the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Sep 29, 20325.9ypatentVazaloreaspirin [INN]$ASBPAspire Biopharma Holdings, Inc.
- Oct 21, 20326.0ypatentDawnzeradonidalorsen sodium$IONSIONIS PHARMACEUTICALS INC
- Oct 30, 20326.0ypatentXcopricenobamateSK Life Science Inc
- Nov 1, 20326.0ypatentSAPROPTERIN DIHYDROCHLORIDESAPROPTERIN DIHYDROCHLORIDE$RLFTYMindMaze Therapeutics Holding SA
- Nov 3, 20326.0ypatentBortezomibbortezomibHospira Inc
- Nov 6, 20326.0ypatentEnalapril Maleate Oceansideenalapril maleateOceanside Pharmaceuticals Inc
- Nov 19, 20326.1ypatentHYDROCORTISONEhydrocortisone$ETONEton Pharmaceuticals, Inc.
- Nov 21, 20326.1ypatentBijuva(estradiol [INN] + progesterone [INN])$DAREDare Bioscience, Inc.
- Dec 21, 20326.1ypatentCaspofungin Acetatecaspofungin acetateUnited Biomedical Inc
- Jan 2, 20336.2ypatentBUTALBITAL, ASPIRIN, CAFFEINE, AND CODEINE PHOSPHATEASPIRINNovitium Pharma LLC
- Jan 14, 20336.2ypatentComplera(emtricitabine + rilpivirine hydrochloride + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Jan 20, 20336.2ypatentScenesseafamelanotide acetateClinuvel Pharmaceuticals Ltd
- Jan 31, 20336.3ypatentNaftinnaftifine hydrochlorideLegacy Pharma Solutions
- Feb 18, 20336.3ypatentBonjesta(doxylamine [INN] + pyridoxine hydrochloride)Duchesnay USA Inc
- Feb 25, 20336.3ypatentNurtecrimegepant sulfate$PFEPFIZER INC
- Feb 28, 20336.3ypatentOrfadinnitisinoneSobi Inc
- Mar 7, 20336.4ypatentOpfoldamiglustatBiocodex
- Mar 15, 20336.4ypatentPhexxi(citric acid + potassium bitartrate)$EVFMEvofem Biosciences, Inc.
- Mar 15, 20336.4ypatentESMOLOL HYDROCHLORIDEESMOLOL HYDROCHLORIDEArkayli Biopharma Inc
- May 1, 20336.5ypatentEzetimibeezetimibeOEP Pharma
- May 3, 20336.5ypatentInveltysloteprednol etabonate$ALCALCON INC
- May 31, 20336.6ypatentFENOFIBRATEFENOFIBRATEOrit Laboratories LLC
- Jul 25, 20336.7ypatentASENAPINEASENAPINESIGMAPHARM LABS LLC
- Sep 6, 20336.9ypatentLuzululiconazoleBausch Health US LLC
- Sep 20, 20336.9ypatentVumeritydiroximel fumarate$BIIBBIOGEN INC.
- Oct 6, 20336.9ypatentTorsemidetorsemideCorePharma LLC
- Oct 24, 20337.0ypatentXelstrymdextroamphetamineNoven Pharmaceuticals Inc
- Oct 29, 20337.0ypatentAuvelity(bupropion hydrochloride + dextromethorphan [INN])$AXSMAxsome Therapeutics, Inc.
- Nov 5, 20337.0ypatentVyleesibremelanotide acetate$PTNTPALATIN TECHNOLOGIES INC
- Nov 18, 20337.1ypatentDAPSONEDAPSONEPulmonem Inc
- Nov 25, 20337.1ypatentNatrobaspinosadParaPRO LLC
- Jan 6, 20347.2ypatentZegaloguedasiglucagonNovo Nordisk Inc
- Jan 8, 20347.2ypatentLoreev XRlorazepamAlmatica Pharma LLC
- Jan 31, 20347.3ypatentRyzumviphentolamine mesylate$IRDOpus Genetics, Inc.
- Feb 14, 20347.3ypatentFULVESTRANTFULVESTRANTEagle Pharmaceuticals Inc
- Feb 17, 20347.3ypatentRIVAROXABANRIVAROXABANReddy US Therapeutics Inc
- Mar 13, 20347.4ypatentIVERMECTINIVERMECTINMountain Valley MD Holdings Inc
- Mar 17, 20347.4ypatentYonsaabiraterone acetateSun Pharmaceutical Industries Ltd
- Apr 3, 20347.4ypatentFurosemidefurosemideSun Pharmaceutical Industries Ltd
- Jul 30, 20347.7ypatentRizatriptan Benzoaterizatriptan benzoateBionpharma Inc
- Sep 2, 20347.8ypatentZirganganciclovir$BLCOBausch & Lomb Corp
- Sep 4, 20347.8ypatentRyaltris(mometasone furoate + olopatadine hydrochloride)Hikma Pharmaceuticals USA Inc
- Nov 21, 20348.1ypatentDEFERASIROXDEFERASIROXReddy US Therapeutics Inc
- Jan 30, 20358.3ypatentVasostrictvasopressinPar Pharmaceutical Inc
- Feb 25, 20358.3ypatentBrynovinsitagliptinRevio Therapeutics LLP
- Feb 26, 20358.3ypatentNOREPINEPHRINE BITARTRATENOREPINEPHRINE BITARTRATEInforlife SA
- Feb 27, 20358.3ypatentBafiertammonomethyl fumarateCycle Pharmaceuticals Ltd
- Mar 13, 20358.4ypatentVancomycin Hydrochloridevancomycin hydrochlorideSamson Medical Technologies LLC
- Mar 26, 20358.4ypatentPemfexypemetrexed [INN]Eagle Pharmaceuticals Inc
- Apr 21, 20358.5ypatenthydrogen peroxideKortuc Japan LLC
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)