the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Oct 23, 202638dpatentAdasuveloxapineAlexza Pharmaceuticals Inc
- Oct 23, 202638dODE-277Zejulaniraparib$JNJJOHNSON & JOHNSON
- Oct 24, 202639dI-924TibsovoivosidenibLes Laboratoires Servier SAS
- Oct 25, 202640dpatentSyfovrepegcetacoplan$APLSApellis Pharmaceuticals, Inc.
- Oct 26, 202641dpatentGenvoya(cobicistat + elvitegravir + emtricitabine + tenofovir alafenamide fumarate)$GILDGILEAD SCIENCES, INC.
- Oct 26, 202641dpatentStribild(cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Oct 26, 202641dpatentomacetaxine mepesuccinate$TEVATEVA PHARMACEUTICAL INDUSTRIES LTD
- Oct 29, 202644dI-953Scemblixasciminib hydrochloride$NVSNOVARTIS AG
- Oct 29, 202644dM-14Kalydecoivacaftor$VERXVertex, Inc.
- Oct 30, 202645dI-967Mavyret(glecaprevir + pibrentasvir)$ABBVAbbVie Inc.
- Oct 31, 202646dpatentSELEXIPAGSELEXIPAG$JNJJOHNSON & JOHNSON
- Nov 1, 202647dGAINVoqueznavonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- Nov 2, 202648dpatentPREGABALINPREGABALINRK Pharma Inc
- Nov 8, 202654dpatentOrkambi(ivacaftor + lumacaftor)$VERXVertex, Inc.
- Nov 8, 202654dpatentSacubitril + Valsartan(sacubitril + valsartan)Novugen Pharma (Malaysia) Sdn Bhd
- Nov 8, 202654dpatentSACUBITRIL AND VALSARTANSACUBITRILSomerset Therapeutics LLC
- Nov 8, 202654dI-958ZEPBOUNDTIRZEPATIDE$LLYELI LILLY & Co
- Nov 8, 202654dNPPFarxigadapagliflozin propanediol$AZNASTRAZENECA PLC
- Nov 9, 202655dpatentGilotrifafatinib dimaleateBoehringer Ingelheim Corp
- Nov 9, 202655dpatentTarpeyobudesonideCalliditas Therapeutics AB
- Nov 9, 202655dI-929ExparelbupivacaineAllay Therapeutics Inc
- Nov 10, 202656dpatentHorizantgabapentin enacarbilAzurity Pharmaceuticals Inc
- Nov 11, 202657dpatentIzervayavacincaptad pegol sodiumAstellas Pharma US Inc
- Nov 12, 202658dpatentEmblaveo(avibactam sodium + aztreonam)$ABBVAbbVie Inc.
- Nov 12, 202658dpatentAvycaz(avibactam sodium + ceftazidime)$ABBVAbbVie Inc.
- Nov 13, 202659dPEDBreo Ellipta(fluticasone furoate + vilanterol trifenatate)GlaxoSmithKline LLC
- Nov 13, 202659dpatentSofdrasofpironium bromideBotanix Pharmaceuticals Ltd
- Nov 14, 202660dI-936Brukinsazanubrutinib$ONCBeOne Medicines Ltd.
- Nov 15, 202661dpatentHernexeoszongertinibBoehringer Ingelheim Corp
- Nov 17, 202663dI-926XtandienzalutamideAlessa Therapeutics Inc
- Nov 20, 202666dODE-273Givlaarigivosiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Nov 21, 202667dI-960CALQUENCEACALABRUTINIB$AZNASTRAZENECA PLC
- Nov 21, 202667dpatentEliquisapixabanBristol-Myers Squibb Co
- Nov 22, 202668dpatentSUMATRIPTAN SUCCINATESUMATRIPTAN SUCCINATEAllergan USA Inc
- Nov 23, 202669dNCELivtencitymaribavirTakeda Pharmaceuticals USA Inc
- Nov 24, 202670dpatentSteglujan(ertugliflozin + sitagliptin phosphate)Merck Sharp & Dohme (IA) LLC
- Nov 24, 202670dpatentJanumet XR(metformin hydrochloride + sitagliptin phosphate)Merck Sharp & Dohme LLC
- Nov 24, 202670dNPPOpzeluraruxolitinib phosphate$INCYINCYTE CORP
- Nov 24, 202670dpatentSITAGLIPTIN PHOSPHATESITAGLIPTIN PHOSPHATEMerck Sharp & Dohme LLC
- Nov 24, 202670dpatentMetformin Hydrochloridemetformin hydrochlorideIntellipharmaceutics Ltd
- Nov 26, 202672dpatentLURASIDONE HYDROCHLORIDELURASIDONE HYDROCHLORIDESumitomo Pharma America Inc
- Nov 28, 202674dpatentZtalmyganaxoloneMarinus Pharmaceuticals Inc
- Nov 28, 202674dpatentRopivacaine Hydrochlorideropivacaine [INN]$PRFXPRF Technologies Ltd.
- Nov 29, 202675dpatentNasonex 24 HR Allergymometasone furoateL. Perrigo Company
- Dec 1, 202677dpatentSirturobedaquiline fumarateJanssen Therapeutics
- Dec 1, 202677dpatentZunveylbenzgalantamineAlphaCognition Inc
- Dec 2, 202678dpatentCLEOCINCLINDAMYCIN PHOSPHATE$PFEPFIZER INC
- Dec 4, 202680dpatentAdempasriociguatBayer HealthCare Pharmaceuticals Inc
- Dec 5, 202681dpatentArikayceamikacin sulfate$INSMINSMED Inc
- Dec 5, 202681dpatentRasagiline Mesylaterasagiline mesylateCarnegie Pharmaceuticals LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)