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  1. pharmadog
  2. ›drugs
  3. ›Vyndamax
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tafamidis

Marketedupdated 5mo ago
by $PFE PFIZER INC
Approved
community read0 votes

all catalysts(0)

nothing on the calendar yet

Trials studying tafamidis

  • —Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin Amyloid Cardiomyopathycompletedn=110
  • —A Retrospective Observational Study of Epidemiology and Outcomes in Transthyretin Amyloid Cardiomyopathy in Germanyrecruitingn=1
  • phase1A Study to Compare the Amount of Two Forms of Tafamidis in the Blood of Healthy Adults Under Fed Conditionsrecruitingn=24
  • —Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Transthyretin Amyloid Cardiomyopathycompletedn=50
  • —A Study to Learn About the Study Medicine Called Tafamidis 61mg in People Diagnosed With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)completedn=13
  • —A Study to Learn About Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in Indiacompletedn=6
  • phase4To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients With Transthyretin Amyloid Polyneuropathyrecruitingn=15
  • phase1A Study to Compare Two Forms of Study Medicine Tafamidis in the Blood in Healthy Adultscompletedn=22

Patent cliff

source: FDA Orange Book
first barrier falls
Dec 19, 2026
70 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (3)

  • Aug 31, 2035compositionUS 9770441
  • Dec 19, 2026compositionUS 721469570d
  • Dec 19, 2026method-of-use (U-2524)US 721469670d

FDA exclusivities (1)

  • May 3, 2026ODE-237Orphan Drug (7y)

News(10)

  • ESC ‘26: Cytokinetics’ sell-off, Arrowhead’s edge and a heart drug autopsy
    At a big meeting for cardiovascular medicines, Cytokinetics and Arrowhead aimed to separate their drugs from competitors while a failed study pressured Alnylam.
    biopharma_dive · 1mo ago
  • ESC: Alnylam's next-gen silencer sees silver linings after fallout of AZ, Ionis trial in ATTR-CM
    As AstraZeneca appears to close the book on a combo approach following the phase 3 failure of its Ionis-partnered Wainua, several analysts contend it’s too early to count out Alnylam’s silencing dr…
    fiercebiotech · 1mo ago
  • ‘Worse than expected’ Wainua data muddies water for TTR silencers
    AstraZeneca and Ionis Pharmaceuticals’ data drop divulging more details from its highly watched Phase 3 transthyretin silencer trial “further confuses the picture” for Wainua when combined with the…
    biospace · 1mo ago
  • AstraZeneca, Ionis data spark debate about RNA drugs’ impact on deadly heart disease
    Results published in NEJM raised questions about the benefits “silencer” medications provide on top of standard therapies for TTR cardiomyopathy and amplified investor pressure on Alnylam.
    biopharma_dive · 1mo ago
  • BridgeBio continues ATTR ascent as Alnylam’s Amvuttra falls short of expectations
    BridgeBio Pharma’s transthyretin amyloidosis medicine Attruby is off to a strong launch, while Alnylam lowered full-year sales guidance for competitor Amvuttra.
    biospace · 1mo ago
  • Earnings roundup: Gilead’s ‘uncertain’ future, Pfizer’s crossroads and Merck’s PCSK9 launch
    Some analysts see warning signs in crucial drug launches from Gilead and Merck, while an important trial readout could change Pfizer’s growth trajectory.
    biopharma_dive · 2mo ago
  • Pfizer expands multibillion-dollar cost-cutting plan
    Hatched three years ago, the restructuring is now expected to deliver $1 billion in new cost reductions and save Pfizer another $1.5 billion by streamlining drug production.
    biopharma_dive · 2mo ago
  • 5 companies advancing ATTR assets in the wake of Wainua’s fail
    The Phase 3 failure of AstraZeneca and Ionis Pharmaceuticals’ antisense therapy in transthyretin amyloid cardiomyopathy last month left the space reeling—and readjusting. BioSpace looks at five con…
    biospace · 2mo ago
  • Alnylam plunges as earnings deliver ‘one-two punch’
    The RNA-focused biotech shed 30% of its market value — or close to $12 billion — amid growing investor concerns about its main drug business.
    biopharma_dive · 2mo ago
  • Biotechs bring big launches and pharma rivalries into Q2 earnings period
    With the second quarter earnings period underway, BioSpace examines five biotechs with meaningful catalysts that analysts and investors are watching.
    biospace · 2mo ago
view all news mentions →
brand
Vyndamax
generic
tafamidis
indication
Familial Amyloid Cardiomyopathy
phase
marketed
Data sources
ClinicalTrials.gov
last refreshed 40m ago
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