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  1. pharmadog
  2. ›drugs
  3. ›Imbruvica
drug · small molecule
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ibrutinib

Marketedupdated 5mo ago
by $ABBV AbbVie Inc.🔗 ChEMBL
Approved
annual revenue · 2024–2024peak $3.5B
2024: $3.5B2024$3.5B
community read0 votes

🐶 often sniffed alongside

top 2
  • tagApproval240 co-mentions · 60 sources
  • tagSmall Molecule120 co-mentions · 60 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 40 investigational indications.

targets

Tyrosine-protein kinase BTK

all catalysts(0)

nothing on the calendar yet

Trials studying ibrutinib

  • phase3A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)recruitingn=180
  • phase3A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)active not recruitingn=211
  • phase3A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravisactive not recruitingn=180
  • —Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemiarecruitingn=180
  • phase3Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)active not recruitingn=500
  • phase2Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphomaactive not recruitingn=129
  • phase3A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)recruitingn=1,200
  • phase3Investigation of a Remibrutinib- and Omalizumab-based Treatment Algorithm in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Within 24 Weeksnot yet recruitingn=382

Patent cliff

source: FDA Orange Book
first barrier falls
Dec 28, 2026
90 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (448)

  • Jun 14, 2039formulationUS 12201690
  • Sep 3, 2036patentUS 10010507*PED
  • Sep 3, 2036patentUS 10010507*PED
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  • Sep 3, 2036patentUS 10213386*PED
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  • Sep 3, 2036patentUS 10828259*PED
  • Sep 3, 2036patentUS 10828259*PED
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  • Sep 3, 2036patentUS 9655857*PED
  • Sep 3, 2036patentUS 9655857*PED
  • Sep 3, 2036patentUS 9655857*PED
  • Sep 3, 2036patentUS 9655857*PED
  • Apr 6, 2036formulationUS 12364698
  • Mar 3, 2036formulationUS 10010507
  • Mar 3, 2036formulationUS 10010507
  • Mar 3, 2036formulationUS 10010507
  • Mar 3, 2036formulationUS 10010507
  • Mar 3, 2036formulationUS 10213386
  • Mar 3, 2036formulationUS 10213386
  • Mar 3, 2036formulationUS 10213386
  • Mar 3, 2036formulationUS 10213386
  • Mar 3, 2036formulationUS 10828259
  • Mar 3, 2036formulationUS 10828259
  • Mar 3, 2036formulationUS 10828259
  • Mar 3, 2036formulationUS 10828259
  • Mar 3, 2036formulationUS 12551448
  • Mar 3, 2036formulationUS 12551448
  • Mar 3, 2036formulationUS 12551448
  • Mar 3, 2036formulationUS 9655857
  • Mar 3, 2036formulationUS 9655857
  • Mar 3, 2036formulationUS 9655857
  • Mar 3, 2036formulationUS 9655857
  • Apr 24, 2035patentUS 10463668*PED
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  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2654)US 10463668
  • Oct 24, 2034method-of-use (U-2970)US 10463668
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2970)US 10695350
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2846)US 10695350
  • Oct 24, 2034method-of-use (U-2969)US 9795604
  • Oct 24, 2034method-of-use (U-2969)US 9795604
  • Oct 24, 2034method-of-use (U-2970)US 9795604
  • Oct 24, 2034method-of-use (U-2970)US 9795604
  • Oct 24, 2034method-of-use (U-2970)US 9795604
  • Oct 24, 2034method-of-use (U-2969)US 9795604
  • Oct 24, 2034method-of-use (U-2969)US 9795604
  • Apr 30, 2034patentUS 9296753*PED
  • Apr 30, 2034patentUS 9296753*PED
  • Apr 30, 2034patentUS 9296753*PED
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  • Feb 18, 2034patentUS 9540382*PED
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  • Dec 3, 2033patentUS 10106548*PED
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  • Dec 3, 2033patentUS 10125140*PED
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  • Dec 3, 2033patentUS 10294231*PED
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  • Dec 3, 2033patentUS 10294232*PED
