the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jun 25, 20281.8yGAINZemdriplazomicin sulfateCipla USA Inc
- Jun 27, 20281.8ypatentKazano(alogliptin benzoate + metformin hydrochloride)Takeda Pharmaceuticals USA Inc
- Jun 27, 20281.8ypatentOseni(alogliptin benzoate + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jun 27, 20281.8ypatentAlogliptin Benzoate Perrigoalogliptin benzoatePerrigo New York Inc
- Jun 29, 20281.8ypatentDaurismoglasdegib$PFEPFIZER INC
- Jul 1, 20281.8ypatentEVEROLIMUSEVEROLIMUSNovugen Pharma (Malaysia) Sdn Bhd
- Jul 7, 20281.8ypatentViberzieluxadoline$ABBVAbbVie Inc.
- Jul 9, 20281.8ypatentOsphenaospemifeneDuchesnay USA Inc
- Jul 10, 20281.8ypatentTwirla(ethinylestradiol + levonorgestrel)Agile Therapeutics Inc
- Jul 10, 20281.8yM-14PRUCALOPRIDE SUCCINATEPRUCALOPRIDE SUCCINATESpecGx LLC
- Jul 10, 20281.8ypatentEstradiol NovenestradiolNoven Pharmaceuticals Inc
- Jul 11, 20281.8yI-970KerendiafinerenoneBayer AG
- Jul 15, 20281.8ypatentFlonase Sensimistfluticasone furoateGlaxoSmithKline LLC
- Jul 16, 20281.8yODE-362Rezurockbelumosudil mesylateKadmon Pharmaceuticals LLC
- Jul 16, 20281.8yODE-359FexinidazolefexinidazoleSanofi-Aventis US LLC
- Jul 20, 20281.8yODE-363BylvayodevixibatIpsen SA
- Jul 21, 20281.8yNCEYcanthcantharidin$VRCAVerrica Pharmaceuticals Inc.
- Jul 24, 20281.9yNCEXdemvylotilaner$TARSTarsus Pharmaceuticals, Inc.
- Jul 27, 20281.9ypatentBivalirudinbivalirudinAvenacy Inc
- Jul 29, 20281.9ypatentMulpletalusutrombopag$SGIOFSHIONOGI & CO LTD
- Aug 6, 20281.9ypatentDronabinoldronabinolVertanical GmbH
- Aug 7, 20281.9ypatentIntrarosaprasteroneCosette Pharmaceuticals Inc
- Aug 8, 20281.9ypatentCaprelsavandetanibGenzyme Corp
- Aug 10, 20281.9ypatentSeysarasarecycline hydrochlorideAlmirall SA
- Aug 14, 20281.9ypatentBetapacesotalol hydrochlorideCovis Pharmaceuticals Inc (Inactive)
- Aug 15, 20281.9yNPCyclobenzaprine Hydrochloridecyclobenzaprine hydrochloridePliva Inc (Inactive)
- Aug 15, 20281.9ypatentILLUCCIXGALLIUM GA-68 GOZETOTIDE$TLXTelix Pharmaceuticals Ltd
- Aug 16, 20281.9yNCESohonospalovaroteneIpsen Biopharmaceuticals Inc
- Aug 22, 20281.9ypatentVanrafiaatrasentan hydrochloride$NVSNOVARTIS AG
- Aug 23, 20281.9ypatentBUPROPION HYDROCHLORIDEBUPROPION HYDROCHLORIDEApnar Pharma LP
- Aug 27, 20282.0ypatentMIFEPRISTONEMIFEPRISTONE$CORTCORCEPT THERAPEUTICS INC
- Aug 27, 20282.0yGAINXeravaeravacycline dihydrochlorideLa Jolla Pharmaceutical Company
- Aug 27, 20282.0ypatentMayzentsiponimod fumarate$NVSNOVARTIS AG
- Sep 1, 20282.0ypatentDesoximetasonedesoximetasoneTeligent Inc
- Sep 4, 20282.0ypatentDaptomycindaptomycinXellia Pharmaceuticals USA LLC
- Sep 8, 20282.0yNCEmotixafortide acetate$BLRXBioLineRx Ltd.
- Sep 9, 20282.0yNPGEMCITABINE HYDROCHLORIDEGEMCITABINE HYDROCHLORIDE$JNJJOHNSON & JOHNSON
- Sep 12, 20282.0ypatentTobramycin SulfatetobramycinHikma Pharmaceuticals USA Inc
- Sep 13, 20282.0ypatentEslicarbazepine Acetateeslicarbazepine acetateShanghai Zhongxi Pharmaceutical Co Ltd
- Sep 15, 20282.0yM-317Airsupra(albuterol sulfate + budesonide)AstraZeneca Pharmaceuticals LP
- Sep 15, 20282.0yNCEOjjaaramomelotinib dihydrochlorideGlaxoSmithKline LLC
- Sep 16, 20282.0ypatentMovantiknaloxegol oxalateGrunenthal USA Inc
- Sep 17, 20282.0yODE-375Cometriqcabozantinib s-malate$EXELEXELIXIS, INC.
- Sep 22, 20282.0yNCEExxuagepirone hydrochlorideFabre-Kramer Pharmaceuticals Inc
- Sep 24, 20282.0yNPLIDOCAINELIDOCAINEMEDRx Co Ltd
- Sep 26, 20282.0yGAINClotrimazoleclotrimazolePL Developments Copiague LLC
- Oct 2, 20282.0yGAINNuzyraomadacycline tosylateParatek Pharmaceuticals Inc
- Oct 3, 20282.1ypatentTolsuraitraconazole$INTIInhibitor Therapeutics, Inc.
- Oct 6, 20282.1ypatentCOLCHICINECOLCHICINE$SCLXScilex Holding Co
- Oct 9, 20282.1ypatentMidostaurinmidostaurinLupin Ltd
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)