the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Nov 11, 20282.0ypatentErivedgevismodegibGenentech Inc
- Nov 15, 20282.0yGAINDefencath(heparin sodium + taurolidine [INN])$CRMDCorMedix Inc.
- Nov 15, 20282.0yNCEAugtyrorepotrectinibBristol-Myers Squibb Co
- Nov 16, 20282.0ypatentFotivdativozanib hydrochlorideAVEO Pharmaceuticals Inc
- Nov 19, 20282.1yM-82Igalmidexmedetomidine$BTAIBioXcel Therapeutics, Inc.
- Nov 22, 20282.1yODE-386FyarrosirolimusKaken Pharmaceutical Co Ltd
- Nov 26, 20282.1ypatentZyloprimallopurinolCasper Pharma LLC
- Nov 27, 20282.1yNCEOgsiveonirogacestat hydrobromideSpringWorks Therapeutics Inc
- Dec 5, 20282.1ypatentLoseasoniqueethinylestradiol + levonorgestrelTeva Pharmaceuticals USA Inc
- Dec 8, 20282.1ypatentEllaulipristal acetateHRA Pharma LLC
- Dec 9, 20282.1yGAINRecarbrio(cilastatin sodium + imipenem + relebactam)$MRKMerck & Co., Inc.
- Dec 11, 20282.1yGAINBlujepagepotidacin mesylateGlaxoSmithKline LLC
- Dec 14, 20282.1ypatentCEFIXIMECEFIXIMELupin Ltd
- Dec 15, 20282.1ypatentQutenzacapsaicinGrunenthal GmbH
- Dec 15, 20282.1ypatentOrenitramtreprostinil diolamine$UTHRUNITED THERAPEUTICS Corp
- Dec 16, 20282.1ypatentCARIPRAZINE HYDROCHLORIDECARIPRAZINE HYDROCHLORIDE$ABBVAbbVie Inc.
- Dec 16, 20282.1yNPRevatiosildenafil citrate$VTRSViatris Inc
- Dec 18, 20282.1yNCEFilsuvezbirch triterpenesChiesi USA Inc
- Dec 19, 20282.1yNPPAccruferferric maltolShield TX (UK) Ltd
- Dec 19, 20282.1yI-979JascaydnerandomilastBoehringer Ingelheim International GmbH
- Dec 21, 20282.1yNCEWainuaeplontersen sodium$AZNASTRAZENECA PLC
- Jan 5, 20292.2yNCEZelsuvmiberdazimer sodium [INN]$PTHSPelthos Therapeutics Inc.
- Jan 5, 20292.2ypatentCopiktraduvelisibSecura Bio Inc
- Jan 7, 20292.2ypatentLAMOTRIGINELAMOTRIGINEIpca Pharmaceuticals Inc
- Jan 21, 20292.2yD-198VerquvovericiguatMerck Sharp & Dohme LLC
- Jan 28, 20292.2yNPYuvezzi(brimonidine tartrate + carbachol [INN])Tenpoint Therapeutics Ltd
- Jan 28, 20292.2ypatentMyfembree(estradiol + norethindrone acetate + relugolix)Sumitomo Pharma America Inc
- Jan 28, 20292.2ypatentOrgovyxrelugolixSumitomo Pharma America Inc
- Feb 3, 20292.3ypatentPROGESTERONEPROGESTERONEIBSA Institut Biochimique SA
- Feb 3, 20292.3ypatentInbrijalevodopaPureIMS BV
- Feb 9, 20292.3ypatentEnsacoveensartinib hydrochlorideXcovery Holdings Inc
- Feb 10, 20292.3ypatentFirmagondegarelix acetateFerring Pharmaceuticals Inc
- Feb 13, 20292.3yNCERapiblyklandiolol hydrochlorideAOP Health
- Feb 21, 20292.3ypatentVyzultalatanoprostene bunod$BLCOBausch & Lomb Corp
- Feb 24, 20292.3ypatentCataflamdiclofenac potassiumAmici Pharmaceuticals LLC
- Mar 5, 20292.3ypatentBromfenac Sodiumbromfenac sodiumSentiss Pharmaceuticals LLC
- Mar 10, 20292.4ypatentMethotrexate Sodiummethotrexate$PFEPFIZER INC
- Mar 10, 20292.4ypatentOlumiantbaricitinibEli Lilly and Co
- Mar 11, 20292.4ypatentEpivirlamivudineViiV Healthcare Company
- Mar 12, 20292.4ypatentNITROGLYCERINNITROGLYCERINAllegis Pharmaceuticals Inc
- Mar 12, 20292.4ypatentNevirapinenevirapineCamber Pharmaceuticals Inc
- Mar 12, 20292.4ypatentRiluzole RisingriluzoleRising Pharma Holdings Inc
- Mar 13, 20292.4ypatentDuaklir Pressair(aclidinium bromide + formoterol fumarate)Covis Group Sarl
- Mar 13, 20292.4ypatentTudorza Pressairaclidinium bromideCovis Group Sarl
- Mar 13, 20292.4ypatentAmiodarone Hydrochlorideamiodarone hydrochlorideTaro Pharmaceutical Laboratories Inc (Inactive)
- Mar 13, 20292.4ypatentBrliziobrexanolone$LPCNLipocine Inc.
- Mar 13, 20292.4ypatentFosphenytoin Sodiumfosphenytoin sodiumWockhardt USA LLC
- Mar 13, 20292.4ypatentEvomelamelphalanZhaoke Ophthalmology Ltd
- Mar 14, 20292.4ypatentPhentermine Hydrochloridephentermine hydrochloridePolygen Pharmaceuticals Inc
- Mar 14, 20292.4yNCERezdiffraresmetirom$MDGLMADRIGAL PHARMACEUTICALS, INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)