the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- May 29, 20358.6ypatentISOTRETINOINISOTRETINOINAmneal Pharmaceuticals of New York LLC
- Jun 26, 20358.7ypatentCyclophosphamidecyclophosphamide [INN]Long Grove Pharmaceuticals LLC
- Jul 9, 20358.7ypatentToprol-XLmetoprolol succinateMelinta Therapeutics LLC
- Oct 19, 20359.0ypatentVARENICLINE TARTRATEVARENICLINE TARTRATEOyster Point Pharma Inc
- Nov 6, 20359.0ypatentLisinoprillisinoprilCorePharma LLC
- Nov 13, 20359.0ypatentElixsure EXguaifenesinMoberg Pharma AB
- Dec 2, 20359.1ypatentArakodatafenoquine succinate$SXTP60 DEGREES PHARMACEUTICALS, INC.
- Jan 19, 20369.2ypatentTascenso ODTfingolimod [INN]Cycle Pharmaceuticals Ltd
- Feb 12, 20369.3ypatentRosuvastatin Calciumrosuvastatin calciumTeva Pharmaceuticals USA Inc
- Feb 16, 20369.3ypatentGvokeglucagon [INN]$XERSXeris Biopharma Holdings, Inc.
- Apr 21, 20369.5ypatentLansoprazolelansoprazoleNATCO Pharma Inc.
- Oct 11, 203610.0ypatentPROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDEDEXTROMETHORPHAN HYDROBROMIDEHetero Labs Ltd
- Oct 28, 203610.0ypatentCarospirspironolactone [INN]CMP Pharma Inc
- Dec 8, 203610.1ypatentEsomeprazole Magnesiumesomeprazole magnesiumGuangzhou Novaken Pharmaceutical Co Ltd
- Dec 8, 203610.1ypatentPrilosecomeprazoleCovis Pharmaceuticals Inc (Inactive)
- Dec 19, 203610.1ypatentCevirahexaminolevulinate hydrochlorideAsieris Pharmaceuticals (USA) Inc
- Dec 30, 203610.2ypatentAriceptdonepezil hydrochlorideEisai Co Ltd
- Jan 9, 203710.2ypatentSaxendaliraglutideNovo Nordisk Inc
- Feb 3, 203710.3ypatentRelexxiimethylphenidate hydrochlorideVertical Pharmaceuticals LLC
- Feb 7, 203710.3ypatentNumbrinococaine hydrochlorideCody Laboratories Inc
- Mar 7, 203710.4ypatentRedemploplozasiran sodium$ARWRARROWHEAD PHARMACEUTICALS, INC.
- Apr 13, 203710.5ypatentDuloxetine Hydrochlorideduloxetine hydrochlorideQingdao Baheal Medical Inc
- May 12, 203710.5ypatentPizensylactitol [INN]Sebela Pharmaceuticals Inc
- May 31, 203710.6ypatentThiotepathiotepa [INN]STI Pharma LLC
- Jun 7, 203710.6ypatentAtorvaliqatorvastatin calciumCMP Pharma Inc
- Jul 25, 203710.7ypatentCalcium Gluconatecalcium gluconateWG Critical Care LLC
- Aug 18, 203710.8ypatentPILOCARPINE HYDROCHLORIDEPILOCARPINE HYDROCHLORIDEInnogenix Inc
- Sep 8, 203710.9ypatentBACLOFENBACLOFENBeximco Pharmaceuticals USA Inc
- Dec 15, 203711.1ypatentMICAFUNGIN SODIUMMICAFUNGIN SODIUMXellia Pharmaceuticals USA LLC
- Dec 18, 203711.1ypatentHemadydexamethasone [INN]Fera Pharmaceuticals LLC
- Jan 24, 203811.2ypatentRanolazineranolazineLaurus Generics Inc
- Apr 16, 203811.5ypatentNimodipinenimodipine$GRCEGrace Therapeutics, Inc.
- Jun 18, 203811.6ypatentMestinonpyridostigmine bromideBausch Health US LLC
- Jul 10, 203811.7ypatentZurnainalmefenePurdue Pharma LP
- Aug 18, 203811.8ypatentZonisamidezonisamideGranules Pharma LLC
- Aug 22, 203811.8ypatentTretinoin MylantretinoinMylan Pharmaceuticals Inc
- Sep 15, 203811.9ypatentIheezochloroprocaine [INN]$HROWHARROW, INC.
- Oct 25, 203812.0ypatentPrevduo(glycopyrrolate + neostigmine methylsulfate)Par Pharmaceutical Inc
- Nov 5, 203812.0ypatentAlvaizeltrombopag [INN]Teva Pharmaceuticals USA Inc
- Nov 14, 203812.0ypatentThiolatiopronin [INN]Mission Pharmacal Co
- Nov 23, 203812.1ypatentCLADRIBINECLADRIBINEEMD Serono Inc
- Dec 24, 203812.2ypatentChewtadzytadalafil$ANIPANI PHARMACEUTICALS INC
- Jan 11, 203912.2ypatentFosaprepitant Dimegluminefosaprepitant dimeglumineAthenex Inc (Inactive)
- Feb 1, 203912.3ypatentAnnovera(ethinylestradiol [INN] + segesterone acetate)Mayne Pharma USA Inc
- Feb 27, 203912.3ypatentCombogesic(acetaminophen + ibuprofen sodium)Hikma Pharmaceuticals USA Inc
- Mar 7, 203912.4ypatentPOTASSIUM CHLORIDEPOTASSIUM CHLORIDEBelcher Pharmaceuticals LLC
- Mar 25, 203912.4ypatentAzmirotestosterone cypionateSlayback Pharma LLC
- Mar 25, 203912.4ypatentKhapzoryLEVOLEUCOVORINAcrotech Biopharma Inc
- Apr 19, 203912.5ypatentPotassium PhosphatesPOTASSIUM PHOSPHATESHospira Inc
- Jul 12, 203912.7ypatentIcotydeicotrokinra hydrochloride$JNJJOHNSON & JOHNSON
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)