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  • Dec 3, 2033patentUS 10752634*PED
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  • Dec 3, 2033patentUS 10961251*PED
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  • Dec 3, 2033patentUS 9713617*PED
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  • Dec 3, 2033patentUS 9725455*PED
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  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Oct 30, 2033compositionUS 9296753
  • Aug 18, 2033method-of-use (U-1650)US 9540382
  • Aug 18, 2033method-of-use (U-1684)US 9540382
  • Jun 3, 2033compositionUS 10106548
  • Jun 3, 2033compositionUS 10106548
  • Jun 3, 2033compositionUS 10106548
  • Jun 3, 2033compositionUS 10106548
  • Jun 3, 2033compositionUS 10106548
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  • Jun 3, 2033compositionUS 10125140
  • Jun 3, 2033compositionUS 10125140
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  • Jun 3, 2033compositionUS 10125140
  • Jun 3, 2033formulationUS 10294231
  • Jun 3, 2033formulationUS 10294231
  • Jun 3, 2033formulationUS 10294232
  • Jun 3, 2033formulationUS 10294232
  • Jun 3, 2033formulationUS 10752634
  • Jun 3, 2033formulationUS 10752634
  • Jun 3, 2033formulationUS 10961251
  • Jun 3, 2033formulationUS 10961251
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  • Jun 3, 2033formulationUS 9713617
  • Jun 3, 2033formulationUS 9713617
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Jun 3, 2033compositionUS 9725455
  • Dec 3, 2031patentUS 10004746*PED
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  • Dec 3, 2031patentUS 10016435*PED
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  • Dec 3, 2031patentUS 9814721*PED
  • Jun 3, 2031method-of-use (U-2241)US 100047464.7y
  • Jun 3, 2031method-of-use (U-3847)US 100047464.7y
  • Jun 3, 2031method-of-use (U-2242)US 100047464.7y
  • Jun 3, 2031method-of-use (U-2242)US 100047464.7y
  • Jun 3, 2031method-of-use (U-1684)US 100047464.7y
  • Jun 3, 2031method-of-use (U-1946)US 100047464.7y
  • Jun 3, 2031method-of-use (U-2241)US 100047464.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-3845)US 100164354.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-1650)US 100164354.7y
  • Jun 3, 2031method-of-use (U-3422)US 104784394.7y
  • Jun 3, 2031method-of-use (U-3845)US 104784394.7y
  • Jun 3, 2031method-of-use (U-3422)US 104784394.7y
  • Jun 3, 2031method-of-use (U-3422)US 104784394.7y
  • Jun 3, 2031method-of-use (U-3422)US 104784394.7y
  • Jun 3, 2031method-of-use (U-1684)US 104784394.7y
  • Jun 3, 2031method-of-use (U-3422)US 104784394.7y
  • Jun 3, 2031method-of-use (U-1456)US 106536964.7y
  • Jun 3, 2031method-of-use (U-2943)US 107513424.7y
  • Jun 3, 2031method-of-use (U-1491)US 107513424.7y
  • Jun 3, 2031method-of-use (U-2943)US 107513424.7y
  • Jun 3, 2031method-of-use (U-2943)US 107513424.7y
  • Jun 3, 2031method-of-use (U-2943)US 107513424.7y
  • Jun 3, 2031method-of-use (U-1491)US 107513424.7y
  • Jun 3, 2031method-of-use (U-3842)US 107513424.7y
  • Jun 3, 2031method-of-use (U-2242)US 116728034.7y
  • Jun 3, 2031method-of-use (U-1946)US 116728034.7y
  • Jun 3, 2031method-of-use (U-2242)US 116728034.7y
  • Jun 3, 2031method-of-use (U-1684)US 116728034.7y
  • Jun 3, 2031method-of-use (U-2242)US 116728034.7y
  • Jun 3, 2031method-of-use (U-3843)US 116728034.7y
  • Jun 3, 2031method-of-use (U-1456)US 87540904.7y
  • Jun 3, 2031method-of-use (U-1491)US 89999994.7y
  • Jun 3, 2031method-of-use (U-1946)US 89999994.7y
  • Jun 3, 2031method-of-use (U-1946)US 89999994.7y
  • Jun 3, 2031method-of-use (U-3844)US 89999994.7y
  • Jun 3, 2031method-of-use (U-1946)US 89999994.7y
  • Jun 3, 2031method-of-use (U-2242)US 89999994.7y
  • Jun 3, 2031method-of-use (U-1683)US 89999994.7y
  • Jun 3, 2031method-of-use (U-1650)US 91258894.7y
  • Jun 3, 2031method-of-use (U-3845)US 91258894.7y
  • Jun 3, 2031method-of-use (U-1745)US 91258894.7y
  • Jun 3, 2031method-of-use (U-1650)US 91258894.7y
  • Jun 3, 2031method-of-use (U-1650)US 91258894.7y
  • Jun 3, 2031method-of-use (U-1650)US 91258894.7y
