the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Aug 14, 20281.8ypatentBetapacesotalol hydrochlorideCovis Pharmaceuticals Inc (Inactive)
- Aug 15, 20281.8yNPCyclobenzaprine Hydrochloridecyclobenzaprine hydrochloridePliva Inc (Inactive)
- Aug 15, 20281.8ypatentILLUCCIXGALLIUM GA-68 GOZETOTIDE$TLXTelix Pharmaceuticals Ltd
- Aug 16, 20281.8yNCESohonospalovaroteneIpsen Biopharmaceuticals Inc
- Aug 22, 20281.8ypatentVanrafiaatrasentan hydrochloride$NVSNOVARTIS AG
- Aug 23, 20281.8ypatentBUPROPION HYDROCHLORIDEBUPROPION HYDROCHLORIDEApnar Pharma LP
- Aug 25, 20281.8yODE-368TibsovoivosidenibLes Laboratoires Servier SAS
- Aug 27, 20281.8ypatentMIFEPRISTONEMIFEPRISTONE$CORTCORCEPT THERAPEUTICS INC
- Aug 27, 20281.8yGAINXeravaeravacycline dihydrochlorideLa Jolla Pharmaceutical Company
- Aug 27, 20281.8ypatentMayzentsiponimod fumarate$NVSNOVARTIS AG
- Sep 1, 20281.8ypatentDesoximetasonedesoximetasoneTeligent Inc
- Sep 4, 20281.8ypatentDaptomycindaptomycinXellia Pharmaceuticals USA LLC
- Sep 8, 20281.9yNCEmotixafortide acetate$BLRXBioLineRx Ltd.
- Sep 9, 20281.9yNPGEMCITABINE HYDROCHLORIDEGEMCITABINE HYDROCHLORIDE$JNJJOHNSON & JOHNSON
- Sep 12, 20281.9ypatentTobramycin SulfatetobramycinHikma Pharmaceuticals USA Inc
- Sep 13, 20281.9ypatentEslicarbazepine Acetateeslicarbazepine acetateShanghai Zhongxi Pharmaceutical Co Ltd
- Sep 15, 20281.9yM-317Airsupra(albuterol sulfate + budesonide)AstraZeneca Pharmaceuticals LP
- Sep 15, 20281.9yNCEOjjaaramomelotinib dihydrochlorideGlaxoSmithKline LLC
- Sep 16, 20281.9ypatentMovantiknaloxegol oxalateGrunenthal USA Inc
- Sep 17, 20281.9yODE-375Cometriqcabozantinib s-malate$EXELEXELIXIS, INC.
- Sep 22, 20281.9yNCEExxuagepirone hydrochlorideFabre-Kramer Pharmaceuticals Inc
- Sep 24, 20281.9yNPLIDOCAINELIDOCAINEMEDRx Co Ltd
- Sep 26, 20281.9yGAINClotrimazoleclotrimazolePL Developments Copiague LLC
- Oct 2, 20281.9yGAINNuzyraomadacycline tosylateParatek Pharmaceuticals Inc
- Oct 3, 20281.9ypatentTolsuraitraconazole$INTIInhibitor Therapeutics, Inc.
- Oct 6, 20281.9ypatentCOLCHICINECOLCHICINE$SCLXScilex Holding Co
- Oct 7, 20281.9yODE-377TavneosavacopanChemoCentryx Inc
- Oct 9, 20281.9ypatentMidostaurinmidostaurinLupin Ltd
- Oct 9, 20281.9ypatentXtampza ERoxycodone$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Oct 10, 20281.9ypatentTruqapcapivasertib$AZNASTRAZENECA PLC
- Oct 11, 20281.9ypatentGLYCOPYRROLATEGLYCOPYRROLATEExela Pharma Sciences LLC
- Oct 11, 20281.9ypatentPred Forteprednisolone acetate$ABBVAbbVie Inc.
- Oct 12, 20282.0yNCEVelsipityetrasimod$PFEPFIZER INC
- Oct 15, 20282.0ypatentLatanoprost GreenstonelatanoprostGreenstone LLC
- Oct 15, 20282.0ypatentNerlynxneratinib$PBYIPUMA BIOTECHNOLOGY, INC.
- Oct 16, 20282.0yNPFerahemeferumoxytolCovis Pharma BV
- Oct 16, 20282.0ypatentPropranolol Hydrochloridepropranolol hydrochloridePar Pharmaceutical Inc
- Oct 17, 20282.0ypatentQbrexzaglycopyrronium tosylate$DERMJourney Medical Corp
- Oct 17, 20282.0yNPPhotrexa Viscousriboflavin 5'-phosphate sodium$GKOSGLAUKOS Corp
- Oct 17, 20282.0yNCEZilbrysqzilucoplanUCB SA
- Oct 22, 20282.0yGAINContepofosfomycin disodium [INN]Meitheal Pharmaceuticals Inc
- Oct 24, 20282.0ypatentTigecyclinetigecyclineMeitheal Pharmaceuticals Inc
- Oct 26, 20282.0yNCEAgamreevamoroloneReveraGen BioPharma Inc
- Oct 27, 20282.0ypatentExondys 51eteplirsen$SRPTSarepta Therapeutics, Inc.
- Oct 30, 20282.0ypatentMyrbetriqmirabegronAstellas Pharma US Inc
- Oct 31, 20282.0ypatentYupelrirevefenacinTheravance Biopharma US Inc
- Oct 31, 20282.0yNCEZurzuvaezuranoloneSage Therapeutics Inc
- Nov 6, 20282.0ypatentTavalissefostamatinib disodium$RIGLRIGEL PHARMACEUTICALS INC
- Nov 7, 20282.0ypatentORIAHNN (COPACKAGED)ELAGOLIX SODIUM,ESTRADIOL,NORETHINDRONE ACETATE$ABBVAbbVie Inc.
- Nov 10, 20282.0ypatentCarbamazepinecarbamazepineRiconpharma LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)