the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Mar 22, 2027188dI-943Nexlizet(bempedoic acid + ezetimibe)$ESPREsperion Therapeutics, Inc.
- Mar 22, 2027188dpatentDICLOFENAC SODIUMDICLOFENAC SODIUMAltaire Pharmaceuticals Inc
- Mar 22, 2027188dI-943Nexletolbempedoic acid$ESPREsperion Therapeutics, Inc.
- Mar 23, 2027189dpatentACYCLOVIRACYCLOVIRYiling Pharmaceutical Ltd
- Mar 23, 2027189dI-965Pluvictolutetium Lu 177 vipivotide tetraxetan$NVSNOVARTIS AG
- Mar 27, 2027193dpatentTRAZODONE HYDROCHLORIDETRAZODONE HYDROCHLORIDEAurolife Pharma LLC
- Mar 27, 2027193dpatentErleadaapalutamide [INN]$JNJJOHNSON & JOHNSON
- Apr 2, 2027199dI-939Fanaptiloperidone$VNDAVanda Pharmaceuticals Inc.
- Apr 4, 2027201dNPXromihydroxyureaNova Laboratories Ltd
- Apr 4, 2027201dpatentVarubirolapitant hydrochlorideTerSera Therapeutics LLC
- Apr 5, 2027202dNPPDovato(dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Apr 6, 2027203dpatentEdluarzolpidem tartrateMylan Specialty LP
- Apr 7, 2027204dM-200Quviviqdaridorexant hydrochlorideIdorsia Pharmaceutical Ltd
- Apr 10, 2027207dpatentSpiriva Handihalertiotropium bromideBoehringer Ingelheim Corp
- Apr 13, 2027210dpatentOXCARBAZEPINEOXCARBAZEPINEAucta Pharmaceuticals Inc
- Apr 15, 2027212dpatentTrijardy XR(empagliflozin + linagliptin + metformin hydrochloride)Boehringer Ingelheim Corp
- Apr 15, 2027212dpatentGlyxambi(empagliflozin + linagliptin)Boehringer Ingelheim Corp
- Apr 15, 2027212dNPJelmytomitomycin$URGNUroGen Pharma Ltd.
- Apr 17, 2027214dpatentClonidineclonidineDr. Reddy's Laboratories Ltd
- Apr 17, 2027214dODE-292Pemazyrepemigatinib$INCYINCYTE CORP
- Apr 17, 2027214dODE-309TukysatucatinibSeagen Inc
- Apr 18, 2027215dpatentNICARDIPINE HYDROCHLORIDENICARDIPINE HYDROCHLORIDE$AMRXAmneal Pharmaceuticals, Inc.
- Apr 18, 2027215dI-947AlecensaalectinibF. Hoffmann-La Roche Ltd
- Apr 23, 2027220dNPPLutatheralutetium Lu 177 dotatateAdvanced Accelerator Applications SA
- Apr 25, 2027222dpatentFOAMING HAND WASHCHLORHEXIDINE GLUCONATEXTTRIUM
- Apr 26, 2027223dGAINVivjoaoteseconazoleMycovia Pharmaceuticals Inc
- Apr 26, 2027223dNPRinvoq LQupadacitinib$ABBVAbbVie Inc.
- Apr 26, 2027223dI-946Rinvoqupadacitinib tartrate$ABBVAbbVie Inc.
- Apr 27, 2027224dpatentLENALIDOMIDELENALIDOMIDEBristol-Myers Squibb Co
- Apr 28, 2027225dNCECamzyosmavacamtenBristol-Myers Squibb Co
- May 2, 2027229dpatentTriamcinolone Acetonidetriamcinolone acetonideRising Pharma Holdings Inc
- May 3, 2027230dGAINVoquezna Triple Pakamoxicillin + clarithromycin + vonoprazan [INN]$PHATPhathom Pharmaceuticals, Inc.
- May 3, 2027230dGAINVoquezna Dual Pakamoxicillin + vonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- May 6, 2027233dODE-291Tabrectacapmatinib hydrochloride$NVSNOVARTIS AG
- May 8, 2027235dM-311RetevmoselpercatinibEli Lilly and Co
- May 12, 2027239dpatentXalkoricrizotinib$PFEPFIZER INC
- May 12, 2027239dpatentOngentysopicapone [INN]$AMRXAmneal Pharmaceuticals, Inc.
- May 14, 2027241dODE-296POMALIDOMIDEPOMALIDOMIDECelgene Corp
- May 14, 2027241dpatentTyvaso DPItreprostinil$UTHRUNITED THERAPEUTICS Corp
- May 15, 2027242dODE-298QinlockripretinibDeciphera Pharmaceuticals Inc
- May 16, 2027243dpatentGalafoldmigalastat hydrochloride$FOLDAMICUS THERAPEUTICS, INC.
- May 18, 2027245dpatentDoxepin Hydrochloridedoxepin hydrochlorideRK Pharma Inc
- May 22, 2027249dODE-300AlunbrigbrigatinibTakeda Pharmaceuticals USA Inc
- May 23, 2027250dI-956VtamatapinarofDermavant Sciences Inc
- May 24, 2027251dpatentKetorolac Tromethamineketorolac tromethamineApotex Corp
- May 26, 2027253dODE-290ARTESUNATEARTESUNATEArtasome Therapeutics LLC
- May 31, 2027258dpatentNexplanonetonogestrel$DAREDare Bioscience, Inc.
- May 31, 2027258dpatentAlfaicosapent ethylKD Pharma Group SA
- Jun 1, 2027259dpatentNORETHINDRONE ACETATE AND ETHINYL ESTRADIOL AND FERROUS FUMARATEETHINYL ESTRADIOLApotex Corp
- Jun 4, 2027262dpatentContrave(bupropion hydrochloride + naltrexone)Currax Pharmaceuticals LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)