  • Jun 3, 2031method-of-use (U-1650)US 91258894.7y
  • Jun 3, 2031method-of-use (U-3847)US 98018814.7y
  • Jun 3, 2031method-of-use (U-2242)US 98018814.7y
  • Jun 3, 2031method-of-use (U-2242)US 98018814.7y
  • Jun 3, 2031method-of-use (U-1491)US 98018814.7y
  • Jun 3, 2031method-of-use (U-2242)US 98018814.7y
  • Jun 3, 2031method-of-use (U-1491)US 98018814.7y
  • Jun 3, 2031method-of-use (U-1491)US 98018814.7y
  • Jun 3, 2031method-of-use (U-2243)US 98018834.7y
  • Jun 3, 2031method-of-use (U-2159)US 98018834.7y
  • Jun 3, 2031method-of-use (U-2159)US 98018834.7y
  • Jun 3, 2031method-of-use (U-2159)US 98018834.7y
  • Jun 3, 2031method-of-use (U-3844)US 98018834.7y
  • Jun 3, 2031method-of-use (U-2243)US 98018834.7y
  • Jun 3, 2031method-of-use (U-2159)US 98018834.7y
  • Jun 3, 2031method-of-use (U-1947)US 98147214.7y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • May 13, 2028patentUS 8008309*PED1.6y
  • Nov 13, 2027compositionUS 80083091.1y
  • Nov 13, 2027compositionUS 80083091.1y
  • Nov 13, 2027compositionUS 80083091.1y
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  • Oct 26, 2027patentUS 8563563*PED1.1y
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  • Jun 28, 2027patentUS 7514444*PED272d
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  • Jun 28, 2027patentUS 8952015*PED272d
  • Jun 28, 2027patentUS 8952015*PED272d
  • Jun 28, 2027patentUS 8952015*PED272d
  • Jun 28, 2027patentUS 8952015*PED272d
  • Jun 28, 2027patentUS 8957079*PED272d
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  • Jun 28, 2027patentUS 8957079*PED272d
  • Jun 28, 2027patentUS 8957079*PED272d
  • Jun 28, 2027patentUS 8957079*PED272d
  • Jun 28, 2027patentUS 8957079*PED272d
  • Jun 28, 2027patentUS 8957079*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Jun 28, 2027patentUS 9181257*PED272d
  • Apr 26, 2027method-of-use (U-1491)US 8563563209d
  • Apr 26, 2027method-of-use (U-1491)US 8563563209d
  • Apr 26, 2027method-of-use (U-2241)US 8563563209d
  • Apr 26, 2027method-of-use (U-3845)US 8563563209d
  • Apr 26, 2027method-of-use (U-1491)US 8563563209d
  • Apr 26, 2027method-of-use (U-2242)US 8563563209d
  • Apr 26, 2027method-of-use (U-1491)US 8563563209d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026compositionUS 751444490d
  • Dec 28, 2026method-of-use (U-1650)US 847628490d
  • Dec 28, 2026method-of-use (U-3845)US 847628490d
  • Dec 28, 2026method-of-use (U-1946)US 847628490d
  • Dec 28, 2026method-of-use (U-2241)US 847628490d
  • Dec 28, 2026method-of-use (U-2241)US 847628490d
  • Dec 28, 2026method-of-use (U-1946)US 847628490d
  • Dec 28, 2026method-of-use (U-1650)US 847628490d
  • Dec 28, 2026method-of-use (U-1650)US 849727790d
  • Dec 28, 2026method-of-use (U-2242)US 849727790d
  • Dec 28, 2026method-of-use (U-3422)US 849727790d
  • Dec 28, 2026method-of-use (U-2970)US 849727790d
  • Dec 28, 2026method-of-use (U-1491)US 849727790d
  • Dec 28, 2026method-of-use (U-3422)US 849727790d
  • Dec 28, 2026method-of-use (U-1456)US 849727790d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026compositionUS 869771190d
  • Dec 28, 2026method-of-use (U-3842)US 870378090d
  • Dec 28, 2026method-of-use (U-2242)US 870378090d
  • Dec 28, 2026method-of-use (U-2242)US 870378090d
  • Dec 28, 2026method-of-use (U-1491)US 870378090d
  • Dec 28, 2026method-of-use (U-1491)US 870378090d
  • Dec 28, 2026method-of-use (U-2242)US 870378090d
  • Dec 28, 2026method-of-use (U-1491)US 870378090d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026compositionUS 873540390d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026formulationUS 875409190d
  • Dec 28, 2026method-of-use (U-1946)US 895201590d
  • Dec 28, 2026method-of-use (U-2241)US 895201590d
  • Dec 28, 2026method-of-use (U-1491)US 895201590d
  • Dec 28, 2026method-of-use (U-1946)US 895201590d
  • Dec 28, 2026method-of-use (U-1491)US 895201590d
  • Dec 28, 2026method-of-use (U-3845)US 895201590d
  • Dec 28, 2026method-of-use (U-1946)US 895201590d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 895707990d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d
  • Dec 28, 2026compositionUS 918125790d

