the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Sep 18, 20292.9ypatentLapatiniblapatinib ditosylateLupin Ltd
- Sep 19, 20292.9ypatentMILNACIPRAN HYDROCHLORIDEMILNACIPRAN HYDROCHLORIDEMylan Pharmaceuticals Inc
- Sep 20, 20292.9yODE-384Pedmarksodium thiosulfate$REGNREGENERON PHARMACEUTICALS, INC.
- Sep 22, 20292.9ypatentLonsurf(tipiracil hydrochloride + trifluridine)Taiho Oncology Inc
- Sep 24, 20292.9yNCEAqneursalevacetylleucineIntraBio Ltd
- Sep 26, 20292.9yNCECobenfy(trospium chloride + xanomeline tartrate)Bristol-Myers Squibb Co
- Sep 30, 20292.9ypatentMidolibuprofenBionpharma Inc
- Oct 5, 20292.9ypatentAmlodipine Besylateamlodipine besylateChina Resources Saike Pharmaceutical Co Ltd
- Oct 10, 20292.9yNCEItovebiinavolisibF. Hoffmann-La Roche Ltd
- Oct 13, 20293.0ypatentNuzolvencezoliflodacinEntasis Therapeutics Holdings Inc
- Oct 15, 20293.0ypatentVivitrolnaltrexone$AARDAardvark Therapeutics, Inc.
- Oct 21, 20293.0ypatentLarotrectinib Sulfate Bayerlarotrectinib sulfateBayer HealthCare Pharmaceuticals Inc
- Oct 22, 20293.0ypatentLidocaine Hydrochloridelidocaine hydrochlorideInternational Medication Systems Ltd
- Oct 22, 20293.0ypatentAliqopacopanlisib hydrochlorideBayer HealthCare Pharmaceuticals Inc
- Nov 6, 20293.0ypatentOxybutynin Hydrochlorideoxybutynin chlorideKVK-Tech Inc
- Nov 13, 20293.0ypatentBesivancebesifloxacin hydrochloride$BLCOBausch & Lomb Corp
- Nov 14, 20293.0yGAINFetrojacefiderocol sulfate tosylate$SGIOFSHIONOGI & CO LTD
- Nov 15, 20293.0yNCERevuforjrevumenib citrate$SNDXSyndax Pharmaceuticals Inc
- Nov 16, 20293.0ypatentPonvoryponesimod$VNDAVanda Pharmaceuticals Inc.
- Nov 17, 20293.0yODE-414Sezabyphenobarbital sodiumSun Pharmaceutical Industries Ltd
- Nov 20, 20293.1ypatentBelsomrasuvorexant$MRKMerck & Co., Inc.
- Nov 22, 20293.1yNCEAttrubyacoramidis hydrochloride$BBIOBridgeBio Pharma, Inc.
- Nov 23, 20293.1ypatentOndansetronondansetronIpca Pharmaceuticals Inc
- Dec 13, 20293.1yNCECrenessitycrinecerfont$NBIXNEUROCRINE BIOSCIENCES INC
- Dec 16, 20293.1ypatentGiaprezaangiotensin II acetateLa Jolla Pharmaceutical Company
- Dec 22, 20293.1ypatentGimotimetoclopramide hydrochlorideEvoke Pharma Inc
- Dec 30, 20293.2ypatentXphozahtenapanor hydrochloride$ARDXARDELYX, INC.
- Jan 27, 20303.2ypatentRocklatan(latanoprost + netarsudil mesylate)$ALCALCON INC
- Jan 27, 20303.2ypatentRhopressanetarsudil mesylate$ALCALCON INC
- Jan 30, 20303.3yNCEJournavxsuzetrigine$VERXVertex, Inc.
- Feb 8, 20303.3ypatentDrospirenone + Ethinyl Estradiol + Levomefolate Calcium(drospirenone + ethinylestradiol + levomefolate calcium) + levomefolate calciumAllergan Sales LLC
- Feb 8, 20303.3ypatentSlynddrospirenoneExeltis USA Inc
- Feb 10, 20303.3ypatentNithiodote(sodium nitrite + sodium thiosulfate)Hope Biosciences LLC
- Feb 10, 20303.3ypatentSodium Nitritesodium nitriteHope Biosciences LLC
- Feb 11, 20303.3ypatentCETIRIZINE HYDROCHLORIDECETIRIZINE HYDROCHLORIDEPL Developments Copiague LLC
- Feb 11, 20303.3yNCEGomeklimirdametinibSpringWorks Therapeutics Inc
- Feb 12, 20303.3ypatentALVIMOPANALVIMOPANPar Pharmaceutical Inc
- Feb 14, 20303.3yNCERomvimzavimseltinibOno Pharmaceutical Co Ltd
- Feb 24, 20303.3ypatentTAZAROTENETAZAROTENE$GRIGRI Bio, Inc.
- Mar 11, 20303.4ypatentIDELALISIBIDELALISIB$GILDGILEAD SCIENCES, INC.
- Mar 19, 20303.4ypatentXyostedtestosterone enanthateAntares Pharma Inc
- Mar 24, 20303.4ypatentOtovel(ciprofloxacin hydrochloride + fluocinolone acetonide)SALVAT USA Inc
- Mar 28, 20303.4yNCEQfitliafitusiran [INN]Genzyme Corp
- Apr 2, 20303.4ypatentKovanaze(oxymetazoline hydrochloride + tetracaine hydrochloride)St Renatus LLC
- Apr 7, 20303.4ypatentTOLVAPTANTOLVAPTANOtsuka America Pharmaceutical Inc
- Apr 9, 20303.4ypatentBRIVARACETAMBRIVARACETAMUCB SA
- Apr 17, 20303.5ypatentTICAGRELORTICAGRELORHisun Pharmaceutical USA Inc
- Apr 19, 20303.5ypatentCelecoxib GreenstonecelecoxibGreenstone LLC
- Apr 23, 20303.5ypatentLicartdiclofenacIBSA Pharma Inc
- Apr 23, 20303.5ypatentIndomethacinindomethacinACP Nimble Buyer Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)