the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jul 14, 20292.8yODE-403DiacomitstiripentolBiocodex
- Jul 24, 20292.9ypatentOdomzosonidegib phosphateSun Pharmaceutical Industries Ltd
- Jul 25, 20292.9yNCELeqselvideuruxolitinib phosphateSun Pharmaceutical Industries Ltd
- Jul 27, 20292.9ypatentLumifybrimonidine tartrate$BLCOBausch & Lomb Corp
- Jul 27, 20292.9ypatentTalzennatalazoparib tosylate$PFEPFIZER INC
- Aug 6, 20292.9yNCEVoranigovorasidenib citrateLes Laboratoires Servier SAS
- Aug 9, 20292.9yNCEYorvipathpalopegteriparatideAscendis Pharma Inc
- Aug 14, 20292.9yGAINPretomanidpretomanidMylan Specialty LP
- Aug 14, 20292.9yNCELivdelziseladelpar lysineCymaBay Therapeutics Inc
- Aug 18, 20292.9ypatentZyclaraimiquimodBausch Health US LLC
- Aug 19, 20292.9yNCELazcluzelazertinib mesylate$JNJJOHNSON & JOHNSON
- Aug 24, 20292.9ypatentAmphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamphetamine Sulfate(amphetamine aspartate + amfetamine [INN] + dextroamphetamine saccharate + dextroamphetamine sulfate)Actavis Elizabeth LLC
- Aug 29, 20293.0ypatentKimyrsaoritavancin [INN]Melinta Therapeutics LLC
- Aug 29, 20293.0ypatentOrbactivoritavancin diphosphateA. Menarini Industrie Farmaceutiche Riunite Srl
- Sep 3, 20293.0ypatentEvotaz(atazanavir sulfate + cobicistat)Bristol-Myers Squibb Co
- Sep 3, 20293.0ypatentTybostcobicistat$GILDGILEAD SCIENCES, INC.
- Sep 4, 20293.0ypatentQelbreeviloxazine hydrochloride$SUPNSUPERNUS PHARMACEUTICALS, INC.
- Sep 18, 20293.0ypatentLapatiniblapatinib ditosylateLupin Ltd
- Sep 19, 20293.0ypatentMILNACIPRAN HYDROCHLORIDEMILNACIPRAN HYDROCHLORIDEMylan Pharmaceuticals Inc
- Sep 20, 20293.0yODE-384Pedmarksodium thiosulfate$REGNREGENERON PHARMACEUTICALS, INC.
- Sep 22, 20293.0ypatentLonsurf(tipiracil hydrochloride + trifluridine)Taiho Oncology Inc
- Sep 24, 20293.0yNCEAqneursalevacetylleucineIntraBio Ltd
- Sep 26, 20293.0yNCECobenfy(trospium chloride + xanomeline tartrate)Bristol-Myers Squibb Co
- Sep 30, 20293.0ypatentMidolibuprofenBionpharma Inc
- Oct 5, 20293.1ypatentAmlodipine Besylateamlodipine besylateChina Resources Saike Pharmaceutical Co Ltd
- Oct 10, 20293.1yNCEItovebiinavolisibF. Hoffmann-La Roche Ltd
- Oct 13, 20293.1ypatentNuzolvencezoliflodacinEntasis Therapeutics Holdings Inc
- Oct 15, 20293.1ypatentVivitrolnaltrexone$AARDAardvark Therapeutics, Inc.
- Oct 21, 20293.1ypatentLarotrectinib Sulfate Bayerlarotrectinib sulfateBayer HealthCare Pharmaceuticals Inc
- Oct 22, 20293.1ypatentLidocaine Hydrochloridelidocaine hydrochlorideInternational Medication Systems Ltd
- Oct 22, 20293.1ypatentAliqopacopanlisib hydrochlorideBayer HealthCare Pharmaceuticals Inc
- Nov 6, 20293.1ypatentOxybutynin Hydrochlorideoxybutynin chlorideKVK-Tech Inc
- Nov 13, 20293.2ypatentBesivancebesifloxacin hydrochloride$BLCOBausch & Lomb Corp
- Nov 14, 20293.2yGAINFetrojacefiderocol sulfate tosylate$SGIOFSHIONOGI & CO LTD
- Nov 15, 20293.2yNCERevuforjrevumenib citrate$SNDXSyndax Pharmaceuticals Inc
- Nov 16, 20293.2ypatentPonvoryponesimod$VNDAVanda Pharmaceuticals Inc.
- Nov 17, 20293.2yODE-414Sezabyphenobarbital sodiumSun Pharmaceutical Industries Ltd
- Nov 20, 20293.2ypatentBelsomrasuvorexant$MRKMerck & Co., Inc.
- Nov 22, 20293.2yNCEAttrubyacoramidis hydrochloride$BBIOBridgeBio Pharma, Inc.
- Nov 23, 20293.2ypatentOndansetronondansetronIpca Pharmaceuticals Inc
- Dec 13, 20293.2yNCECrenessitycrinecerfont$NBIXNEUROCRINE BIOSCIENCES INC
- Dec 16, 20293.3ypatentGiaprezaangiotensin II acetateLa Jolla Pharmaceutical Company
- Dec 22, 20293.3ypatentGimotimetoclopramide hydrochlorideEvoke Pharma Inc
- Jan 27, 20303.4ypatentRocklatan(latanoprost + netarsudil mesylate)$ALCALCON INC
- Jan 27, 20303.4ypatentRhopressanetarsudil mesylate$ALCALCON INC
- Jan 30, 20303.4yNCEJournavxsuzetrigine$VERXVertex, Inc.
- Feb 8, 20303.4ypatentDrospirenone + Ethinyl Estradiol + Levomefolate Calcium(drospirenone + ethinylestradiol + levomefolate calcium) + levomefolate calciumAllergan Sales LLC
- Feb 8, 20303.4ypatentSlynddrospirenoneExeltis USA Inc
- Feb 10, 20303.4ypatentNithiodote(sodium nitrite + sodium thiosulfate)Hope Biosciences LLC
- Feb 10, 20303.4ypatentSodium Nitritesodium nitriteHope Biosciences LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)