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  1. pharmadog
  2. ›drugs
  3. ›Amvuttra
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vutrisiran

Marketedupdated 3mo ago
by $ALNY ALNYLAM PHARMACEUTICALS, INC.
Approved
community read0 votes

all catalysts(0)

nothing on the calendar yet

Trials studying vutrisiran

  • phase3TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathyrecruitingn=125
  • phase3A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathyenrolling by invitationn=700
  • phase3HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathyactive not recruitingn=655
  • phase3HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)completedn=164

Patent cliff

source: FDA Orange Book
first barrier falls
Jun 13, 2027
304 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (13)

  • Jul 28, 2036compositionUS 10208307
  • Jul 28, 2036compositionUS 10683501
  • Jul 28, 2036compositionUS 11286486
  • Jul 28, 2036compositionUS 12049628
  • Aug 14, 2035compositionUS 10612024
  • Aug 14, 2035compositionUS 11401517
  • Nov 16, 2032compositionUS 10570391
  • Nov 16, 2032compositionUS 9399775
  • Dec 12, 2029compositionUS 81060223.3y
  • Dec 4, 2028compositionUS 108067912.3y
  • Dec 4, 2028compositionUS 88289562.3y
  • Dec 4, 2028compositionUS 93705812.3y
  • Aug 24, 2028compositionUS 101319072.0y

FDA exclusivities (3)

  • Jun 13, 2029ODE-212Orphan Drug (7y)2.8y
  • Mar 20, 2028I-964Indication (3y)1.6y
  • Jun 13, 2027NCENew Chemical Entity (5y)304d

News(10)

  • BridgeBio continues ATTR ascent as Alnylam’s Amvuttra falls short of expectations
    BridgeBio Pharma’s transthyretin amyloidosis medicine Attruby is off to a strong launch, while Alnylam lowered full-year sales guidance for competitor Amvuttra.
    biospace · 3h ago
  • 5 companies advancing ATTR assets in the wake of Wainua’s fail
    The Phase 3 failure of AstraZeneca and Ionis Pharmaceuticals’ antisense therapy in transthyretin amyloid cardiomyopathy last month left the space reeling—and readjusting. BioSpace looks at five con…
    biospace · 9d ago
  • Alnylam absorbs $10.8B blowback after cutting full-year guidance for TTR franchise
    Alnylam’s revenue cut “may create a near term credibility overhang and could “raise questions on peak sales potential, even if there’s tailwinds in the competitive landscape,” according to Stifel.
    biospace · 12d ago
  • Alnylam plunges as earnings deliver ‘one-two punch’
    The RNA-focused biotech shed 30% of its market value — or close to $12 billion — amid growing investor concerns about its main drug business.
    biopharma_dive · 12d ago
  • Alnylam cuts Amvuttra sales guidance as demand shifts, hurting stock
    Alnylam’s second-quarter earnings report Thursday did little to assuage investor concerns in what has already been a difficult year for the company. The drugmaker lowered its full-year sales projec…
    endpoints · 13d ago
  • Biotechs bring big launches and pharma rivalries into Q2 earnings period
    With the second quarter earnings period underway, BioSpace examines five biotechs with meaningful catalysts that analysts and investors are watching.
    biospace · 14d ago
  • Royalty Pharma pens $425M deal for slice of sales on AstraZeneca’s ATTR drug
    Royalty Pharma has secured a stake in another transthyretin-mediated amyloidosis drug, this time paying $125 million upfront to Neurimmune for a cut of the sales of its AstraZeneca-partnered med.
    fiercebiotech · 21d ago
  • AstraZeneca, Ionis drug fails big heart disease study in major setback
    Eplontersen’s failure in transthyretin-mediated amyloidosis cardiomyopathy caught Wall Street analysts by surprise and boosted the outlook of rival drugs from Alnylam and BridgeBio Pharma.
    biopharma_dive · 1mo ago
  • 10 clinical trials to watch in the second half of 2026
    The biotechnology sector’s upswing accelerated in the first half. Positive results from anticipated trials in lung cancer, Alzheimer’s and multiple autoimmune conditions could add to the momentum.
    biopharma_dive · 1mo ago
  • Pfizer deals extend patent life for a top-selling rare disease drug
    Settlements delaying the arrival of generic versions of tafamidis will protect billions in Pfizer revenue and have implications for others, including BridgeBio Pharma and Alnylam.
    biopharma_dive · 3mo ago
view all news mentions →
brand
Amvuttra
generic
vutrisiran
indication
Familial Amyloid Cardiomyopathy
phase
marketed
Data sources
ClinicalTrials.gov
last refreshed 1h ago
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