the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Sep 15, 20271.2yGAINSolosecsecnidazole$EVFMEvofem Biosciences, Inc.
- Sep 17, 20271.2yI-951LETROZOLELETROZOLEYiling Pharmaceutical Ltd
- Sep 17, 20271.2yI-950Kisqaliribociclib succinate$NVSNOVARTIS AG
- Sep 18, 20271.2ypatentAzelexazelaic acidAlmirall SA
- Sep 22, 20271.2yNCEOmlontiomidenepag isopropylOcuvex Therapeutics Inc
- Sep 26, 20271.2ypatentAPREPITANTAPREPITANT$HOTHHoth Therapeutics, Inc.
- Sep 26, 20271.2ypatentArgatrobanargatrobanMylan Institutional Inc
- Sep 27, 20271.2ypatentBetamethasone Dipropionate + Calcipotriene Perrigo(betamethasone dipropionate + calcipotriene)Perrigo New York Inc
- Sep 29, 20271.2yNCESODIUM PHENYLBUTYRATESODIUM PHENYLBUTYRATEHorizon Therapeutics USA Inc
- Sep 30, 20271.2yNCELytgobifutibatinibTaiho Oncology Inc
- Oct 3, 20271.2ypatentTymlosabaloparatideRadius Health Inc
- Oct 3, 20271.2ypatentOnpattropatisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Oct 4, 20271.2yD-194Ameluzaminolevulinic acid hydrochloride$BFRIBiofrontera Inc.
- Oct 5, 20271.2ypatentJuluca(dolutegravir sodium + rilpivirine hydrochloride)ViiV Healthcare Company
- Oct 5, 20271.2ypatentTivicaydolutegravir sodiumViiV Healthcare Company
- Oct 13, 20271.3ypatentImcivreesetmelanotide$RYTMRHYTHM PHARMACEUTICALS, INC.
- Oct 16, 20271.3yNPVyalev(foscarbidopa + foslevodopa)$ABBVAbbVie Inc.
- Oct 16, 20271.3ypatentLEVOCETIRIZINE DIHYDROCHLORIDELEVOCETIRIZINE DIHYDROCHLORIDEChattem Inc
- Oct 17, 20271.3ypatentLupkynisvoclosporin$AUPHAurinia Pharmaceuticals Inc.
- Oct 30, 20271.3yODE-327BronchitolmannitolArna Pharma Pty Ltd
- Nov 1, 20271.3yGAINTalicia(amoxicillin + omeprazole magnesium + rifabutin)$RDHLRedHill Biopharma Ltd.
- Nov 3, 20271.3ypatentRestasiscyclosporine$ABBVAbbVie Inc.
- Nov 16, 20271.4ypatentTopiramatetopiramateLP Pharmaceutical (Xiamen) Co Ltd
- Nov 19, 20271.4ypatentRukobiafostemsavir tromethamineViiV Healthcare Company
- Nov 19, 20271.4ypatentVarithenapolidocanolBTG International Inc
- Nov 20, 20271.4ypatentZykadiaceritinib$NVSNOVARTIS AG
- Nov 20, 20271.4yODE-324ZokinvylonafarnibSentynl Therapeutics Inc
- Nov 23, 20271.4yODE-339Oxlumolumasiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Nov 26, 20271.4yD-196ACETYLCYSTEINEACETYLCYSTEINEXellia Pharmaceuticals USA LLC
- Dec 1, 20271.4yNCERezlidhiaolutasidenib$RIGLRIGEL PHARMACEUTICALS INC
- Dec 1, 20271.4yODE-329Hetlioztasimelteon$VNDAVanda Pharmaceuticals Inc.
- Dec 3, 20271.4yNPOrladeyoberotralstat hydrochloride$BCRXBIOCRYST PHARMACEUTICALS INC
- Dec 3, 20271.4ypatentCefepime Hydrochloridecefepime hydrochlorideSamson Medical Technologies LLC
- Dec 10, 20271.4ypatentDeoxycholic Aciddeoxycholic acidSlayback Pharma LLC
- Dec 11, 20271.4ypatentAMBRISENTANAMBRISENTANSigmapharm Laboratories LLC
- Dec 11, 20271.4ypatentVALGANCICLOVIR HYDROCHLORIDEVALGANCICLOVIR HYDROCHLORIDENovadoz Pharmaceuticals LLC
- Dec 11, 20271.4ypatentXermelotelotristat ethylTerSera Therapeutics LLC
- Dec 12, 20271.4yNCEKrazatiadagrasibBristol-Myers Squibb Co
- Dec 12, 20271.4ypatentLodonalnaltrexone hydrochlorideBiostax Corp
- Dec 18, 20271.4ypatentTrelegy Ellipta(fluticasone furoate + umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Dec 18, 20271.4ypatentIncruse Elliptaumeclidinium bromideGlaxoSmithKline LLC
- Dec 18, 20271.4yI-955GemtesavibegronSumitomo Pharma America Inc
- Dec 19, 20271.4ypatentTobradex ST(dexamethasone + tobramycin)$HROWHARROW, INC.
- Dec 19, 20271.4yM-187Xofluzabaloxavir marboxil$SGIOFSHIONOGI & CO LTD
- Dec 19, 20271.4ypatentDoxycycline PrascodoxycyclinePrasco LLC
- Dec 20, 20271.4yM-270SkyclarysomaveloxoloneReata Pharmaceuticals Inc
- Dec 22, 20271.5yNCESunlencalenacapavir sodium$GILDGILEAD SCIENCES, INC.
- Dec 24, 20271.5ypatentNexavarsorafenib tosylateBayer HealthCare Pharmaceuticals Inc
- Dec 25, 20271.5ypatentFINGOLIMOD HYDROCHLORIDEFINGOLIMOD HYDROCHLORIDEEzra Ventures LLC
- Dec 28, 20271.5ypatentBOSENTANBOSENTAN$NSRXNasus Pharma Ltd
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)