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  1. pharmadog
  2. ›drugs
  3. ›Ryzumvi
drug · small molecule
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phentolamine mesylate

Marketedupdated 3mo ago
by $IRD Opus Genetics, Inc.🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • drugMR-1424 co-mentions · 1 sources
  • drugphentolamine4 co-mentions · 1 sources
  • tagRecall2 co-mentions · 1 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for adrenal gland pheochromocytoma and 2 investigational indications.

indications

investigational
Hypertension

targets

Adrenergic receptor alpha

all catalysts(0)

nothing on the calendar yet

Trials studying phentolamine mesylate

  • phase2Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbancescompletedn=24
  • phase2Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucomacompletedn=39
  • phase2Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasiscompletedn=32

Patent cliff

source: FDA Orange Book
first barrier falls
Sep 25, 2026
35 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (9)

  • Dec 25, 2039method-of-use (U-3804)US 12201615
  • Oct 25, 2039method-of-use (U-3804)US 11400077
  • Oct 25, 2039method-of-use (U-3804)US 12201616
  • Jan 31, 2034formulationUS 10278918
  • Jan 31, 2034formulationUS 10772829
  • Jan 31, 2034formulationUS 11090261
  • Jan 31, 2034formulationUS 11844858
  • Jan 31, 2034formulationUS 12350366
  • Jan 31, 2034formulationUS 9795560

FDA exclusivities (1)

  • Sep 25, 2026NPNP35d

News(0)

no news has mentioned this drug yet

brand
Ryzumvi
trade names
Oraverse, Phentolamine mesylate, Regitine, Rogitine, Ryzumvi
generic
phentolamine mesylate
MOA
Adrenergic receptor alpha antagonist
indication
Presbyopia
phase
marketed
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 5m ago
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