FDA exclusivities (28)

  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Feb 24, 2030PEDPediatric (6mo bonus)3.4y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Aug 24, 2029ODE-405Orphan Drug (7y)2.9y
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Feb 24, 2026PEDPediatric (6mo bonus)
  • Aug 24, 2025NPPNew Product (3y)
  • Aug 24, 2025NPNP
  • Aug 24, 2025NPPNew Product (3y)
  • Aug 24, 2025NPPNew Product (3y)
  • Aug 24, 2025NPPNew Product (3y)
  • Aug 24, 2025NPPNew Product (3y)
  • Aug 24, 2025NPPNew Product (3y)

News(3)

  • J&J dips despite upbeat outlook; AstraZeneca, Spero cut China deals
    J&J’s shares ticked down as oncology sales missed expectations. Elsewhere, AstraZeneca bet $600 million on a lung cancer drug and a pair of biotechs snagged two of the year’s top venture rounds.
    biopharma_dive · 2mo ago
  • Ibrutinib Monotherapy Yields Decade-Long Durable Efficacy in Across CLL Subtypes
    Ibrutinib monotherapy produced durable efficacy over 10 years in patients with or without TP53-mutated chronic lymphocytic leukemia.
    onclive · 4mo ago
  • Retrospective Data Show Potential Real-World TTNT and OS Improvements With Next-Generation BTK Inhibitors in R/R MCL
    Retrospective data showed zanubrutinib was associated with improved real-world overall survival vs ibrutinib in second- or third-line mantle cell lymphoma.
    onclive · 4mo ago
brand
Imbruvica
trade names
Imbruvica
generic
ibrutinib
MOA
Tyrosine-protein kinase BTK inhibitor
indication
Follicular Lymphoma
phase
marketed
approved
2013-11-13
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 7m ago
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