drug · small molecule
levodopa
Marketedupdated 3mo agoby PureIMS BV🔗 ChEMBL
Approvedcommunity read0 votes
🐶 often sniffed alongside
top 8- drugINBRIJA31 co-mentions · 8 sources
- tagApproval22 co-mentions · 6 sources
- druglevodopa CR21 co-mentions · 8 sources
- drugSINEMET CR12 co-mentions · 3 sources
- drugentacapone10 co-mentions · 2 sources
- tagRecall3 co-mentions · 1 sources
- companyRising Pharma Holdings Inc3 co-mentions · 1 sources
- drug(carbidopa + levodopa)1 co-mentions · 1 sources
Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for parkinson disease and injury and 22 investigational indications.
indications
investigational
Parkinson's Disease
targets
D(3) dopamine receptor
all catalysts(5)
approval · 5
Dec 21, 2018
approval
INBRIJA (LEVODOPA) — FDA approval
levodopa
→
Aug 29, 2019
approval
INBRIJA (LEVODOPA) — FDA approval
levodopa
→
Aug 31, 2020
approval
INBRIJA (LEVODOPA) — FDA approval
levodopa
→
Aug 31, 2020
approval
INBRIJA (LEVODOPA) — FDA approval
levodopa
→
Mar 31, 2026
approval
INBRIJA (LEVODOPA) — FDA approval
levodopa
→
Trials studying levodopa
- phase3A Study to Evaluate the Efficacy and Safety of HRG2010 in Parkinson's Disease With Motor Fluctuations
- phase1A Study to Assess Effect of Dosing Intervals on Multiple-Dose Pharmacokinetics of WD-1603 Taken Before Meals in Healthy Participants
- phase1A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops® Relative to INBRIJA®
- —Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease
- phase2Pharmacokinetics,Pharmacodynamics,Efficacy and Safety of HRG2010 in Parkinson's Disease Patients With Motor Fluctuations
- phase1A Safety, Tolerability, and Plasma Concentration Study of Levodopa/Carbidopa Subcutaneous Solution (ND0612) in Parkinson's Disease (PD) Patients
- phase2A Study to Evaluate SAGE-217 in Participants With Parkinson's Disease
- phase3A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD)
Patent cliff
source: FDA Orange Bookfirst barrier falls
Feb 3, 2029
~2.5 years out
Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.
patents (6)
- Oct 21, 2033method-of-use (U-2484)US 12458615
- Nov 16, 2032formulationUS 8545878
- Nov 16, 2032formulationUS 8685442
- Nov 16, 2032formulationUS 8945612
- Nov 16, 2032formulationUS 9393210
- Feb 3, 2029method-of-use (U-2484)US RE437112.5y
News(2)
- BioVie shares halve on murky Parkinson’s disease readoutBioVie’s stock fell by nearly 50% as the biotech claimed victory in a mid-stage Parkinson’s disease trial using an alternative endpoint to the primary clinical goal.biospace · 4d ago
- AbbVie shares pressured as Q2 I&I beat falls below investor expectationsAbbVie investors’ sky-high expectations led to a 4% share decline on Friday as the company reported more modest consensus beats than expected.biospace · 11d ago
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