the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Mar 22, 20292.4yNCETryvioaprocitentanIdorsia Pharmaceuticals US Inc
- Mar 24, 20292.4ypatentNamzaric(donepezil hydrochloride + memantine hydrochloride)$ABBVAbbVie Inc.
- Mar 24, 20292.4ypatentMemantine Hydrochloridememantine hydrochloridePolygen Pharmaceuticals Inc
- Mar 25, 20292.4ypatentMonoferricferric derisomaltosePharmacosmos Therapeutics Inc
- Mar 26, 20292.4ypatentBelrapzobendamustine hydrochlorideEagle Pharmaceuticals Inc
- Mar 29, 20292.4ypatentQuillivant XRmethylphenidate hydrochlorideTris Pharma Inc
- Mar 29, 20292.4ypatentClonidine Hydrochlorideclonidine hydrochlorideFrontida Biopharm Inc
- Mar 29, 20292.4yNCEVoydeyadanicopanAlexion Pharmaceuticals Inc
- Apr 3, 20292.4yGAINZevteraceftobiprole medocarilInnoviva Specialty Therapeutics Inc
- Apr 6, 20292.4ypatentBrisdelleparoxetine mesylateLegacy Pharma Solutions
- Apr 15, 20292.5ypatentXiidralifitegrast$BLCOBausch & Lomb Corp
- Apr 16, 20292.5ypatentMultaqdronedarone hydrochlorideSanofi-Aventis US LLC
- Apr 21, 20292.5ypatentCiprofloxacinciprofloxacinBedford Laboratories
- Apr 23, 20292.5yNCEOjemdatovorafenib$DAWNDay One Biopharmaceuticals, Inc.
- Apr 26, 20292.5yNCEXolremdimavorixafor$XFORX4 Pharmaceuticals, Inc
- Apr 28, 20292.5ypatentEfavirenzefavirenzCamber Pharmaceuticals Inc
- Apr 28, 20292.5yODE-401Cuvriortrientine tetrahydrochlorideOrphalan SA
- May 4, 20292.5ypatentTafinlardabrafenib mesylate$NVSNOVARTIS AG
- May 12, 20292.5yODE-144Radicava ORSedaravone$SGIOFSHIONOGI & CO LTD
- May 13, 20292.5ypatentKengrealcangrelorChiesi USA Inc
- May 20, 20292.6ypatentBupivacaine Hydrochloridebupivacaine hydrochlorideOncoZenge AB
- May 21, 20292.6ypatentDdavpdesmopressin acetateFerring Pharmaceuticals Inc
- May 28, 20292.6ypatentZioptantafluprostThea Pharma Inc
- May 29, 20292.6ypatentMOXIFLOXACIN HYDROCHLORIDEMOXIFLOXACIN HYDROCHLORIDEAlvogen Inc
- Jun 3, 20292.6ypatentCabtreo(adapalene + benzoyl peroxide + clindamycin phosphate)Bausch Health US LLC
- Jun 3, 20292.6ypatentOrlynvah(probenecid [INN] + sulopenem etzadroxil)$ITRMFIterum Therapeutics plc
- Jun 10, 20292.6yNCEIqirvoelafibranorIpsen SA
- Jun 20, 20292.6ypatentZelborafvemurafenibF. Hoffmann-La Roche Ltd
- Jun 26, 20292.7ypatentMiplyffaarimoclomol citrate$ZVRAZEVRA THERAPEUTICS, INC.
- Jun 26, 20292.7yNCEOhtuvayreensifentrineVerona Pharma Ltd
- Jun 30, 20292.7ypatentTriptodurtriptorelin pamoateAzurity Pharmaceuticals Inc
- Jul 6, 20292.7ypatentOrilissaelagolix sodium$ABBVAbbVie Inc.
- Jul 8, 20292.7ypatentValchlormechlorethamine hydrochlorideHelsinn Therapeutics (US) Inc
- Jul 14, 20292.7yODE-403DiacomitstiripentolBiocodex
- Jul 24, 20292.7ypatentOdomzosonidegib phosphateSun Pharmaceutical Industries Ltd
- Jul 25, 20292.7yNCELeqselvideuruxolitinib phosphateSun Pharmaceutical Industries Ltd
- Jul 27, 20292.7ypatentLumifybrimonidine tartrate$BLCOBausch & Lomb Corp
- Jul 27, 20292.7ypatentTalzennatalazoparib tosylate$PFEPFIZER INC
- Aug 6, 20292.8yNCEVoranigovorasidenib citrateLes Laboratoires Servier SAS
- Aug 9, 20292.8yNCEYorvipathpalopegteriparatideAscendis Pharma Inc
- Aug 14, 20292.8yGAINPretomanidpretomanidMylan Specialty LP
- Aug 14, 20292.8yNCELivdelziseladelpar lysineCymaBay Therapeutics Inc
- Aug 18, 20292.8ypatentZyclaraimiquimodBausch Health US LLC
- Aug 19, 20292.8yNCELazcluzelazertinib mesylate$JNJJOHNSON & JOHNSON
- Aug 24, 20292.8ypatentAmphetamine Aspartate + Amphetamine Sulfate + Dextroamphetamine Saccharate + Dextroamphetamine Sulfate(amphetamine aspartate + amfetamine [INN] + dextroamphetamine saccharate + dextroamphetamine sulfate)Actavis Elizabeth LLC
- Aug 29, 20292.8ypatentKimyrsaoritavancin [INN]Melinta Therapeutics LLC
- Aug 29, 20292.8ypatentOrbactivoritavancin diphosphateA. Menarini Industrie Farmaceutiche Riunite Srl
- Sep 3, 20292.8ypatentEvotaz(atazanavir sulfate + cobicistat)Bristol-Myers Squibb Co
- Sep 3, 20292.8ypatentTybostcobicistat$GILDGILEAD SCIENCES, INC.
- Sep 4, 20292.8ypatentQelbreeviloxazine hydrochloride$SUPNSUPERNUS PHARMACEUTICALS, INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)