Labs Ltd
- Jan 18, 202779dI-937Piqrayalpelisib$NVSNOVARTIS AG
- Jan 19, 202780dpatentStiolto Respimat(olodaterol hydrochloride + tiotropium bromide)Boehringer Ingelheim Corp
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)