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  1. pharmadog
  2. ›drugs
  3. ›Redemplo
drug · oligonucleotide
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plozasiran sodium

Marketedupdated 5mo ago
by $ARWR ARROWHEAD PHARMACEUTICALS, INC.🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 2
  • tagApproval4 co-mentions · 1 sources
  • drugREDEMPLO4 co-mentions · 1 sources

Oligonucleotide drug with a maximum clinical stage of Unknown (across all indications), with 3 investigational indications.

all catalysts(1)

approval · 1
Nov 18, 2025
approval
$ARWR64.19-0.93%
11mo ago
REDEMPLO (PLOZASIRAN SODIUM) — FDA approval
plozasiran sodium
→

Patent cliff

source: FDA Orange Book
first barrier falls
Mar 7, 2037
~10.4 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (5)

  • Sep 10, 2038compositionUS 10597657
  • Sep 10, 2038compositionUS 11214801
  • Sep 10, 2038compositionUS 12365899
  • Mar 7, 2037compositionUS 10294474
  • Mar 7, 2037compositionUS 11174481

News(7)

  • Arrowhead's new Redemplo findings in severe hypertriglyceridemia have analysts split
    Safety and dosing are likely to be “key differentiators” for Arrowhead Pharmaceuticals as it looks to challenge Ionis Pharmaceuticals’ lead in the severe hypertriglyceridemia market.
    biospace · 1mo ago
  • #ESC26: Arrowhead claims safety edge over Ionis as triglyceride battle draws closer
    MUNICH — Arrowhead is on course to crash Ionis Pharmaceuticals’ party. Arrowhead’s RNA interference drug Redemplo looked safer as well as effective in two late-stage trials in patients with high le…
    endpoints · 1mo ago
  • ‘Significant’ demand for Revolution drug; Intellia pinpoints liver toxicity culprit
    Early indicators from a compassionate use plan led analysts to hike projections for daraxonrasib. Elsewhere, Intellia believes it’s answered a key safety question and Arrowhead moved to catch a rival.
    biopharma_dive · 1mo ago
  • FDA panel confronting peptide controversy
    Today's biotech news features the FDA weighing the fate of peptides; approvals for RevMed, GSK; and data on Lilly's "triple-G."
    stat · 2mo ago
  • Arrowhead hits ‘best-case scenario’ with latest results for fat-lowering drug
    To analysts, the drug’s apparent safety and effects on both triglyceride levels and pancreatitis cases should make it competitive with a rival Ionis therapy.
    biopharma_dive · 2mo ago
  • Arrowhead’s gene silencer competitive with Ionis’ in triglyceride disease
    Arrowhead Pharmaceuticals’ lipid-lowering drug has hit in two late-stage trials that could expand its use into a much wider population. Data shared Wednesday showed that Arrowhead’s gene silencer R…
    endpoints · 2mo ago
  • Arrowhead puts pressure on Ionis with positive data for triglyceride lowering drug
    With Phase 3 data showing what analysts called a “potentially best-in-class profile,” Arrowhead Pharmaceuticals plans to submit for FDA approval of plozasiran by the end of the year—hoping to follo…
    biospace · 2mo ago
brand
Redemplo
generic
plozasiran sodium
MOA
12.1 Mechanism of Action Plozasiran is a siRNA conjugated with GalNAc that degrades the apoC-III mRNA through the RNA interference mechanism resulting in reduced levels of hepatic and serum apoC-III protein. Reduction of apoC- III protein leads to increased clearance of serum triglycerides.
indication
Hypertriglyceridemia
phase
marketed
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 2h ago
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