the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Dec 1, 20271.2yODE-329Hetlioztasimelteon$VNDAVanda Pharmaceuticals Inc.
- Dec 3, 20271.2yNPOrladeyoberotralstat hydrochloride$BCRXBIOCRYST PHARMACEUTICALS INC
- Dec 3, 20271.2ypatentCefepime Hydrochloridecefepime hydrochlorideSamson Medical Technologies LLC
- Dec 10, 20271.2ypatentDeoxycholic Aciddeoxycholic acidSlayback Pharma LLC
- Dec 11, 20271.2ypatentAMBRISENTANAMBRISENTANSigmapharm Laboratories LLC
- Dec 11, 20271.2ypatentVALGANCICLOVIR HYDROCHLORIDEVALGANCICLOVIR HYDROCHLORIDENovadoz Pharmaceuticals LLC
- Dec 11, 20271.2ypatentXermelotelotristat ethylTerSera Therapeutics LLC
- Dec 12, 20271.2yNCEKrazatiadagrasibBristol-Myers Squibb Co
- Dec 12, 20271.2ypatentLodonalnaltrexone hydrochlorideBiostax Corp
- Dec 12, 20271.2yNPPSugammadex Sodiumsugammadex sodiumB. Braun Medical Inc
- Dec 18, 20271.3ypatentTrelegy Ellipta(fluticasone furoate + umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Dec 18, 20271.3ypatentIncruse Elliptaumeclidinium bromideGlaxoSmithKline LLC
- Dec 18, 20271.3yI-955GemtesavibegronSumitomo Pharma America Inc
- Dec 19, 20271.3ypatentTobradex ST(dexamethasone + tobramycin)$HROWHARROW, INC.
- Dec 19, 20271.3yM-187Xofluzabaloxavir marboxil$SGIOFSHIONOGI & CO LTD
- Dec 19, 20271.3ypatentDoxycycline PrascodoxycyclinePrasco LLC
- Dec 20, 20271.3yM-270SkyclarysomaveloxoloneReata Pharmaceuticals Inc
- Dec 22, 20271.3yNCESunlencalenacapavir sodium$GILDGILEAD SCIENCES, INC.
- Dec 24, 20271.3ypatentNexavarsorafenib tosylateBayer HealthCare Pharmaceuticals Inc
- Dec 25, 20271.3ypatentFINGOLIMOD HYDROCHLORIDEFINGOLIMOD HYDROCHLORIDEEzra Ventures LLC
- Dec 28, 20271.3ypatentBOSENTANBOSENTAN$NSRXNasus Pharma Ltd
- Jan 3, 20281.3ypatentEFINACONAZOLEEFINACONAZOLEOrtho Dermatologics Inc
- Jan 7, 20281.3ypatentTrabectedintrabectedin$JNJJOHNSON & JOHNSON
- Jan 9, 20281.3ypatentActonelrisedronate sodiumAllergan Finance LLC
- Jan 15, 20281.3ypatentNextstellis(drospirenone + estetrol)Mayne Pharma USA Inc
- Jan 16, 20281.3yI-962Lumakrassotorasib$AMGNAMGEN INC
- Jan 18, 20281.3ypatentNayzilammidazolam [INN]UCB SA
- Jan 20, 20281.3yNCEBrenzavvybexagliflozinTheracosBio LLC
- Jan 22, 20281.4ypatentGocovriamantadine hydrochlorideAdamas Pharmaceuticals Inc
- Jan 22, 20281.4yODE-345Carbaglucarglumic acidRecordati Rare Diseases Inc
- Jan 27, 20281.4yNCEOrserduelacestrant hydrochlorideA. Menarini Industrie Farmaceutiche Riunite Srl
- Jan 27, 20281.4yI-981JaypircapirtobrutinibEli Lilly and Co
- Jan 28, 20281.4ypatentRaltegravirraltegravir potassiumLupin Ltd
- Jan 30, 20281.4ypatentNatazia(dienogest + estradiol valerate)Bayer HealthCare Pharmaceuticals Inc
- Jan 30, 20281.4yNPSymbravo(meloxicam + rizatriptan benzoate)$AXSMAxsome Therapeutics, Inc.
- Jan 30, 20281.4ypatentTrulanceplecanatideSalix Pharmaceuticals Ltd
- Jan 31, 20281.4yD-195PAXLOVID (COPACKAGED)NIRMATRELVIR$PFEPFIZER INC
- Feb 1, 20281.4ypatentAlvescociclesonideCovis Pharmaceuticals Inc (Inactive)
- Feb 2, 20281.4ypatentMETRONIDAZOLEMETRONIDAZOLESaptalis Pharmaceuticals LLC
- Feb 3, 20281.4ypatentTwyneo(benzoyl peroxide + tretinoin)Mayne Pharma USA Inc
- Feb 3, 20281.4ypatentDOXYCYCLINE HYCLATEDOXYCYCLINE HYCLATE$AMRXAmneal Pharmaceuticals, Inc.
- Feb 3, 20281.4yNPApomorphine Hydrochlorideapomorphine hydrochlorideTruPharma LLC
- Feb 3, 20281.4ypatentEpsolaybenzoyl peroxideGalderma Laboratories LP
- Feb 3, 20281.4yODE-325Tepmetkotepotinib hydrochlorideEMD Serono Inc
- Feb 5, 20281.4ypatentZOLEDRONIC ACIDZOLEDRONIC ACIDAvenacy Inc
- Feb 7, 20281.4ypatentDimethyl Fumaratedimethyl fumarateSOLA Pharmaceuticals Inc
- Feb 7, 20281.4yNPPMoxidectinmoxidectinAtticus Medical Pty Ltd
- Feb 17, 20281.4ypatentReyvowlasmiditanEli Lilly and Co
- Feb 17, 20281.4yNCEFilsparisparsentan$TVTXTravere Therapeutics, Inc.
- Feb 21, 20281.4yNPChenodalchenodiol$MIRMMirum Pharmaceuticals, Inc.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)