the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Apr 26, 20281.8ypatentPramipexole Dihydrochloridepramipexole dihydrochlorideShasun USA Inc
- Apr 30, 20281.8yNPMigranaldihydroergotamine mesylateBausch Health US LLC
- Apr 30, 20281.8yODE-417FerriproxdeferiproneChiesi USA Inc
- Apr 30, 20281.8ypatentNicorettenicotine [USP]NAL Pharmaceuticals Ltd
- May 1, 20281.8ypatentClozarilclozapineHeritage Health Systems Inc
- May 2, 20281.8ypatentUpneeqoxymetazoline hydrochlorideRVL Pharmaceuticals Inc
- May 4, 20281.8ypatentInpefasotagliflozin$LXRXLEXICON PHARMACEUTICALS, INC.
- May 7, 20281.8ypatentCalcipotriene PrascocalcipotrienePrasco LLC
- May 9, 20281.8ypatentAddyiflibanserinSprout2 Inc
- May 9, 20281.8ypatentFruzaqlafruquintinibTakeda Pharmaceuticals USA Inc
- May 12, 20281.8yNCEVeozahfezolinetantAstellas Pharma US Inc
- May 15, 20281.8ypatentZerbaxa(ceftolozane sulfate + tazobactam sodium)$MRKMerck & Co., Inc.
- May 18, 20281.9yNCEMieboperfluorohexyloctane$BLCOBausch & Lomb Corp
- May 23, 20281.9ypatentDalvancedalbavancinAllergan Sales LLC
- May 28, 20281.9yODE-353infigratinib phosphateQED Therapeutics Inc
- May 30, 20281.9ypatentEnvarsus XRtacrolimusVeloxis Pharmaceuticals Inc
- Jun 3, 20281.9yI-971NubeqadarolutamideBayer HealthCare Pharmaceuticals Inc
- Jun 3, 20281.9ypatentDoralquazepamGALT Pharmaceuticals LLC
- Jun 4, 20281.9ypatentAzelastine Hydrochloride Wallaceazelastine hydrochlorideWallace Pharmaceuticals Inc
- Jun 4, 20281.9yODE-354TembexabrincidofovirSymBio Pharmaceuticals Ltd
- Jun 5, 20281.9yNPWidaplik(amlodipine besylate + indapamide + telmisartan)Azurity Pharmaceuticals Inc
- Jun 11, 20281.9yM-14DoxercalciferoldoxercalciferolHospira Inc
- Jun 17, 20281.9yI-984POSACONAZOLEPOSACONAZOLEPar Sterile Products LLC
- Jun 19, 20281.9ypatentCardamystetripamil$MISTMilestone Pharmaceuticals Inc.
- Jun 20, 20281.9yM-316Descovy(emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Jun 23, 20282.0yNCELitfuloritlecitinib [INN]$PFEPFIZER INC
- Jun 25, 20282.0yGAINZemdriplazomicin sulfateCipla USA Inc
- Jun 27, 20282.0ypatentOseni(alogliptin benzoate + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jun 29, 20282.0ypatentDaurismoglasdegib$PFEPFIZER INC
- Jul 1, 20282.0ypatentEVEROLIMUSEVEROLIMUSNovugen Pharma (Malaysia) Sdn Bhd
- Jul 7, 20282.0ypatentViberzieluxadoline$ABBVAbbVie Inc.
- Jul 10, 20282.0ypatentTwirla(ethinylestradiol + levonorgestrel)Agile Therapeutics Inc
- Jul 10, 20282.0yM-14PRUCALOPRIDE SUCCINATEPRUCALOPRIDE SUCCINATESpecGx LLC
- Jul 10, 20282.0ypatentEstradiol NovenestradiolNoven Pharmaceuticals Inc
- Jul 11, 20282.0yI-970KerendiafinerenoneBayer AG
- Jul 15, 20282.0ypatentFlonase Sensimistfluticasone furoateGlaxoSmithKline LLC
- Jul 21, 20282.0yNCEYcanthcantharidin$VRCAVerrica Pharmaceuticals Inc.
- Jul 24, 20282.0yNCEXdemvylotilaner$TARSTarsus Pharmaceuticals, Inc.
- Jul 27, 20282.0ypatentBivalirudinbivalirudinAvenacy Inc
- Jul 29, 20282.1ypatentMulpletalusutrombopag$SGIOFSHIONOGI & CO LTD
- Aug 6, 20282.1ypatentDronabinoldronabinolVertanical GmbH
- Aug 7, 20282.1ypatentIntrarosaprasteroneCosette Pharmaceuticals Inc
- Aug 8, 20282.1ypatentCaprelsavandetanibGenzyme Corp
- Aug 10, 20282.1ypatentSeysarasarecycline hydrochlorideAlmirall SA
- Aug 14, 20282.1ypatentBetapacesotalol hydrochlorideCovis Pharmaceuticals Inc (Inactive)
- Aug 15, 20282.1yNPCyclobenzaprine Hydrochloridecyclobenzaprine hydrochloridePliva Inc (Inactive)
- Aug 15, 20282.1ypatentILLUCCIXGALLIUM GA-68 GOZETOTIDE$TLXTelix Pharmaceuticals Ltd
- Aug 16, 20282.1yNCESohonospalovaroteneIpsen Biopharmaceuticals Inc
- Aug 22, 20282.1ypatentVanrafiaatrasentan hydrochloride$NVSNOVARTIS AG
- Aug 23, 20282.1ypatentBUPROPION HYDROCHLORIDEBUPROPION HYDROCHLORIDEApnar Pharma LP
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)