the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Dec 19, 20315.4yODE-515Tryngolzaolezarsen sodium$IONSIONIS PHARMACEUTICALS INC
- Jan 3, 20325.5ypatentTuxarin ER(chlorpheniramine maleate + codeine [INN])MainPointe Pharmaceuticals LLC
- Jan 4, 20325.5ypatentDEXMEDETOMIDINE HYDROCHLORIDEDEXMEDETOMIDINE HYDROCHLORIDEHQ Speciality Pharma
- Feb 10, 20325.6ypatentLokelmasodium zirconium cyclosilicateAstraZeneca Pharmaceuticals LP
- Mar 2, 20325.6ypatentNeoprofenibuprofen lysineRecordati Rare Diseases Inc
- Mar 9, 20325.7ypatentAscorascorbic acid [INN]Renovion Inc
- Mar 23, 20325.7ypatentOLINVYKOLICERIDINETrevena Inc
- Mar 23, 20325.7ypatentJornay PMmethylphenidate hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Apr 23, 20325.8ypatentHYDROMORPHONE HYDROCHLORIDEHYDROMORPHONE HYDROCHLORIDEFresenius Kabi USA LLC
- May 19, 20325.9ypatentPatadayolopatadine hydrochlorideAlcon Laboratories Inc
- Jun 22, 20326.0ypatentDefiteliodefibrotide sodium$JAZZJazz Pharmaceuticals plc
- Jun 28, 20326.0ypatentCotempla XR-ODTmethylphenidate hydrochloride$AYTUAYTU BIOPHARMA, INC
- Jun 29, 20326.0ypatentFirdapseamifampridine phosphate$CPRXCATALYST PHARMACEUTICALS, INC.
- Jul 27, 20326.0ypatentAzstarys(dexmethylphenidate hydrochloride + serdexmethylphenidate chloride)Corium LLC
- Aug 15, 20326.1ypatentOdefsey(emtricitabine + rilpivirine hydrochloride + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Aug 30, 20326.1ypatentDelstrigo(doravirine + lamivudine + tenofovir disoproxil fumarate)Merck Sharp & Dohme Corp (Inactive)
- Aug 30, 20326.1ypatentPifeltrodoravirineMerck Sharp & Dohme Corp (Inactive)
- Sep 27, 20326.2ypatentVizimprodacomitinib$PFEPFIZER INC
- Sep 29, 20326.2ypatentVazaloreaspirin [INN]$ASBPAspire Biopharma Holdings, Inc.
- Oct 21, 20326.3ypatentDawnzeradonidalorsen sodium$IONSIONIS PHARMACEUTICALS INC
- Oct 30, 20326.3ypatentXcopricenobamateSK Life Science Inc
- Nov 1, 20326.3ypatentSAPROPTERIN DIHYDROCHLORIDESAPROPTERIN DIHYDROCHLORIDE$RLFTYMindMaze Therapeutics Holding SA
- Nov 3, 20326.3ypatentBortezomibbortezomibHospira Inc
- Nov 6, 20326.3ypatentEnalapril Maleate Oceansideenalapril maleateOceanside Pharmaceuticals Inc
- Nov 19, 20326.4ypatentHYDROCORTISONEhydrocortisone$ETONEton Pharmaceuticals, Inc.
- Nov 21, 20326.4ypatentBijuva(estradiol [INN] + progesterone [INN])$DAREDare Bioscience, Inc.
- Dec 21, 20326.5ypatentCaspofungin Acetatecaspofungin acetateUnited Biomedical Inc
- Jan 2, 20336.5ypatentBUTALBITAL, ASPIRIN, CAFFEINE, AND CODEINE PHOSPHATEASPIRINNovitium Pharma LLC
- Jan 14, 20336.5ypatentComplera(emtricitabine + rilpivirine hydrochloride + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Jan 31, 20336.6ypatentNaftinnaftifine hydrochlorideLegacy Pharma Solutions
- Feb 18, 20336.6ypatentBonjesta(doxylamine [INN] + pyridoxine hydrochloride)Duchesnay USA Inc
- Feb 25, 20336.6ypatentNurtecrimegepant sulfate$PFEPFIZER INC
- Feb 28, 20336.6ypatentOrfadinnitisinoneSobi Inc
- Mar 15, 20336.7ypatentPhexxi(citric acid + potassium bitartrate)$EVFMEvofem Biosciences, Inc.
- Mar 15, 20336.7ypatentESMOLOL HYDROCHLORIDEESMOLOL HYDROCHLORIDEArkayli Biopharma Inc
- May 1, 20336.8ypatentEzetimibeezetimibeOEP Pharma
- May 31, 20336.9ypatentFENOFIBRATEFENOFIBRATEOrit Laboratories LLC
- Jul 25, 20337.0ypatentASENAPINEASENAPINESIGMAPHARM LABS LLC
- Sep 6, 20337.2ypatentLuzululiconazoleBausch Health US LLC
- Sep 20, 20337.2ypatentVumeritydiroximel fumarate$BIIBBIOGEN INC.
- Oct 6, 20337.2ypatentTorsemidetorsemideCorePharma LLC
- Oct 24, 20337.3ypatentXelstrymdextroamphetamineNoven Pharmaceuticals Inc
- Oct 29, 20337.3ypatentAuvelity(bupropion hydrochloride + dextromethorphan [INN])$AXSMAxsome Therapeutics, Inc.
- Nov 5, 20337.3ypatentVyleesibremelanotide acetate$PTNTPALATIN TECHNOLOGIES INC
- Nov 18, 20337.4ypatentDAPSONEDAPSONEPulmonem Inc
- Nov 25, 20337.4ypatentNatrobaspinosadParaPRO LLC
- Jan 6, 20347.5ypatentZegaloguedasiglucagonNovo Nordisk Inc
- Jan 8, 20347.5ypatentLoreev XRlorazepamAlmatica Pharma LLC
- Feb 14, 20347.6ypatentFULVESTRANTFULVESTRANTEagle Pharmaceuticals Inc
- Feb 17, 20347.6ypatentRIVAROXABANRIVAROXABANReddy US Therapeutics Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)