the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Apr 28, 20292.8ypatentEfavirenzefavirenzCamber Pharmaceuticals Inc
- Apr 28, 20292.8yODE-401Cuvriortrientine tetrahydrochlorideOrphalan SA
- May 12, 20292.8yODE-144Radicava ORSedaravone$SGIOFSHIONOGI & CO LTD
- May 13, 20292.8ypatentKengrealcangrelorChiesi USA Inc
- May 20, 20292.9ypatentBupivacaine Hydrochloridebupivacaine hydrochlorideOncoZenge AB
- May 21, 20292.9ypatentDdavpdesmopressin acetateFerring Pharmaceuticals Inc
- May 28, 20292.9ypatentZioptantafluprostThea Pharma Inc
- May 29, 20292.9ypatentMOXIFLOXACIN HYDROCHLORIDEMOXIFLOXACIN HYDROCHLORIDEAlvogen Inc
- Jun 3, 20292.9ypatentOrlynvah(probenecid [INN] + sulopenem etzadroxil)$ITRMFIterum Therapeutics plc
- Jun 10, 20292.9yNCEIqirvoelafibranorIpsen SA
- Jun 26, 20293.0ypatentMiplyffaarimoclomol citrate$ZVRAZEVRA THERAPEUTICS, INC.
- Jun 26, 20293.0yNCEOhtuvayreensifentrineVerona Pharma Ltd
- Jun 30, 20293.0ypatentTriptodurtriptorelin pamoateAzurity Pharmaceuticals Inc
- Jul 6, 20293.0ypatentOrilissaelagolix sodium$ABBVAbbVie Inc.
- Jul 8, 20293.0ypatentValchlormechlorethamine hydrochlorideHelsinn Therapeutics (US) Inc
- Jul 14, 20293.0yODE-403DiacomitstiripentolBiocodex
- Jul 24, 20293.0ypatentOdomzosonidegib phosphateSun Pharmaceutical Industries Ltd
- Jul 25, 20293.0yNCELeqselvideuruxolitinib phosphateSun Pharmaceutical Industries Ltd
- Jul 27, 20293.0ypatentLumifybrimonidine tartrate$BLCOBausch & Lomb Corp
- Jul 27, 20293.0ypatentTalzennatalazoparib tosylate$PFEPFIZER INC
- Aug 6, 20293.1yNCEVoranigovorasidenib citrateLes Laboratoires Servier SAS
- Aug 9, 20293.1yNCEYorvipathpalopegteriparatideAscendis Pharma Inc
- Aug 18, 20293.1ypatentZyclaraimiquimodBausch Health US LLC
- Aug 19, 20293.1yNCELazcluzelazertinib mesylate$JNJJOHNSON & JOHNSON
- Aug 24, 20293.1ypatentAmphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamphetamine Sulfate(amphetamine aspartate + amfetamine [INN] + dextroamphetamine saccharate + dextroamphetamine sulfate)Actavis Elizabeth LLC
- Aug 29, 20293.1ypatentKimyrsaoritavancin [INN]Melinta Therapeutics LLC
- Aug 29, 20293.1ypatentOrbactivoritavancin diphosphateA. Menarini Industrie Farmaceutiche Riunite Srl
- Sep 3, 20293.2ypatentEvotaz(atazanavir sulfate + cobicistat)Bristol-Myers Squibb Co
- Sep 4, 20293.2ypatentQelbreeviloxazine hydrochloride$SUPNSUPERNUS PHARMACEUTICALS, INC.
- Sep 18, 20293.2ypatentLapatiniblapatinib ditosylateLupin Ltd
- Sep 19, 20293.2ypatentMILNACIPRAN HYDROCHLORIDEMILNACIPRAN HYDROCHLORIDEMylan Pharmaceuticals Inc
- Sep 20, 20293.2yODE-384Pedmarksodium thiosulfate$REGNREGENERON PHARMACEUTICALS, INC.
- Sep 22, 20293.2ypatentLonsurf(tipiracil hydrochloride + trifluridine)Taiho Oncology Inc
- Sep 24, 20293.2yNCEAqneursalevacetylleucineIntraBio Ltd
- Sep 26, 20293.2yNCECobenfy(trospium chloride + xanomeline tartrate)Bristol-Myers Squibb Co
- Sep 30, 20293.2ypatentMidolibuprofenBionpharma Inc
- Oct 5, 20293.2ypatentAmlodipine Besylateamlodipine besylateChina Resources Saike Pharmaceutical Co Ltd
- Oct 10, 20293.3yNCEItovebiinavolisibF. Hoffmann-La Roche Ltd
- Oct 13, 20293.3ypatentNuzolvencezoliflodacinEntasis Therapeutics Holdings Inc
- Oct 15, 20293.3ypatentVivitrolnaltrexone$AARDAardvark Therapeutics, Inc.
- Oct 21, 20293.3ypatentLarotrectinib Sulfate Bayerlarotrectinib sulfateBayer HealthCare Pharmaceuticals Inc
- Oct 22, 20293.3ypatentAliqopacopanlisib hydrochlorideBayer HealthCare Pharmaceuticals Inc
- Nov 6, 20293.3ypatentOxybutynin Hydrochlorideoxybutynin chlorideKVK-Tech Inc
- Nov 13, 20293.3ypatentBesivancebesifloxacin hydrochloride$BLCOBausch & Lomb Corp
- Nov 14, 20293.3yGAINFetrojacefiderocol sulfate tosylate$SGIOFSHIONOGI & CO LTD
- Nov 15, 20293.4yNCERevuforjrevumenib citrate$SNDXSyndax Pharmaceuticals Inc
- Nov 16, 20293.4ypatentPonvoryponesimod$VNDAVanda Pharmaceuticals Inc.
- Nov 17, 20293.4yODE-414Sezabyphenobarbital sodiumSun Pharmaceutical Industries Ltd
- Nov 20, 20293.4ypatentBelsomrasuvorexant$MRKMerck & Co., Inc.
- Nov 22, 20293.4yNCEAttrubyacoramidis hydrochloride$BBIOBridgeBio Pharma, Inc.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)