the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Mar 23, 20325.5ypatentJornay PMmethylphenidate hydrochloride$COLLCOLLEGIUM PHARMACEUTICAL, INC
- Apr 23, 20325.6ypatentHYDROMORPHONE HYDROCHLORIDEHYDROMORPHONE HYDROCHLORIDEFresenius Kabi USA LLC
- May 10, 20325.7ypatentTemsirolimustemsirolimusAccord Healthcare Inc
- May 19, 20325.7ypatentPatadayolopatadine hydrochlorideAlcon Laboratories Inc
- Jun 22, 20325.8ypatentDefiteliodefibrotide sodium$JAZZJazz Pharmaceuticals plc
- Jun 28, 20325.8ypatentCotempla XR-ODTmethylphenidate hydrochloride$AYTUAYTU BIOPHARMA, INC
- Jun 29, 20325.8ypatentFirdapseamifampridine phosphate$CPRXCATALYST PHARMACEUTICALS, INC.
- Jul 27, 20325.9ypatentAzstarys(dexmethylphenidate hydrochloride + serdexmethylphenidate chloride)Corium LLC
- Aug 15, 20325.9ypatentOdefsey(emtricitabine + rilpivirine hydrochloride + tenofovir alafenamide)$GILDGILEAD SCIENCES, INC.
- Aug 30, 20326.0ypatentDelstrigo(doravirine + lamivudine + tenofovir disoproxil fumarate)Merck Sharp & Dohme Corp (Inactive)
- Aug 30, 20326.0ypatentPifeltrodoravirineMerck Sharp & Dohme Corp (Inactive)
- Sep 27, 20326.0ypatentVizimprodacomitinib$PFEPFIZER INC
- Sep 29, 20326.0ypatentVazaloreaspirin [INN]$ASBPAspire Biopharma Holdings, Inc.
- Oct 21, 20326.1ypatentDawnzeradonidalorsen sodium$IONSIONIS PHARMACEUTICALS INC
- Oct 30, 20326.1ypatentXcopricenobamateSK Life Science Inc
- Nov 1, 20326.1ypatentSAPROPTERIN DIHYDROCHLORIDESAPROPTERIN DIHYDROCHLORIDE$RLFTYMindMaze Therapeutics Holding SA
- Nov 3, 20326.1ypatentBortezomibbortezomibHospira Inc
- Nov 6, 20326.1ypatentEnalapril Maleate Oceansideenalapril maleateOceanside Pharmaceuticals Inc
- Nov 19, 20326.2ypatentHYDROCORTISONEhydrocortisone$ETONEton Pharmaceuticals, Inc.
- Nov 21, 20326.2ypatentBijuva(estradiol [INN] + progesterone [INN])$DAREDare Bioscience, Inc.
- Dec 21, 20326.3ypatentCaspofungin Acetatecaspofungin acetateUnited Biomedical Inc
- Jan 2, 20336.3ypatentBUTALBITAL, ASPIRIN, CAFFEINE, AND CODEINE PHOSPHATEASPIRINNovitium Pharma LLC
- Jan 14, 20336.3ypatentComplera(emtricitabine + rilpivirine hydrochloride + tenofovir disoproxil fumarate)$GILDGILEAD SCIENCES, INC.
- Jan 31, 20336.4ypatentNaftinnaftifine hydrochlorideLegacy Pharma Solutions
- Feb 18, 20336.4ypatentBonjesta(doxylamine [INN] + pyridoxine hydrochloride)Duchesnay USA Inc
- Feb 25, 20336.5ypatentNurtecrimegepant sulfate$PFEPFIZER INC
- Feb 28, 20336.5ypatentOrfadinnitisinoneSobi Inc
- Mar 15, 20336.5ypatentPhexxi(citric acid + potassium bitartrate)$EVFMEvofem Biosciences, Inc.
- Mar 15, 20336.5ypatentESMOLOL HYDROCHLORIDEESMOLOL HYDROCHLORIDEArkayli Biopharma Inc
- May 1, 20336.6ypatentEzetimibeezetimibeOEP Pharma
- May 3, 20336.6ypatentInveltysloteprednol etabonate$ALCALCON INC
- May 31, 20336.7ypatentFENOFIBRATEFENOFIBRATEOrit Laboratories LLC
- Jul 25, 20336.9ypatentASENAPINEASENAPINESIGMAPHARM LABS LLC
- Sep 6, 20337.0ypatentLuzululiconazoleBausch Health US LLC
- Sep 20, 20337.0ypatentVumeritydiroximel fumarate$BIIBBIOGEN INC.
- Oct 6, 20337.1ypatentTorsemidetorsemideCorePharma LLC
- Oct 24, 20337.1ypatentXelstrymdextroamphetamineNoven Pharmaceuticals Inc
- Oct 29, 20337.1ypatentAuvelity(bupropion hydrochloride + dextromethorphan [INN])$AXSMAxsome Therapeutics, Inc.
- Nov 5, 20337.1ypatentVyleesibremelanotide acetate$PTNTPALATIN TECHNOLOGIES INC
- Nov 18, 20337.2ypatentDAPSONEDAPSONEPulmonem Inc
- Nov 25, 20337.2ypatentNatrobaspinosadParaPRO LLC
- Jan 6, 20347.3ypatentZegaloguedasiglucagonNovo Nordisk Inc
- Jan 8, 20347.3ypatentLoreev XRlorazepamAlmatica Pharma LLC
- Feb 14, 20347.4ypatentFULVESTRANTFULVESTRANTEagle Pharmaceuticals Inc
- Feb 17, 20347.4ypatentRIVAROXABANRIVAROXABANReddy US Therapeutics Inc
- Mar 13, 20347.5ypatentIVERMECTINIVERMECTINMountain Valley MD Holdings Inc
- Mar 17, 20347.5ypatentYonsaabiraterone acetateSun Pharmaceutical Industries Ltd
- Apr 3, 20347.6ypatentFurosemidefurosemideSun Pharmaceutical Industries Ltd
- Jul 30, 20347.9ypatentRizatriptan Benzoaterizatriptan benzoateBionpharma Inc
- Sep 2, 20348.0ypatentZirganganciclovir$BLCOBausch & Lomb Corp
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)