drug · small molecule
ibrutinib
Marketedupdated 5mo agoby $ABBV AbbVie Inc.🔗 ChEMBL
Approvedannual revenue · 2024–2024peak $3.5B
community read0 votes
🐶 often sniffed alongside
top 2Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 40 investigational indications.
targets
Tyrosine-protein kinase BTK
all catalysts(0)
nothing on the calendar yet
Trials studying ibrutinib
- phase3A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)
- phase3A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
- phase3A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis
- —Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia
- phase3Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
- phase2Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
- phase3A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
- phase3Investigation of a Remibrutinib- and Omalizumab-based Treatment Algorithm in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Within 24 Weeks
Patent cliff
source: FDA Orange Bookfirst barrier falls
Dec 28, 2026
90 days
Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.
patents (448)
- Jun 14, 2039formulationUS 12201690
- Sep 3, 2036patentUS 10010507*PED
- Sep 3, 2036patentUS 10010507*PED
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- Sep 3, 2036patentUS 9655857*PED
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- Apr 6, 2036formulationUS 12364698
- Mar 3, 2036formulationUS 10010507
- Mar 3, 2036formulationUS 10010507
- Mar 3, 2036formulationUS 10010507
- Mar 3, 2036formulationUS 10010507
- Mar 3, 2036formulationUS 10213386
- Mar 3, 2036formulationUS 10213386
- Mar 3, 2036formulationUS 10213386
- Mar 3, 2036formulationUS 10213386
- Mar 3, 2036formulationUS 10828259
- Mar 3, 2036formulationUS 10828259
- Mar 3, 2036formulationUS 10828259
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- Mar 3, 2036formulationUS 12551448
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- Mar 3, 2036formulationUS 9655857
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- Apr 24, 2035patentUS 10463668*PED
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- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2654)US 10463668
- Oct 24, 2034method-of-use (U-2970)US 10463668
- Oct 24, 2034method-of-use (U-2846)US 10695350
- Oct 24, 2034method-of-use (U-2970)US 10695350
- Oct 24, 2034method-of-use (U-2846)US 10695350
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- Oct 24, 2034method-of-use (U-2846)US 10695350
- Oct 24, 2034method-of-use (U-2969)US 9795604
- Oct 24, 2034method-of-use (U-2969)US 9795604
- Oct 24, 2034method-of-use (U-2970)US 9795604
- Oct 24, 2034method-of-use (U-2970)US 9795604
- Oct 24, 2034method-of-use (U-2970)US 9795604
- Oct 24, 2034method-of-use (U-2969)US 9795604
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- Apr 30, 2034patentUS 9296753*PED
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- Oct 30, 2033compositionUS 9296753
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- Aug 18, 2033method-of-use (U-1650)US 9540382
- Aug 18, 2033method-of-use (U-1684)US 9540382
- Jun 3, 2033compositionUS 10106548
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- Dec 3, 2031patentUS 10004746*PED
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- Jun 3, 2031method-of-use (U-2241)US 100047464.7y
- Jun 3, 2031method-of-use (U-3847)US 100047464.7y
- Jun 3, 2031method-of-use (U-2242)US 100047464.7y
- Jun 3, 2031method-of-use (U-2242)US 100047464.7y
- Jun 3, 2031method-of-use (U-1684)US 100047464.7y
- Jun 3, 2031method-of-use (U-1946)US 100047464.7y
- Jun 3, 2031method-of-use (U-2241)US 100047464.7y
- Jun 3, 2031method-of-use (U-1650)US 100164354.7y
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- Jun 3, 2031method-of-use (U-1650)US 100164354.7y
- Jun 3, 2031method-of-use (U-1650)US 100164354.7y
- Jun 3, 2031method-of-use (U-3845)US 100164354.7y
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- Jun 3, 2031method-of-use (U-3422)US 104784394.7y
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- Jun 3, 2031method-of-use (U-1946)US 116728034.7y
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- Jun 3, 2031method-of-use (U-3843)US 116728034.7y
- Jun 3, 2031method-of-use (U-1456)US 87540904.7y
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- Jun 3, 2031method-of-use (U-2242)US 89999994.7y
- Jun 3, 2031method-of-use (U-1683)US 89999994.7y
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- Jun 3, 2031method-of-use (U-2159)US 98018834.7y
- Jun 3, 2031method-of-use (U-1947)US 98147214.7y
- May 13, 2028patentUS 8008309*PED1.6y
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- Nov 13, 2027compositionUS 80083091.1y
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- Dec 28, 2026compositionUS 869771190d
- Dec 28, 2026compositionUS 869771190d
- Dec 28, 2026compositionUS 869771190d
- Dec 28, 2026compositionUS 869771190d
- Dec 28, 2026method-of-use (U-3842)US 870378090d
- Dec 28, 2026method-of-use (U-2242)US 870378090d
- Dec 28, 2026method-of-use (U-2242)US 870378090d
- Dec 28, 2026method-of-use (U-1491)US 870378090d
- Dec 28, 2026method-of-use (U-1491)US 870378090d
- Dec 28, 2026method-of-use (U-2242)US 870378090d
- Dec 28, 2026method-of-use (U-1491)US 870378090d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026compositionUS 873540390d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026formulationUS 875409190d
- Dec 28, 2026method-of-use (U-1946)US 895201590d
- Dec 28, 2026method-of-use (U-2241)US 895201590d
- Dec 28, 2026method-of-use (U-1491)US 895201590d
- Dec 28, 2026method-of-use (U-1946)US 895201590d
- Dec 28, 2026method-of-use (U-1491)US 895201590d
- Dec 28, 2026method-of-use (U-3845)US 895201590d
- Dec 28, 2026method-of-use (U-1946)US 895201590d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 895707990d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
- Dec 28, 2026compositionUS 918125790d
FDA exclusivities (28)
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Feb 24, 2030PEDPediatric (6mo bonus)3.4y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Feb 24, 2026PEDPediatric (6mo bonus)
- Aug 24, 2025NPPNew Product (3y)
- Aug 24, 2025NPNP
- Aug 24, 2025NPPNew Product (3y)
- Aug 24, 2025NPPNew Product (3y)
- Aug 24, 2025NPPNew Product (3y)
- Aug 24, 2025NPPNew Product (3y)
- Aug 24, 2025NPPNew Product (3y)
News(3)
- J&J dips despite upbeat outlook; AstraZeneca, Spero cut China dealsJ&J’s shares ticked down as oncology sales missed expectations. Elsewhere, AstraZeneca bet $600 million on a lung cancer drug and a pair of biotechs snagged two of the year’s top venture rounds.biopharma_dive · 2mo ago
- Ibrutinib Monotherapy Yields Decade-Long Durable Efficacy in Across CLL SubtypesIbrutinib monotherapy produced durable efficacy over 10 years in patients with or without TP53-mutated chronic lymphocytic leukemia.onclive · 4mo ago
- Retrospective Data Show Potential Real-World TTNT and OS Improvements With Next-Generation BTK Inhibitors in R/R MCLRetrospective data showed zanubrutinib was associated with improved real-world overall survival vs ibrutinib in second- or third-line mantle cell lymphoma.onclive · 4mo ago
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