drug · small molecule
vemurafenib
Marketedupdated 3mo agoby F. Hoffmann-La Roche Ltd🔗 ChEMBL
Approvedcommunity read0 votes
Small molecule drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 13 investigational indications.
indications
investigational
NSCLC
targets
Serine/threonine-protein kinase B-raf
all catalysts(0)
nothing on the calendar yet
Trials studying vemurafenib
- phase3A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
- phase2A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
- phase2TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
- phase1Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery
- phase2Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer
- phase2A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)
- phase2Phase II Trial of Vemurafenib and Sorafenib in Pancreatic Cancer
- phase2Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)
Patent cliff
source: FDA Orange Bookfirst barrier falls
Oct 22, 2026
65 days
Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.
patents (6)
- Jun 6, 2032formulationUS 9447089
- Jul 27, 2030compositionUS 87419203.9y
- Jun 20, 2029compositionUS 78632882.8y
- Oct 22, 2026compositionUS 750450965d
- Aug 2, 2026method-of-use (U-1418)US 8470818
- Jun 21, 2026compositionUS 8143271
News(1)
- Labcorp nabs FDA green light for BRAF melanoma diagnosticThe FDA has signed off on Labcorp’s companion diagnostic for patients with advanced melanoma carrying certain BRAF variants.fiercebiotech · 8d ago
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