the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Apr 4, 2027265dpatentVarubirolapitant hydrochlorideTerSera Therapeutics LLC
- Apr 5, 2027266dNPPDovato(dolutegravir sodium + lamivudine)ViiV Healthcare Company
- Apr 6, 2027267dpatentEdluarzolpidem tartrateMylan Specialty LP
- Apr 7, 2027268dM-200Quviviqdaridorexant hydrochlorideIdorsia Pharmaceutical Ltd
- Apr 13, 2027274dpatentOXCARBAZEPINEOXCARBAZEPINEAucta Pharmaceuticals Inc
- Apr 15, 2027276dpatentTrijardy XR(empagliflozin + linagliptin + metformin hydrochloride)Boehringer Ingelheim Corp
- Apr 15, 2027276dpatentGlyxambi(empagliflozin + linagliptin)Boehringer Ingelheim Corp
- Apr 17, 2027278dpatentClonidineclonidineDr. Reddy's Laboratories Ltd
- Apr 17, 2027278dODE-292Pemazyrepemigatinib$INCYINCYTE CORP
- Apr 17, 2027278dODE-309TukysatucatinibSeagen Inc
- Apr 18, 2027279dpatentNICARDIPINE HYDROCHLORIDENICARDIPINE HYDROCHLORIDE$AMRXAmneal Pharmaceuticals, Inc.
- Apr 18, 2027279dI-947AlecensaalectinibF. Hoffmann-La Roche Ltd
- Apr 23, 2027284dNPPLutatheralutetium Lu 177 dotatateAdvanced Accelerator Applications SA
- Apr 25, 2027286dpatentFOAMING HAND WASHCHLORHEXIDINE GLUCONATEXTTRIUM
- Apr 26, 2027287dGAINVivjoaoteseconazoleMycovia Pharmaceuticals Inc
- Apr 26, 2027287dNPRinvoq LQupadacitinib$ABBVAbbVie Inc.
- Apr 26, 2027287dI-946Rinvoqupadacitinib tartrate$ABBVAbbVie Inc.
- Apr 27, 2027288dpatentLENALIDOMIDELENALIDOMIDEBristol-Myers Squibb Co
- Apr 28, 2027289dNCECamzyosmavacamtenBristol-Myers Squibb Co
- May 2, 2027293dpatentTriamcinolone Acetonidetriamcinolone acetonideRising Pharma Holdings Inc
- May 3, 2027294dGAINVoquezna Triple Pakamoxicillin + clarithromycin + vonoprazan [INN]$PHATPhathom Pharmaceuticals, Inc.
- May 3, 2027294dGAINVoquezna Dual Pakamoxicillin + vonoprazan fumarate$PHATPhathom Pharmaceuticals, Inc.
- May 6, 2027297dODE-291Tabrectacapmatinib hydrochloride$NVSNOVARTIS AG
- May 8, 2027299dM-311RetevmoselpercatinibEli Lilly and Co
- May 12, 2027303dpatentXalkoricrizotinib$PFEPFIZER INC
- May 14, 2027305dpatentTyvaso DPItreprostinil$UTHRUNITED THERAPEUTICS Corp
- May 15, 2027306dODE-298QinlockripretinibDeciphera Pharmaceuticals Inc
- May 16, 2027307dpatentGalafoldmigalastat hydrochloride$FOLDAMICUS THERAPEUTICS, INC.
- May 18, 2027309dpatentDoxepin Hydrochloridedoxepin hydrochlorideRK Pharma Inc
- May 22, 2027313dODE-300AlunbrigbrigatinibTakeda Pharmaceuticals USA Inc
- May 23, 2027314dI-956VtamatapinarofDermavant Sciences Inc
- May 24, 2027315dpatentKetorolac Tromethamineketorolac tromethamineApotex Corp
- May 26, 2027317dODE-290ARTESUNATEARTESUNATEArtasome Therapeutics LLC
- May 31, 2027322dpatentAlfaicosapent ethylKD Pharma Group SA
- Jun 1, 2027323dpatentNORETHINDRONE ACETATE AND ETHINYL ESTRADIOL AND FERROUS FUMARATEETHINYL ESTRADIOLApotex Corp
- Jun 4, 2027326dpatentContrave(bupropion hydrochloride + naltrexone)Currax Pharmaceuticals LLC
- Jun 7, 2027329dpatentFesoterodine Fumaratefesoterodine fumarateHetero USA Inc
- Jun 7, 2027329dD-192KlisyritirbanibulinAlmirall SA
- Jun 8, 2027330dpatentSafinamide Mesylatesafinamide mesylateZenara Pharma Pvt Ltd
- Jun 12, 2027334dNPPXigduo XR(dapagliflozin + metformin hydrochloride)AstraZeneca Pharmaceuticals LP
- Jun 13, 2027335dI-964Amvuttravutrisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Jun 14, 2027336dpatentAnoro Ellipta(umeclidinium bromide + vilanterol trifenatate)GlaxoSmithKline LLC
- Jun 15, 2027337dpatentCarbinoxamine Maleatecarbinoxamine maleateMission Pharmacal Co
- Jun 15, 2027337dI-977Zepzelcalurbinectedin$JAZZJazz Pharmaceuticals plc
- Jun 19, 2027341dpatentMorphine Sulfate Actavismorphine sulfateTeva Pharmaceuticals USA Inc
- Jun 20, 2027342dpatentDAPAGLIFLOZINDAPAGLIFLOZINLupin Ltd
- Jun 21, 2027343dpatentOXYMORPHONE HYDROCHLORIDEOXYMORPHONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Jun 22, 2027344dODE*Xpovioselinexor$KPTIKaryopharm Therapeutics Inc.
- Jun 25, 2027347dODE-312Finteplafenfluramine hydrochlorideUCB SA
- Jun 26, 2027348dpatentVafseovadadustat$AKBAAkebia Therapeutics, Inc.
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)