the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 15, 2027186dpatentDuvyzatgivinostat hydrochlorideItalfarmaco SpA
- Jan 16, 2027187dpatentCamcevileuprolide mesylateForesee Pharmaceuticals Co Ltd
- Jan 18, 2027189dI-937Piqrayalpelisib$NVSNOVARTIS AG
- Jan 19, 2027190dpatentStiolto Respimat(olodaterol hydrochloride + tiotropium bromide)Boehringer Ingelheim Corp
- Jan 19, 2027190dI-930Balversaerdafitinib$JNJJOHNSON & JOHNSON
- Jan 19, 2027190dpatentStriverdi Respimatolodaterol hydrochlorideBoehringer Ingelheim Corp
- Jan 20, 2027191dpatentBendaviaelamipretide hydrochlorideStealth BioTherapeutics Inc
- Jan 22, 2027193dpatentActoplus Met(metformin hydrochloride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 23, 2027194dpatentVyxeos(cytarabine hydrochloride + daunorubicin hydrochloride)$JAZZJazz Pharmaceuticals plc
- Jan 23, 2027194dpatentAmitizalubiprostoneMallinckrodt LLC
- Jan 24, 2027195dODE-367DificidfidaxomicinCubist Pharmaceuticals LLC
- Jan 25, 2027196dpatentFentanylfentanylActavis Elizabeth LLC
- Jan 26, 2027197dpatentProcysbicysteamineHorizon Therapeutics USA Inc
- Jan 30, 2027201dpatentDuetact(glimepiride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 31, 2027202dpatentIlevronepafenac$HROWHARROW, INC.
- Feb 2, 2027204dpatentEPOPROSTENOL SODIUMEPOPROSTENOL SODIUMJanssen-Cilag Holdings Inc (Inactive)
- Feb 2, 2027204dpatentREGADENOSONREGADENOSONAPOTEX
- Feb 2, 2027204dpatentRayaldeecalcifediolOPKO Pharmaceuticals LLC
- Feb 7, 2027209dpatentPlan B One-SteplevonorgestrelFoundation Consumer Healthcare LLC
- Feb 9, 2027211dpatentavutometinib potassium$VSTMVerastem, Inc.
- Feb 12, 2027214dpatentRapivabperamivir$BCRXBIOCRYST PHARMACEUTICALS INC
- Feb 13, 2027215dNPAurlumyniloprostBTG International Inc
- Feb 16, 2027218dpatentEucrisacrisaborole$PFEPFIZER INC
- Feb 16, 2027218dI-941Tagrissoosimertinib mesylate$AZNASTRAZENECA PLC
- Feb 17, 2027219dNCEPyrukyndmitapivat sulfate$AGIOAGIOS PHARMACEUTICALS, INC.
- Feb 23, 2027225dI-942Biktarvy(bictegravir sodium + emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Feb 28, 2027230dpatentAdvil Allergy Sinus(chlorpheniramine maleate + ibuprofen + pseudoephedrine hydrochloride)$HLNHaleon plc
- Feb 28, 2027230dNCEVonjopacritinibSobi Inc
- Mar 4, 2027234dNPClobetasol Propionateclobetasol propionateTeva Pharmaceuticals USA Inc
- Mar 5, 2027235dpatentIbrancepalbociclib$OTLCOncotelic Therapeutics, Inc.
- Mar 7, 2027237dpatentMINOCYCLINE HYDROCHLORIDEMINOCYCLINE HYDROCHLORIDEThe Medicines Co
- Mar 10, 2027240dpatentDuavee(bazedoxifene acetate + conjugated estrogens)$PFEPFIZER INC
- Mar 11, 2027241dpatentZolinzavorinostat$MRKMerck & Co., Inc.
- Mar 15, 2027245dpatentDYANAVEL XR 20AMPHETAMINE$TRAWTraws Pharma, Inc.
- Mar 15, 2027245dpatentMETADATE ERMETHYLPHENIDATE HYDROCHLORIDELannett Co Inc
- Mar 15, 2027245dpatentTUZISTRA XRCHLORPHENIRAMINE POLISTIREX$TRAWTraws Pharma, Inc.
- Mar 15, 2027245dpatentDyanavel XRamfetamine [INN]Tris Pharma Inc
- Mar 15, 2027245dNPEdurant PEDrilpivirine hydrochloride$JNJJOHNSON & JOHNSON
- Mar 16, 2027246dpatentVanflytaquizartinib dihydrochlorideDaiichi Sankyo Co Ltd
- Mar 19, 2027249dpatentAlcaftadinealcaftadineFosun Pharma USA Inc
- Mar 20, 2027250dpatentSpravatoesketamine hydrochlorideJohnson & Johnson Innovative Medicine
- Mar 22, 2027252dI-943Nexlizet(bempedoic acid + ezetimibe)$ESPREsperion Therapeutics, Inc.
- Mar 22, 2027252dpatentDICLOFENAC SODIUMDICLOFENAC SODIUMAltaire Pharmaceuticals Inc
- Mar 22, 2027252dI-943Nexletolbempedoic acid$ESPREsperion Therapeutics, Inc.
- Mar 23, 2027253dpatentACYCLOVIRACYCLOVIRYiling Pharmaceutical Ltd
- Mar 23, 2027253dI-965Pluvictolutetium Lu 177 vipivotide tetraxetan$NVSNOVARTIS AG
- Mar 27, 2027257dpatentTRAZODONE HYDROCHLORIDETRAZODONE HYDROCHLORIDEAurolife Pharma LLC
- Mar 27, 2027257dpatentErleadaapalutamide [INN]$JNJJOHNSON & JOHNSON
- Apr 2, 2027263dI-939Fanaptiloperidone$VNDAVanda Pharmaceuticals Inc.
- Apr 4, 2027265dNPXromihydroxyureaNova Laboratories Ltd
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)