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  1. pharmadog
  2. ›drugs
  3. ›Talzenna
drug · small molecule
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talazoparib tosylate

Marketedupdated 3mo ago
by $PFE PFIZER INC🔗 ChEMBL
Approved
community read0 votes

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 2 investigational indications.

targets

Poly [ADP-ribose] polymerase 1Poly [ADP-ribose] polymerase 2

all catalysts(0)

nothing on the calendar yet

Trials studying talazoparib tosylate

  • phase1Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancerrecruitingn=45
  • —Korea Post Marketing Surveillance (PMS) Study of Talzenna®not yet recruitingn=600
  • phase2Talazoparib Monotherapy in PALB2 Mutation Associated Advanced Breast Cancerwithdrawn
  • phase1Talazoparib and Gemtuzumab Ozogamicin for the Treatment of CD33 Positive Relapsed or Refractory Acute Myeloid Leukemiacompletedn=24
  • phase1A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumorscompletedn=73

Patent cliff

source: FDA Orange Book
first barrier falls
Jul 27, 2029
~3.0 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (70)

  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 10189837
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Oct 20, 2031compositionUS 8735392
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029method-of-use (U-3651)US 107800883.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 80129763.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029compositionUS 84206503.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y
  • Jul 27, 2029method-of-use (U-2437)US 98209853.0y

FDA exclusivities (6)

  • Jun 20, 2026I-920Indication (3y)
  • Jun 20, 2026I-920Indication (3y)
  • Jun 20, 2026I-920Indication (3y)
  • Jun 20, 2026I-920Indication (3y)
  • Jun 20, 2026I-920Indication (3y)
  • Jun 20, 2026I-920Indication (3y)

News(1)

  • GU Cancer Experts Highlight Top Abstracts to Watch During ASCO 2026
    We spoke with leading voices in GU oncology to see which presentations they are most looking forward to during the 2026 ASCO Annual Meeting.
    onclive · 3mo ago
brand
Talzenna
trade names
Talzenna
generic
talazoparib tosylate
MOA
Poly [ADP-ribose] polymerase-1 inhibitor; Poly [ADP-ribose] polymerase 2 inhibitor
indication
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
phase
marketed
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed just now
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