the cliff
Patent cliff
Drugs ranked by the soonest barrier to generic / biosimilar entry. Each row shows the earliest-expiring patent OR FDA exclusivity for that drug — whichever falls first determines when competitive pressure begins.
- Jul 23, 2027265dpatentVardenafil Hydrochloridevardenafil hydrochlorideMacleods Pharma USA Inc
- Jul 24, 2027266dpatentLialdamesalamineTakeda Pharmaceuticals USA Inc
- Jul 28, 2027270dpatentDopteletavatrombopag maleateSwedish Orphan Biovitrum AB
- Jul 31, 2027273dODE-326Epidiolexcannabidiol$JAZZJazz Pharmaceuticals plc
- Aug 1, 2027274dpatentSalonpasmethyl salicylate [INN]Hisamitsu America Inc
- Aug 1, 2027274dpatentELTROMBOPAG OLAMINEELTROMBOPAG OLAMINE$AMRXAmneal Pharmaceuticals, Inc.
- Aug 3, 2027276dpatentRelistormethylnaltrexone bromideSalix Pharmaceuticals Ltd
- Aug 3, 2027276dpatentPrednisoneprednisone [INN]Vintage Pharmaceuticals Inc (Inactive)
- Aug 5, 2027278dODE-315MAGNESIUM SULFATEMAGNESIUM SULFATEMilla Pharmaceuticals Inc
- Aug 6, 2027279dpatentNinlaroixazomib citrateMillennium Pharmaceuticals Inc
- Aug 6, 2027279dODE-319Lampitnifurtimox [INN]Bayer HealthCare Pharmaceuticals Inc
- Aug 7, 2027280dNPDhivy(carbidopa + levodopa)Avion Pharmaceuticals LLC
- Aug 7, 2027280dODE-334EVRYSDIRISDIPLAMGenentech Inc
- Aug 7, 2027280dI-949Fabhaltaiptacopan hydrochloride$NVSNOVARTIS AG
- Aug 12, 2027285dpatentAkeega(abiraterone acetate + niraparib)$JNJJOHNSON & JOHNSON
- Aug 12, 2027285dpatentIluvienfluocinolone acetonideAlimera Sciences Inc
- Aug 12, 2027285dpatentRubracarucaparib camsylatepharmaand GmbH
- Aug 12, 2027285dODE-280ViltepsoviltolarsenNS Pharma Inc
- Aug 13, 2027286dpatentDesonide ActavisdesonideTeva Pharmaceuticals USA Inc
- Aug 17, 2027290dpatentXuridenuridine triacetateBTG International Inc
- Aug 19, 2027292dpatentJuxtapidlomitapideChiesi USA Inc
- Aug 20, 2027293dpatentFibricorcholine fenofibrateAthena Bioscience LLC
- Aug 24, 2027297dpatentOXYCODONE HYDROCHLORIDEOXYCODONE HYDROCHLORIDE$AVTRAvantor, Inc.
- Aug 24, 2027297dpatentHysingla ERhydrocodone bitartratePurdue Pharma LP
- Aug 29, 2027302dGAINVabomere(meropenem + vaborbactam)A. Menarini Industrie Farmaceutiche Riunite Srl
- Aug 30, 2027303dNPPrevymisletermovirMerck Sharp & Dohme Corp (Inactive)
- Aug 30, 2027303dM-309Zeposiaozanimod hydrochlorideCelgene Corp
- Sep 1, 2027305dODE-320OnuregazacitidineBristol-Myers Squibb Co
- Sep 1, 2027305dpatentNeuprorotigotineUCB SA
- Sep 2, 2027306dpatentXifaxanrifaximinSalix Pharmaceuticals Ltd
- Sep 3, 2027307dpatentLEVETIRACETAMLEVETIRACETAMUCB SA
- Sep 4, 2027308dODE-318Gavretopralsetinib [INN]Blueprint Medicines Corp
- Sep 5, 2027309dpatentNourianzistradefyllineKyowa Hakko USA Inc
- Sep 9, 2027313dNCESotyktudeucravacitinibBristol-Myers Squibb Co
- Sep 13, 2027317dM-308Qsymia(phentermine hydrochloride + topiramate)Vivus LLC
- Sep 14, 2027318dNCETerlivazterlipressin$BIVIBIOVIE INC.
- Sep 15, 2027319dGAINSolosecsecnidazole$EVFMEvofem Biosciences, Inc.
- Sep 17, 2027321dI-951LETROZOLELETROZOLEYiling Pharmaceutical Ltd
- Sep 17, 2027321dI-950Kisqaliribociclib succinate$NVSNOVARTIS AG
- Sep 18, 2027322dpatentAzelexazelaic acidAlmirall SA
- Sep 22, 2027326dNCEOmlontiomidenepag isopropylOcuvex Therapeutics Inc
- Sep 26, 2027330dpatentAPREPITANTAPREPITANT$HOTHHoth Therapeutics, Inc.
- Sep 26, 2027330dpatentArgatrobanargatrobanMylan Institutional Inc
- Sep 27, 2027331dpatentBetamethasone Dipropionate + Calcipotriene Perrigo(betamethasone dipropionate + calcipotriene)Perrigo New York Inc
- Sep 29, 2027333dNCESODIUM PHENYLBUTYRATESODIUM PHENYLBUTYRATEHorizon Therapeutics USA Inc
- Sep 30, 2027334dNCELytgobifutibatinibTaiho Oncology Inc
- Oct 3, 2027337dpatentTymlosabaloparatideRadius Health Inc
- Oct 3, 2027337dpatentOnpattropatisiran$ALNYALNYLAM PHARMACEUTICALS, INC.
- Oct 4, 2027338dD-194Ameluzaminolevulinic acid hydrochloride$BFRIBiofrontera Inc.
- Oct 4, 2027338dpatentNebivolol Hydrochloridenebivolol hydrochlorideBeximco Pharmaceuticals USA Inc
sourced from FDA Orange Book · approved drugs only · biologics + biosimilars excluded (those live in the Purple Book — coming soon)