the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jan 9, 2027183dODE-356AyvakitavapritinibBlueprint Medicines Corp
- Jan 10, 2027184dNPPDIAZEPAMDIAZEPAMMylan Institutional Inc
- Jan 12, 2027186dpatentWinleviclascoteroneSun Pharmaceutical Industries Ltd
- Jan 14, 2027188dNCECibinqoabrocitinib$PFEPFIZER INC
- Jan 15, 2027189dpatentDuvyzatgivinostat hydrochlorideItalfarmaco SpA
- Jan 16, 2027190dpatentCamcevileuprolide mesylateForesee Pharmaceuticals Co Ltd
- Jan 18, 2027192dI-937Piqrayalpelisib$NVSNOVARTIS AG
- Jan 19, 2027193dpatentStiolto Respimat(olodaterol hydrochloride + tiotropium bromide)Boehringer Ingelheim Corp
- Jan 19, 2027193dI-930Balversaerdafitinib$JNJJOHNSON & JOHNSON
- Jan 19, 2027193dpatentStriverdi Respimatolodaterol hydrochlorideBoehringer Ingelheim Corp
- Jan 20, 2027194dpatentBendaviaelamipretide hydrochlorideStealth BioTherapeutics Inc
- Jan 22, 2027196dpatentActoplus Met(metformin hydrochloride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 23, 2027197dpatentVyxeos(cytarabine hydrochloride + daunorubicin hydrochloride)$JAZZJazz Pharmaceuticals plc
- Jan 23, 2027197dpatentAmitizalubiprostoneMallinckrodt LLC
- Jan 24, 2027198dODE-367DificidfidaxomicinCubist Pharmaceuticals LLC
- Jan 25, 2027199dpatentFentanylfentanylActavis Elizabeth LLC
- Jan 26, 2027200dpatentProcysbicysteamineHorizon Therapeutics USA Inc
- Jan 30, 2027204dpatentDuetact(glimepiride + pioglitazone hydrochloride)Takeda Pharmaceuticals USA Inc
- Jan 31, 2027205dpatentIlevronepafenac$HROWHARROW, INC.
- Feb 2, 2027207dpatentEPOPROSTENOL SODIUMEPOPROSTENOL SODIUMJanssen-Cilag Holdings Inc (Inactive)
- Feb 2, 2027207dpatentREGADENOSONREGADENOSONAPOTEX
- Feb 2, 2027207dpatentRayaldeecalcifediolOPKO Pharmaceuticals LLC
- Feb 7, 2027212dpatentPlan B One-SteplevonorgestrelFoundation Consumer Healthcare LLC
- Feb 9, 2027214dpatentavutometinib potassium$VSTMVerastem, Inc.
- Feb 12, 2027217dpatentRapivabperamivir$BCRXBIOCRYST PHARMACEUTICALS INC
- Feb 13, 2027218dNPAurlumyniloprostBTG International Inc
- Feb 16, 2027221dpatentEucrisacrisaborole$PFEPFIZER INC
- Feb 16, 2027221dI-941Tagrissoosimertinib mesylate$AZNASTRAZENECA PLC
- Feb 17, 2027222dNCEPyrukyndmitapivat sulfate$AGIOAGIOS PHARMACEUTICALS, INC.
- Feb 23, 2027228dI-942Biktarvy(bictegravir sodium + emtricitabine + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Feb 28, 2027233dpatentAdvil Allergy Sinus(chlorpheniramine maleate + ibuprofen + pseudoephedrine hydrochloride)$HLNHaleon plc
- Feb 28, 2027233dNCEVonjopacritinibSobi Inc
- Mar 4, 2027237dNPClobetasol Propionateclobetasol propionateTeva Pharmaceuticals USA Inc
- Mar 5, 2027238dpatentIbrancepalbociclib$OTLCOncotelic Therapeutics, Inc.
- Mar 7, 2027240dpatentMINOCYCLINE HYDROCHLORIDEMINOCYCLINE HYDROCHLORIDEThe Medicines Co
- Mar 10, 2027243dpatentDuavee(bazedoxifene acetate + conjugated estrogens)$PFEPFIZER INC
- Mar 11, 2027244dpatentZolinzavorinostat$MRKMerck & Co., Inc.
- Mar 15, 2027248dpatentDYANAVEL XR 20AMPHETAMINE$TRAWTraws Pharma, Inc.
- Mar 15, 2027248dpatentMETADATE ERMETHYLPHENIDATE HYDROCHLORIDELannett Co Inc
- Mar 15, 2027248dpatentTUZISTRA XRCHLORPHENIRAMINE POLISTIREX$TRAWTraws Pharma, Inc.
- Mar 15, 2027248dpatentDyanavel XRamfetamine [INN]Tris Pharma Inc
- Mar 15, 2027248dNPEdurant PEDrilpivirine hydrochloride$JNJJOHNSON & JOHNSON
- Mar 16, 2027249dpatentVanflytaquizartinib dihydrochlorideDaiichi Sankyo Co Ltd
- Mar 19, 2027252dpatentAlcaftadinealcaftadineFosun Pharma USA Inc
- Mar 20, 2027253dpatentSpravatoesketamine hydrochlorideJohnson & Johnson Innovative Medicine
- Mar 22, 2027255dI-943Nexlizet(bempedoic acid + ezetimibe)$ESPREsperion Therapeutics, Inc.
- Mar 22, 2027255dpatentDICLOFENAC SODIUMDICLOFENAC SODIUMAltaire Pharmaceuticals Inc
- Mar 22, 2027255dI-943Nexletolbempedoic acid$ESPREsperion Therapeutics, Inc.
- Mar 23, 2027256dpatentACYCLOVIRACYCLOVIRYiling Pharmaceutical Ltd
- Mar 23, 2027256dI-965Pluvictolutetium Lu 177 vipivotide tetraxetan$NVSNOVARTIS AG
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)