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  1. pharmadog
  2. ›drugs
  3. ›Daybue
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trofinetide

Marketedupdated 3mo ago
by $ACAD ACADIA PHARMACEUTICALS INC
Approved
community read0 votes

🐶 often sniffed alongside

top 4
  • tagApproval28 co-mentions · 7 sources
  • drugDAYBUE28 co-mentions · 7 sources
  • drugDAYBUE STIX28 co-mentions · 7 sources
  • tagSmall Molecule14 co-mentions · 7 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for rett syndrome and 5 investigational indications.

all catalysts(7)

approval · 7
Mar 10, 2023
approval
$ACAD29.01+2.73%
3y ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→
Sep 30, 2024
approval
$ACAD29.01+2.73%
2y ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→
Sep 30, 2024
approval
$ACAD29.01+2.73%
2y ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→
Aug 5, 2025
approval
$ACAD29.01+2.73%
1y ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→
Aug 5, 2025
approval
$ACAD29.01+2.73%
1y ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→
Dec 11, 2025
approval
$ACAD29.01+2.73%
8mo ago
DAYBUE STIX (TROFINETIDE) — FDA approval
trofinetide
→
Mar 27, 2026
approval
$ACAD29.01+2.73%
5mo ago
DAYBUE (TROFINETIDE) — FDA approval
trofinetide
→

Trials studying trofinetide

  • phase3Open-Label Extension Study of Trofinetide for Rett Syndrometerminatedn=77
  • phase3An Open-Label Study of Trofinetide for the Treatment of Girls Two to Five Years of Age Who Have Rett Syndrometerminatedn=15
  • phase3Open-Label Extension Study of Trofinetide for the Treatment of Girls and Women With Rett Syndromecompletedn=154
  • phase3Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome (LAVENDER™)completedn=187

Patent cliff

source: FDA Orange Book
first barrier falls
Mar 10, 2028
~1.6 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (32)

  • Jan 12, 2043patentUS 11827600*PED
  • Jan 12, 2043patentUS 11827600*PED
  • Jan 12, 2043patentUS 11827600*PED
  • Jan 12, 2043patentUS 11827600*PED
  • Jan 12, 2043patentUS 12492167*PED
  • Jan 12, 2043patentUS 12492167*PED
  • Jan 12, 2043patentUS 12492167*PED
  • Jan 12, 2043patentUS 12492167*PED
  • Jul 12, 2042compositionUS 11827600
  • Jul 12, 2042compositionUS 11827600
  • Jul 12, 2042compositionUS 11827600
  • Jul 12, 2042compositionUS 11827600
  • Jul 12, 2042compositionUS 12492167
  • Jul 12, 2042compositionUS 12492167
  • Jul 12, 2042compositionUS 12492167
  • Jul 12, 2042compositionUS 12492167
  • Feb 3, 2041patentUS 11370755*PED
  • Feb 3, 2041patentUS 11370755*PED
  • Feb 3, 2041patentUS 11370755*PED
  • Feb 3, 2041patentUS 11370755*PED
  • Aug 3, 2040compositionUS 11370755
  • Aug 3, 2040compositionUS 11370755
  • Aug 3, 2040compositionUS 11370755
  • Aug 3, 2040compositionUS 11370755
  • Jul 27, 2032patentUS 9212204*PED
  • Jul 27, 2032patentUS 9212204*PED
  • Jul 27, 2032patentUS 9212204*PED
  • Jul 27, 2032patentUS 9212204*PED
  • Jan 27, 2032method-of-use (U-3556)US 9212204
  • Jan 27, 2032method-of-use (U-3556)US 9212204
  • Jan 27, 2032method-of-use (U-3556)US 9212204
  • Jan 27, 2032method-of-use (U-3556)US 9212204

FDA exclusivities (16)

  • Sep 10, 2030PEDPediatric (6mo bonus)4.1y
  • Sep 10, 2030PEDPediatric (6mo bonus)4.1y
  • Sep 10, 2030PEDPediatric (6mo bonus)4.1y
  • Sep 10, 2030PEDPediatric (6mo bonus)4.1y
  • Mar 10, 2030ODE*ODE*3.6y
  • Mar 10, 2030ODE-425Orphan Drug (7y)3.6y
  • Mar 10, 2030ODE*ODE*3.6y
  • Mar 10, 2030ODE*ODE*3.6y
  • Sep 10, 2028PEDPediatric (6mo bonus)2.1y
  • Sep 10, 2028PEDPediatric (6mo bonus)2.1y
  • Sep 10, 2028PEDPediatric (6mo bonus)2.1y
  • Sep 10, 2028PEDPediatric (6mo bonus)2.1y
  • Mar 10, 2028NCENew Chemical Entity (5y)1.6y
  • Mar 10, 2028NCENew Chemical Entity (5y)1.6y
  • Mar 10, 2028NCENew Chemical Entity (5y)1.6y
  • Mar 10, 2028NCENew Chemical Entity (5y)1.6y

News(1)

  • On second try, Acadia drug gets nod from European regulators
    The influential CHMP committee also threw its support behind more than a dozen other medicines while recommending the marketing authorization for Tavneos be revoked.
    biopharma_dive · 1mo ago
brand
Daybue
generic
trofinetide
MOA
12.1 Mechanism of Action The mechanism by which trofinetide exerts therapeutic effects in patients with Rett syndrome is unknown.
indication
Rett Syndrome
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 28m ago
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