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  1. pharmadog
  2. ›drugs
  3. ›Amvuttra
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vutrisiran

Marketedupdated 5mo ago
by $ALNY ALNYLAM PHARMACEUTICALS, INC.
Approved
community read0 votes

all catalysts(0)

nothing on the calendar yet

Trials studying vutrisiran

  • phase3TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathyrecruitingn=125
  • phase3A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathyenrolling by invitationn=700
  • phase3HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathyactive not recruitingn=655
  • phase3HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)completedn=164

Patent cliff

source: FDA Orange Book
first barrier falls
Jun 13, 2027
256 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (13)

  • Jul 28, 2036compositionUS 10208307
  • Jul 28, 2036compositionUS 10683501
  • Jul 28, 2036compositionUS 11286486
  • Jul 28, 2036compositionUS 12049628
  • Aug 14, 2035compositionUS 10612024
  • Aug 14, 2035compositionUS 11401517
  • Nov 16, 2032compositionUS 10570391
  • Nov 16, 2032compositionUS 9399775
  • Dec 12, 2029compositionUS 81060223.2y
  • Dec 4, 2028compositionUS 108067912.2y
  • Dec 4, 2028compositionUS 88289562.2y
  • Dec 4, 2028compositionUS 93705812.2y
  • Aug 24, 2028compositionUS 101319071.9y

FDA exclusivities (3)

  • Jun 13, 2029ODE-212Orphan Drug (7y)2.7y
  • Mar 20, 2028I-964Indication (3y)1.5y
  • Jun 13, 2027NCENew Chemical Entity (5y)256d

News(10)

  • 5 biotechs braving the commercial waters with product launches
    A growing number of biotechs are entering the market with newly launched medicines, a pattern indicative of “improving capital markets,” according to Jefferies’ Andrew Tsai.
    biospace · 14d ago
  • ESC ‘26: Cytokinetics’ sell-off, Arrowhead’s edge and a heart drug autopsy
    At a big meeting for cardiovascular medicines, Cytokinetics and Arrowhead aimed to separate their drugs from competitors while a failed study pressured Alnylam.
    biopharma_dive · 29d ago
  • ESC: Alnylam's next-gen silencer sees silver linings after fallout of AZ, Ionis trial in ATTR-CM
    As AstraZeneca appears to close the book on a combo approach following the phase 3 failure of its Ionis-partnered Wainua, several analysts contend it’s too early to count out Alnylam’s silencing dr…
    fiercebiotech · 29d ago
  • STAT+: Alnylam defends heart disease drugs after failure of AstraZeneca’s Wainua
    An AstraZeneca heart disease trial failure has put Alnylam under pressure. It's mounting a defense of its medicines.
    stat · 1mo ago
  • ‘Worse than expected’ Wainua data muddies water for TTR silencers
    AstraZeneca and Ionis Pharmaceuticals’ data drop divulging more details from its highly watched Phase 3 transthyretin silencer trial “further confuses the picture” for Wainua when combined with the…
    biospace · 1mo ago
  • AstraZeneca, Ionis data spark debate about RNA drugs’ impact on deadly heart disease
    Results published in NEJM raised questions about the benefits “silencer” medications provide on top of standard therapies for TTR cardiomyopathy and amplified investor pressure on Alnylam.
    biopharma_dive · 1mo ago
  • What’s in Merck and Moderna’s cancer vaccine algorithm?
    A heart drug failure, RevMed's pancreatic cancer drug approved, and more biotech news from The Readout
    stat · 1mo ago
  • BridgeBio continues ATTR ascent as Alnylam’s Amvuttra falls short of expectations
    BridgeBio Pharma’s transthyretin amyloidosis medicine Attruby is off to a strong launch, while Alnylam lowered full-year sales guidance for competitor Amvuttra.
    biospace · 1mo ago
  • 5 companies advancing ATTR assets in the wake of Wainua’s fail
    The Phase 3 failure of AstraZeneca and Ionis Pharmaceuticals’ antisense therapy in transthyretin amyloid cardiomyopathy last month left the space reeling—and readjusting. BioSpace looks at five con…
    biospace · 1mo ago
  • Alnylam absorbs $10.8B blowback after cutting full-year guidance for TTR franchise
    Alnylam’s revenue cut “may create a near term credibility overhang and could “raise questions on peak sales potential, even if there’s tailwinds in the competitive landscape,” according to Stifel.
    biospace · 2mo ago
view all news mentions →
brand
Amvuttra
generic
vutrisiran
indication
Familial Amyloid Cardiomyopathy
phase
marketed
Data sources
ClinicalTrials.gov
last refreshed 3h ago
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