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About 70,000 Americans died of drug overdoses last year — about 14% fewer than the previous year, according to preliminary government data.

Marty Makary's resignation leaves the agency with temporary directors in three top positions, and a number of newly instituted policies with an unclear future.

A pair of trial results published in medical journals suggest switching from high-dose injectables to lower doses or pills could help people with obesity keep their weight down over the long term.