the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- May 12, 2027193dpatentXalkoricrizotinib$PFEPFIZER INC
- May 12, 2027193dpatentOngentysopicapone [INN]$AMRXAmneal Pharmaceuticals, Inc.
- May 14, 2027195dODE-296POMALIDOMIDEPOMALIDOMIDECelgene Corp
- May 14, 2027195dpatentTyvaso DPItreprostinil$UTHRUNITED THERAPEUTICS Corp
- May 15, 2027196dODE-298QinlockripretinibDeciphera Pharmaceuticals Inc
- May 16, 2027197dpatentGalafoldmigalastat hydrochloride$FOLDAMICUS THERAPEUTICS, INC.
- May 18, 2027199dpatentDoxepin Hydrochloridedoxepin hydrochlorideRK Pharma Inc
- May 22, 2027203dODE-300AlunbrigbrigatinibTakeda Pharmaceuticals USA Inc
- May 23, 2027204dI-956VtamatapinarofDermavant Sciences Inc
- May 24, 2027205dpatentKetorolac Tromethamineketorolac tromethamineApotex Corp
- May 26, 2027207dODE-290ARTESUNATEARTESUNATEArtasome Therapeutics LLC
- May 29, 2027210dpatentMekinisttrametinib dimethyl sulfoxide$NVSNOVARTIS AG
- May 31, 2027212dpatentNexplanonetonogestrel$DAREDare Bioscience, Inc.
- May 31, 2027212dpatentAlfaicosapent ethylKD Pharma Group SA
- Jun 1, 2027213dpatentNORETHINDRONE ACETATE AND ETHINYL ESTRADIOL AND FERROUS FUMARATEETHINYL ESTRADIOLApotex Corp
- Jun 1, 2027213dpatentAcetaminophenacetaminophenGranules USA Inc
- Jun 4, 2027216dpatentContrave(bupropion hydrochloride + naltrexone)Currax Pharmaceuticals LLC
- Jun 7, 2027219dpatentFesoterodine Fumaratefesoterodine fumarateHetero USA Inc
- Jun 7, 2027219dD-192KlisyritirbanibulinAlmirall SA
- Jun 8, 2027220dpatentSafinamide Mesylatesafinamide mesylateZenara Pharma Pvt Ltd
- Jun 12, 2027224dNPPXigduo XR(dapagliflozin + metformin hydrochloride)AstraZeneca Pharmaceuticals LP
- Jun 13, 2027225dI-964Amvuttravutrisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Jun 14, 2027226dpatentAnoro Ellipta(umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Jun 15, 2027227dpatentCarbinoxamine Maleatecarbinoxamine maleateMission Pharmacal Co
- Jun 15, 2027227dI-977Zepzelcalurbinectedin$JAZZJazz Pharmaceuticals plc
- Jun 19, 2027231dpatentMorphine Sulfate Actavismorphine sulfateTeva Pharmaceuticals USA Inc
- Jun 19, 2027231dGAINBaxdeladelafloxacin meglumineMelinta Therapeutics LLC
- Jun 20, 2027232dpatentDAPAGLIFLOZINDAPAGLIFLOZINLupin Ltd
- Jun 21, 2027233dpatentOXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Jun 21, 2027233dNPPWakixpitolisant hydrochloride$HRMYHarmony Biosciences Holdings, Inc.
- Jun 22, 2027234dODE*Xpovioselinexor$KPTIKaryopharm Therapeutics Inc.
- Jun 25, 2027237dODE-312Finteplafenfluramine hydrochlorideUCB SA
- Jun 26, 2027238dODE-474Mycapssaoctreotide acetateChiasma Inc
- Jun 26, 2027238dpatentVafseovadadustat$AKBAAkebia Therapeutics, Inc.
- Jun 30, 2027242dpatentApretudecabotegravirViiV Healthcare Company
- Jun 30, 2027242dpatentFomepizolefomepizoleNavinta LLC
- Jun 30, 2027242dODE-311Dojolvitriheptanoin$RAREUltragenyx Pharmaceutical Inc.
- Jul 5, 2027247dpatentDesvenlafaxine Succinatedesvenlafaxine succinateIntellipharmaceutics Ltd
- Jul 7, 2027249dODE-316Inqovi(cedazuridine + decitabine)Otsuka Pharmaceutical Co Ltd
- Jul 10, 2027252dpatentByfavoremimazolam besylateAcacia Pharma Group Ltd
- Jul 11, 2027253dpatentSpinrazanusinersen$BIIBBIOGEN INC.
- Jul 14, 2027256dpatentInvokamet XR(canagliflozin + metformin hydrochloride)Johnson & Johnson Innovative Medicine
- Jul 14, 2027256dpatentCANAGLIFLOZINCANAGLIFLOZINJohnson & Johnson Innovative Medicine
- Jul 18, 2027260dpatentAdapaleneadapalenePL Developments Copiague LLC
- Jul 20, 2027262dpatentCalcium Acetatecalcium acetateNostrum Pharmaceuticals LLC
- Jul 21, 2027263dODE-361Xywavsodium oxybate$JAZZJazz Pharmaceuticals plc
- Jul 22, 2027264dNPMerzee(ethinylestradiol + norethindrone acetate)Wilshire Pharmaceuticals Inc
- Jul 23, 2027265dpatentBUPRENORPHINE HYDROCHLORIDEBUPRENORPHINE HYDROCHLORIDEBioDelivery Sciences International Inc
- Jul 23, 2027265dpatentFentorafentanyl citrateTeva Pharmaceuticals USA Inc
- Jul 23, 2027265dpatentTpoxxtecovirimat$NNVCNANOVIRICIDES, INC.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)