the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Aug 14, 202638dpatentCometriqcabozantinib s-malate$EXELEXELIXIS, INC.
- Aug 14, 202638dpatentMalathionSuven Life Sciences Ltd
- Aug 14, 202638dNPMelblezmelphalan hydrochloride$DCTHDELCATH SYSTEMS, INC.
- Aug 14, 202638dNPPWakixpitolisant hydrochloride$HRMYHarmony Biosciences Holdings, Inc.
- Aug 14, 202638dGAINPretomanidpretomanidMylan Specialty LP
- Aug 15, 202639dNPRozlytrekentrectinibF. Hoffmann-La Roche Ltd
- Aug 16, 202640dpatentGLYCOPYRROLATEGLYCOPYRROLATEExela Pharma Sciences LLC
- Aug 16, 202640dODE-259InrebicfedratinibBristol-Myers Squibb Co
- Aug 18, 202642dI-925VALBENAZINE TOSYLATEVALBENAZINE TOSYLATE$NBIXNEUROCRINE BIOSCIENCES INC
- Aug 18, 202642dpatentFarxigadapagliflozin propanediol$AZNASTRAZENECA PLC
- Aug 18, 202642dpatentOrserduelacestrant hydrochlorideA. Menarini Industrie Farmaceutiche Riunite Srl
- Aug 22, 202646dODE-260Tybostcobicistat$GILDGILEAD SCIENCES, INC.
- Aug 22, 202646dpatentIvabradine Hydrochlorideivabradine hydrochlorideIngenus Pharmaceuticals LLC
- Aug 23, 202647dNCEKorsuvadifelikefalinVifor Pharma Inc
- Aug 23, 202647dpatentIsturisaosilodrostat phosphateRecordati Rare Diseases Inc
- Aug 23, 202647dM-232Trintellixvortioxetine hydrobromideTakeda Pharmaceuticals USA Inc
- Aug 24, 202648dpatentDymista(azelastine hydrochloride + fluticasone propionate)Mylan Pharmaceuticals Inc
- Aug 24, 202648dpatentXtandienzalutamideAlessa Therapeutics Inc
- Aug 24, 202648dpatentNuplazidpimavanserin tartrate$ACADACADIA PHARMACEUTICALS INC
- Aug 26, 202650dpatentFluticasone Propionatefluticasone propionateGlenmark Pharmaceuticals Ltd
- Aug 27, 202651dpatentGenvoya(cobicistat + elvitegravir + emtricitabine + tenofovir alafenamide fumarate)$GILDGILEAD SCIENCES, INC.
- Aug 27, 202651dpatentStribild(cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Aug 28, 202652dODE*Harvoni(ledipasvir + sofosbuvir)$GILDGILEAD SCIENCES, INC.
- Aug 28, 202652dpatentNexplanonetonogestrel$DAREDare Bioscience, Inc.
- Aug 28, 202652dODE*Sovaldisofosbuvir$GILDGILEAD SCIENCES, INC.
- Aug 29, 202653dpatentNebivolol Hydrochloridenebivolol hydrochlorideBeximco Pharmaceuticals USA Inc
- Aug 30, 202654dODE-296POMALIDOMIDEPOMALIDOMIDECelgene Corp
- Aug 30, 202654dpatentLinzesslinaclotide$ABBVAbbVie Inc.
- Sep 1, 202656dpatentTOLVAPTANTOLVAPTANOtsuka America Pharmaceutical Inc
- Sep 9, 202664dpatentRyteloimetelstat sodium$GERNGERON CORP
- Sep 11, 202666dpatentOpsynvi(macitentan + tadalafil)Janssen Biotech Inc
- Sep 11, 202666dpatentMACITENTANMACITENTAN$JNJJOHNSON & JOHNSON
- Sep 12, 202667dpatentRezdiffraresmetirom$MDGLMADRIGAL PHARMACEUTICALS, INC.
- Sep 12, 202667dpatentTeriflunomideteriflunomideSOLA Pharmaceuticals Inc
- Sep 15, 202670dpatentAdapaleneadapalenePL Developments Copiague LLC
- Sep 15, 202670dpatentLynkuetelinzanetantBayer USA LLC
- Sep 16, 202671dCGTCITALOPRAM HYDROBROMIDECITALOPRAM HYDROBROMIDEInvaGen Pharmaceuticals Inc
- Sep 16, 202671dODE-428Mekinisttrametinib dimethyl sulfoxide$NVSNOVARTIS AG
- Sep 16, 202671dODE-428Tafinlardabrafenib mesylate$NVSNOVARTIS AG
- Sep 19, 202674dpatentLenvimalenvatinib mesylateEisai Co Ltd
- Sep 21, 202676dI-922SYNJARDYEMPAGLIFLOZINBoehringer Ingelheim Corp
- Sep 22, 202677dpatentCINACALCET HYDROCHLORIDECINACALCET HYDROCHLORIDESlate Run Pharmaceuticals LLC
- Sep 22, 202677dpatentPIRFENIDONEPIRFENIDONEAizant Drug Research Solutions Pvt Ltd
- Sep 25, 202680dNPRyzumviphentolamine mesylate$IRDOpus Genetics, Inc.
- Sep 26, 202681dI-923BosutinibbosutinibAlembic Pharmaceuticals Inc
- Sep 26, 202681dpatentRisperidonerisperidoneSenores Pharmaceuticals Inc
- Sep 28, 202683dpatentDASATINIBDASATINIBXspray Pharma AB
- Sep 28, 202683dNCEQuliptaatogepant$ABBVAbbVie Inc.
- Sep 28, 202683dNPOpfoldamiglustatBiocodex
- Sep 29, 202684dI-938Livmarlimaralixibat chloride$MIRMMirum Pharmaceuticals, Inc.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)