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  1. pharmadog
  2. ›drugs
  3. ›Epidiolex
drug · small molecule
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cannabidiol

Marketedupdated 3mo ago
by $JAZZ Jazz Pharmaceuticals plc🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • companyUniversity of Colorado Denver1 co-mentions · 1 sources
  • companyJohns Hopkins University1 co-mentions · 1 sources
  • tagPain1 co-mentions · 1 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 5 approved and 82 investigational indications.

indications

investigational
EpilepsySchizophrenia

targets

Cannabinoid receptor 1

all catalysts(0)

nothing on the calendar yet

Trials studying cannabidiol

  • phase4Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solutionactive not recruitingn=154
  • phase3Cannabidiol in Patients With COVID-19 and Cardiovascular Disease or Risk Factorsterminatedn=90
  • phase2Unique Treatment of Oncology Pain in Advanced Cancercompletedn=11
  • —Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancyrecruitingn=50
  • phase2Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritisterminatedn=20
  • phase4A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolexnot yet recruitingn=25
  • phase4A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complexactive not recruitingn=79
  • phase3Stratification and Treatment in Early Psychosis Study - PROMOTEnot yet recruitingn=586
more trials →

Patent cliff

source: FDA Orange Book
first barrier falls
Oct 20, 2026
62 days

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (32)

  • Mar 1, 2041method-of-use (U-3233)US 11160795
  • Mar 1, 2041method-of-use (U-3233)US 11406623
  • Mar 1, 2041method-of-use (U-3233)US 12102619
  • Apr 26, 2039compositionUS 11207292
  • Apr 26, 2039compositionUS 11865102
  • Oct 13, 2035method-of-use (U-3073)US 10918608
  • Oct 13, 2035method-of-use (U-3071)US 11065209
  • Oct 13, 2035compositionUS 11096905
  • Oct 13, 2035method-of-use (U-3071)US 11400055
  • Jun 17, 2035method-of-use (U-2427)US 10092525
  • Jun 17, 2035method-of-use (U-2442)US 10111840
  • Jun 17, 2035method-of-use (U-2455)US 10137095
  • Jun 17, 2035method-of-use (U-2783)US 10603288
  • Jun 17, 2035method-of-use (U-2862)US 10709671
  • Jun 17, 2035formulationUS 10709673
  • Jun 17, 2035method-of-use (U-2780)US 10709674
  • Jun 17, 2035method-of-use (U-2454)US 10849860
  • Jun 17, 2035formulationUS 10966939
  • Jun 17, 2035method-of-use (U-3236)US 11154516
  • Jun 17, 2035method-of-use (U-3376)US 11311498
  • Jun 17, 2035method-of-use (U-2862)US 11357741
  • Jun 17, 2035method-of-use (U-3071)US 11446258
  • Jun 17, 2035formulationUS 11633369
  • Jun 17, 2035method-of-use (U-2781)US 11701330
  • Jun 17, 2035method-of-use (U-2781)US 11766411
  • Jun 17, 2035method-of-use (U-2781)US 11963937
  • Jun 17, 2035method-of-use (U-3989)US 12064399
  • Jun 17, 2035method-of-use (U-2421)US 9949937
  • Jun 17, 2035method-of-use (U-2423)US 9956183
  • Jun 17, 2035method-of-use (U-2424)US 9956184
  • Jun 17, 2035method-of-use (U-2425)US 9956185
  • Jun 17, 2035method-of-use (U-2426)US 9956186

FDA exclusivities (3)

  • Jul 31, 2027ODE-326Orphan Drug (7y)346d
  • Jul 31, 2027ODE-332Orphan Drug (7y)346d
  • Oct 20, 2026M-270Method (3y)62d

News(3)

  • Jazz to buy rare epilepsy drugmaker in potentially $1.3B deal
    Actio Biosciences, which will receive $820 million up front in the deal, adds to a major upswing in private biotech buyouts seen throughout this year.
    biopharma_dive · 7d ago
  • Jazz commits up to $1.3B to buy Actio, bolster epilepsy pipeline
    Jazz Pharmaceuticals is reaching into its wallet once again, this time buying Actio Biosciences and an experimental therapy for KCNT1+ epilepsy, a form of the disease with no FDA-approved treatments.
    biospace · 7d ago
  • Jazz pays $820M to buy Actio, adding clinical-stage asset to orchestra of epilepsy therapies
    Jazz Pharmaceuticals is adding to its orchestra of epilepsy treatments with the acquisition of Actio Biosciences for $820 million upfront.
    fiercebiotech · 8d ago
brand
Epidiolex
trade names
Epidiolex, Epidyolex
generic
cannabidiol
MOA
Cannabinoid CB1 receptor negative allosteric modulator
indication
Infantile Spasm (West Syndrome)
phase
marketed
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 13m ago
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