the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Feb 3, 20292.4ypatentInbrijalevodopaPureIMS BV
- Feb 9, 20292.4ypatentEnsacoveensartinib hydrochlorideXcovery Holdings Inc
- Feb 10, 20292.4ypatentFirmagondegarelix acetateFerring Pharmaceuticals Inc
- Feb 13, 20292.4yNCERapiblyklandiolol hydrochlorideAOP Health
- Feb 21, 20292.4ypatentVyzultalatanoprostene bunod$BLCOBausch & Lomb Corp
- Feb 24, 20292.4ypatentCataflamdiclofenac potassiumAmici Pharmaceuticals LLC
- Mar 5, 20292.5ypatentBromfenac Sodiumbromfenac sodiumSentiss Pharmaceuticals LLC
- Mar 10, 20292.5ypatentOlumiantbaricitinibEli Lilly and Co
- Mar 11, 20292.5ypatentEpivirlamivudineViiV Healthcare Company
- Mar 12, 20292.5ypatentNITROGLYCERINNITROGLYCERINAllegis Pharmaceuticals Inc
- Mar 12, 20292.5ypatentNevirapinenevirapineCamber Pharmaceuticals Inc
- Mar 12, 20292.5ypatentRiluzole RisingriluzoleRising Pharma Holdings Inc
- Mar 13, 20292.5ypatentDuaklir Pressair(aclidinium bromide + formoterol fumarate)Covis Group Sarl
- Mar 13, 20292.5ypatentTudorza Pressairaclidinium bromideCovis Group Sarl
- Mar 13, 20292.5ypatentAmiodarone Hydrochlorideamiodarone hydrochlorideTaro Pharmaceutical Laboratories Inc (Inactive)
- Mar 13, 20292.5ypatentBrliziobrexanolone$LPCNLipocine Inc.
- Mar 13, 20292.5ypatentFosphenytoin Sodiumfosphenytoin sodiumWockhardt USA LLC
- Mar 13, 20292.5ypatentEvomelamelphalanZhaoke Ophthalmology Ltd
- Mar 14, 20292.5ypatentPhentermine Hydrochloridephentermine hydrochloridePolygen Pharmaceuticals Inc
- Mar 14, 20292.5yNCERezdiffraresmetirom$MDGLMADRIGAL PHARMACEUTICALS, INC.
- Mar 22, 20292.5yNCETryvioaprocitentanIdorsia Pharmaceuticals US Inc
- Mar 24, 20292.5ypatentNamzaric(donepezil hydrochloride + memantine hydrochloride)$ABBVAbbVie Inc.
- Mar 24, 20292.5ypatentMemantine Hydrochloridememantine hydrochloridePolygen Pharmaceuticals Inc
- Mar 25, 20292.5ypatentMonoferricferric derisomaltosePharmacosmos Therapeutics Inc
- Mar 26, 20292.5ypatentBelrapzobendamustine hydrochlorideEagle Pharmaceuticals Inc
- Mar 29, 20292.5ypatentQuillivant XRmethylphenidate hydrochlorideTris Pharma Inc
- Mar 29, 20292.5ypatentClonidine Hydrochlorideclonidine hydrochlorideFrontida Biopharm Inc
- Mar 29, 20292.5yNCEVoydeyadanicopanAlexion Pharmaceuticals Inc
- Apr 3, 20292.6yGAINZevteraceftobiprole medocarilInnoviva Specialty Therapeutics Inc
- Apr 6, 20292.6ypatentBrisdelleparoxetine mesylateLegacy Pharma Solutions
- Apr 15, 20292.6ypatentXiidralifitegrast$BLCOBausch & Lomb Corp
- Apr 16, 20292.6ypatentMultaqdronedarone hydrochlorideSanofi-Aventis US LLC
- Apr 21, 20292.6ypatentCiprofloxacinciprofloxacinBedford Laboratories
- Apr 23, 20292.6yNCEOjemdatovorafenib$DAWNDay One Biopharmaceuticals, Inc.
- Apr 26, 20292.6yNCEXolremdimavorixafor$XFORX4 Pharmaceuticals, Inc
- Apr 28, 20292.6ypatentEfavirenzefavirenzCamber Pharmaceuticals Inc
- Apr 28, 20292.6yODE-401Cuvriortrientine tetrahydrochlorideOrphalan SA
- May 12, 20292.7yODE-144Radicava ORSedaravone$SGIOFSHIONOGI & CO LTD
- May 13, 20292.7ypatentKengrealcangrelorChiesi USA Inc
- May 20, 20292.7ypatentBupivacaine Hydrochloridebupivacaine hydrochlorideOncoZenge AB
- May 21, 20292.7ypatentDdavpdesmopressin acetateFerring Pharmaceuticals Inc
- May 28, 20292.7ypatentZioptantafluprostThea Pharma Inc
- May 29, 20292.7ypatentMOXIFLOXACIN HYDROCHLORIDEMOXIFLOXACIN HYDROCHLORIDEAlvogen Inc
- Jun 3, 20292.7ypatentOrlynvah(probenecid [INN] + sulopenem etzadroxil)$ITRMFIterum Therapeutics plc
- Jun 10, 20292.7yNCEIqirvoelafibranorIpsen SA
- Jun 26, 20292.8ypatentMiplyffaarimoclomol citrate$ZVRAZEVRA THERAPEUTICS, INC.
- Jun 26, 20292.8yNCEOhtuvayreensifentrineVerona Pharma Ltd
- Jun 30, 20292.8ypatentTriptodurtriptorelin pamoateAzurity Pharmaceuticals Inc
- Jul 6, 20292.8ypatentOrilissaelagolix sodium$ABBVAbbVie Inc.
- Jul 8, 20292.8ypatentValchlormechlorethamine hydrochlorideHelsinn Therapeutics (US) Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)