the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Aug 27, 20282.1ypatentMIFEPRISTONEMIFEPRISTONE$CORTCORCEPT THERAPEUTICS INC
- Aug 27, 20282.1yGAINXeravaeravacycline dihydrochlorideLa Jolla Pharmaceutical Company
- Aug 27, 20282.1ypatentMayzentsiponimod fumarate$NVSNOVARTIS AG
- Sep 1, 20282.1ypatentDesoximetasonedesoximetasoneTeligent Inc
- Sep 4, 20282.2ypatentDaptomycindaptomycinXellia Pharmaceuticals USA LLC
- Sep 8, 20282.2yNCEmotixafortide acetate$BLRXBioLineRx Ltd.
- Sep 9, 20282.2yNPGEMCITABINE HYDROCHLORIDEGEMCITABINE HYDROCHLORIDE$JNJJOHNSON & JOHNSON
- Sep 12, 20282.2ypatentTobramycin SulfatetobramycinHikma Pharmaceuticals USA Inc
- Sep 13, 20282.2ypatentEslicarbazepine Acetateeslicarbazepine acetateShanghai Zhongxi Pharmaceutical Co Ltd
- Sep 15, 20282.2yM-317Airsupra(albuterol sulfate + budesonide)AstraZeneca Pharmaceuticals LP
- Sep 15, 20282.2yNCEOjjaaramomelotinib dihydrochlorideGlaxoSmithKline LLC
- Sep 16, 20282.2ypatentMovantiknaloxegol oxalateGrunenthal USA Inc
- Sep 22, 20282.2yNCEExxuagepirone hydrochlorideFabre-Kramer Pharmaceuticals Inc
- Sep 24, 20282.2yNPLIDOCAINELIDOCAINEMEDRx Co Ltd
- Sep 26, 20282.2yGAINClotrimazoleclotrimazolePL Developments Copiague LLC
- Oct 2, 20282.2yGAINNuzyraomadacycline tosylateParatek Pharmaceuticals Inc
- Oct 3, 20282.2ypatentTolsuraitraconazole$INTIInhibitor Therapeutics, Inc.
- Oct 6, 20282.2ypatentCOLCHICINECOLCHICINE$SCLXScilex Holding Co
- Oct 9, 20282.2ypatentMidostaurinmidostaurinLupin Ltd
- Oct 9, 20282.2ypatentXtampza ERoxycodone$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Oct 10, 20282.3ypatentTruqapcapivasertib$AZNASTRAZENECA PLC
- Oct 11, 20282.3ypatentPred Forteprednisolone acetate$ABBVAbbVie Inc.
- Oct 12, 20282.3yNCEVelsipityetrasimod$PFEPFIZER INC
- Oct 15, 20282.3ypatentLatanoprost GreenstonelatanoprostGreenstone LLC
- Oct 15, 20282.3ypatentNerlynxneratinib$PBYIPUMA BIOTECHNOLOGY, INC.
- Oct 16, 20282.3yNPFerahemeferumoxytolCovis Pharma BV
- Oct 16, 20282.3ypatentPropranolol Hydrochloridepropranolol hydrochloridePar Pharmaceutical Inc
- Oct 17, 20282.3ypatentQbrexzaglycopyrronium tosylate$DERMJourney Medical Corp
- Oct 17, 20282.3yNPPhotrexa Viscousriboflavin 5'-phosphate sodium$GKOSGLAUKOS Corp
- Oct 17, 20282.3yNCEZilbrysqzilucoplanUCB SA
- Oct 22, 20282.3yGAINContepofosfomycin disodium [INN]Meitheal Pharmaceuticals Inc
- Oct 24, 20282.3ypatentTigecyclinetigecyclineMeitheal Pharmaceuticals Inc
- Oct 26, 20282.3yNCEAgamreevamoroloneReveraGen BioPharma Inc
- Oct 27, 20282.3ypatentExondys 51eteplirsen$SRPTSarepta Therapeutics, Inc.
- Oct 30, 20282.3ypatentMyrbetriqmirabegronAstellas Pharma US Inc
- Oct 31, 20282.3ypatentYupelrirevefenacinTheravance Biopharma US Inc
- Oct 31, 20282.3yNCEZurzuvaezuranoloneSage Therapeutics Inc
- Nov 6, 20282.3ypatentTavalissefostamatinib disodium$RIGLRIGEL PHARMACEUTICALS INC
- Nov 7, 20282.3ypatentORIAHNN (COPACKAGED)ELAGOLIX SODIUM,ESTRADIOL,NORETHINDRONE ACETATE$ABBVAbbVie Inc.
- Nov 10, 20282.3ypatentCarbamazepinecarbamazepineRiconpharma LLC
- Nov 11, 20282.3ypatentErivedgevismodegibGenentech Inc
- Nov 15, 20282.4yGAINDefencath(heparin sodium + taurolidine [INN])$CRMDCorMedix Inc.
- Nov 15, 20282.4yNCEAugtyrorepotrectinibBristol-Myers Squibb Co
- Nov 16, 20282.4ypatentFotivdativozanib hydrochlorideAVEO Pharmaceuticals Inc
- Nov 19, 20282.4yM-82Igalmidexmedetomidine$BTAIBioXcel Therapeutics, Inc.
- Nov 22, 20282.4yODE-386FyarrosirolimusKaken Pharmaceutical Co Ltd
- Nov 26, 20282.4ypatentZyloprimallopurinolCasper Pharma LLC
- Nov 27, 20282.4yNCEOgsiveonirogacestat hydrobromideSpringWorks Therapeutics Inc
- Dec 5, 20282.4ypatentLoseasoniqueethinylestradiol + levonorgestrelTeva Pharmaceuticals USA Inc
- Dec 8, 20282.4ypatentEllaulipristal acetateHRA Pharma LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)